How dangerous could reta be worst case scenario

tststs

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I know that reta is still in clinical trials and is not fda approved, but worst case scenario, whats the most harm reta could do to someone if it ends up having an issue.
 
The most serious known risks from clinical trials could include pancreatitis, thyroid tumors (theoretical based on animal studies), and severe GI side effects like vomiting or diarrhea that can lead to dehydration. There’s also some risk of gallbladder issues and low blood sugar, especially if used with other diabetes meds. Like with any new research, we’ll know more about rare or long-term effects once it’s used in larger populations over time.
 
I know that reta is still in clinical trials and is not fda approved, but worst case scenario, whats the most harm reta could do to someone if it ends up having an issue.
EL expanded the number of trials and extended the length of the trials. If there were serious negative indications they would not have done this. It makes sense from their behavior that the side effects are not substantially worse than tirzepatide. It does cost hundreds of millions to do all these trials.

I think the real purpose of extending the trials is that they didn't find a plateau at 80 weeks and they wanted longer data to show just how long you could take it and still lose weight. That, and they want to run up the score against Novo Nordisk. EL is positioning themselves to have Reta be the dominant weight loss medication for years. Even with new GLPs coming out, no one will have the performance and length of data to back it up like they will on Reta.

Just speaking for myself, I am perfectly comfortable taking Reta, so long as the grey market stuff is 3rd party tested.
 
I know I shouldn't have laughed at this
We laugh so we don’t cry. It’s one of those uncomfortable truths about what we are all doing here, even pharma users. There is no free lunch, we just don’t really know what the other shoe dropping is going to look like (to mix metaphors).
 

One participant said: “I go to my visits and they’re like, make sure you eat as much as you can. It’s odd to be in an obesity trial and try not to lose any more weight.”

Experts have long warned about the risks associated with extreme and rapid weight loss. Side effects can include pancreatitis (inflammation of the pancreas), gallstones, loss of muscle mass, and weakened bones.

Dr John Batsis, an associate professor of medicine at the University of North Carolina, noted that some of his patients who used similar weight loss treatments became frail and even suffered fractures.
 
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For all we know any GLP-1 will all kills us exactly 37.4 years after we inject the first dose. Worst case scenario for drugs that have existed less than a human lifespan is a whole lot of question marks.

But the phase 3 trials would have been ended early if they were seeing significant health issues. Instead they keep getting extended so that the total lost weight number can be advertised as being higher.

Most risks seem to be similar to GLP-1s in general, and some additional ones around RHR increase.
 

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