How dangerous could reta be worst case scenario

[tststs]

I know that reta is still in clinical trials and is not fda approved, but worst case scenario, whats the most harm reta could do to someone if it ends up having an issue.

 

[mlke6]

I know that reta is still in clinical trials and is not fda approved, but worst case scenario, whats the most harm reta could do to someone if it ends up having an issue.

Death

 

[Vicki]

Just take prescription medicine. Tirzepatide works very well

 

[kpake]

The most serious known risks from clinical trials could include pancreatitis, thyroid tumors (theoretical based on animal studies), and severe GI side effects like vomiting or diarrhea that can lead to dehydration. There’s also some risk of gallbladder issues and low blood sugar, especially if used with other diabetes meds. Like with any new research, we’ll know more about rare or long-term effects once it’s used in larger populations over time.

 

[exploitedworkerbee]

I’d think freaky cancers are on the table.

 

[Garbo]

I’d think freaky cancers are on the table.

I know I shouldn't have laughed at this

 

[m100568]

I know that reta is still in clinical trials and is not fda approved, but worst case scenario, whats the most harm reta could do to someone if it ends up having an issue.

EL expanded the number of trials and extended the length of the trials. If there were serious negative indications they would not have done this. It makes sense from their behavior that the side effects are not substantially worse than tirzepatide. It does cost hundreds of millions to do all these trials.

I think the real purpose of extending the trials is that they didn't find a plateau at 80 weeks and they wanted longer data to show just how long you could take it and still lose weight. That, and they want to run up the score against Novo Nordisk. EL is positioning themselves to have Reta be the dominant weight loss medication for years. Even with new GLPs coming out, no one will have the performance and length of data to back it up like they will on Reta.

Just speaking for myself, I am perfectly comfortable taking Reta, so long as the grey market stuff is 3rd party tested.

 

[exploitedworkerbee]

I know I shouldn't have laughed at this

We laugh so we don’t cry. It’s one of those uncomfortable truths about what we are all doing here, even pharma users. There is no free lunch, we just don’t really know what the other shoe dropping is going to look like (to mix metaphors).

 

[Calm Logic]

Retatrutide melts fat fast but at a cost warn experts

A new weight loss injection called retatrutide has shown remarkable results in…

www.diabetes.co.uk

One participant said: “I go to my visits and they’re like, make sure you eat as much as you can. It’s odd to be in an obesity trial and try not to lose any more weight.”

Experts have long warned about the risks associated with extreme and rapid weight loss. Side effects can include pancreatitis (inflammation of the pancreas), gallstones, loss of muscle mass, and weakened bones.

Dr John Batsis, an associate professor of medicine at the University of North Carolina, noted that some of his patients who used similar weight loss treatments became frail and even suffered fractures.

 

[hexagonal]

For all we know any GLP-1 will all kills us exactly 37.4 years after we inject the first dose. Worst case scenario for drugs that have existed less than a human lifespan is a whole lot of question marks.

But the phase 3 trials would have been ended early if they were seeing significant health issues. Instead they keep getting extended so that the total lost weight number can be advertised as being higher.

Most risks seem to be similar to GLP-1s in general, and some additional ones around RHR increase.

 

[rkl123]

The thyroid cancer thing is a theoretical from mice. It has NOT been seen in any human data at all. It is a disclaimer because it was faster to put the disclaimer and be approved than do clinical trials trying to somehow prove it doesn’t cause thyroid cancer. In big data EMR studies, we see lower cancer rates in GLP users.

Moreover, in March they published mice data. They found sema has modest anticancer effects in the mice. Reta had insane anti cancer effects in the mice. It remains to be seen if this holds true for humans or not, but if it did, reta would be used in some cohorts of cancer patients.

 

[Know1]

We laugh so we don’t cry. It’s one of those uncomfortable truths about what we are all doing here, even pharma users. There is no free lunch, we just don’t really know what the other shoe dropping is going to look like (to mix metaphors).

I would prefer to believe if not free lunch for some of us on these newer GLP-1 medications, there is at least a free dessert. I've only recently begun with sema, but given that I was approaching death at my starting weight, my results so far feel like a new lease on life. My problem seems to have a genetic component stretching through generations in both directions. Perhaps my "disease" evolved in some earlier age for surviving famines or slavery, but in the current environment it is maladaptive. Although my experience is limited, I'm hoping I've finally found what my body has been lacking all of these years. So yeah, definitely not free, and there are side effects of varying severity, but for most we're still better off than we were. While we still live, it doesn't have to be a zero-sum game.

Apologies if I strayed off- topic.

 

[exploitedworkerbee]

I would prefer to believe if not free lunch for some of us on these newer GLP-1 medications, there is at least a free dessert. I've only recently begun with sema, but given that I was approaching death at my starting weight, my results so far feel like a new lease on life. My problem seems to have a genetic component stretching through generations in both directions. Perhaps my "disease" evolved in some earlier age for surviving famines or slavery, but in the current environment it is maladaptive. Although my experience is limited, I'm hoping I've finally found what my body has been lacking all of these years. So yeah, definitely not free, and there are side effects of varying severity, but for most we're still better off than we were. While we still live, it doesn't have to be a zero-sum game.

Apologies if I strayed off- topic.

Sure, totally agree. There are lots of meds that are a net positive so we take them even with known side effects. I’m just saying that glp1s are pretty new and SO heavily tilted in the positive direction that it’s hard to accept that some presently unknown side effects won’t come along to even things out a bit more. Perhaps that won’t happen and these are indeed a rare class of miracle drug that is all good, almost no bad. That’s what I’ll be hoping for because i take em.

 

[Skidude]

Sure, totally agree. There are lots of meds that are a net positive so we take them even with known side effects. I’m just saying that glp1s are pretty new and SO heavily tilted in the positive direction that it’s hard to accept that some presently unknown side effects won’t come along to even things out a bit more. Perhaps that won’t happen and these are indeed a rare class of miracle drug that is all good, almost no bad. That’s what I’ll be hoping for because i take em.

The other side of this argument would be how taking a "perfect" drug would have potential negative effects.
The act of injection does pose some dangers as does the result of reduced nutrition.
In the event of either of those things occurring it could result in many negative effects impacting health and longevity.

Aside from nutrition and sterility issues, there is the slippery slope of a new addiction that has us acquiring questionable powders from the far east and injecting with minimal understanding of interaction, quality, or overall impact on our health.

Dangerous hobbies include: SCUBA, Skydiving, Motorcycles, and PEPS... to name a few

 

[Calm Logic]

Regarding heart rate concerns:

Eh, smaller doses generally = smaller side effects

However recent info from the trials reveal that there seems to be a coorelation between your current blood pressure and whether or not you will get a rise in heart rate from reta

Low blood pressure = more likely to get heart rate increase

In any case, some like @Ted R have used survo with tirz instead:

One size definitely doesn't fit all in this arena.

Reta spiked my rate to ~125 after only 2 hrs. after my first dose, and it took 4 weeks after stopping to return to my normal 68-70.

Started Tirz then at 2.5, have advanced to 7.5 every 5 days and and Surv2 3 days later and still normal HR.

 

[dogmom]

Honestly no one really knows. It is still being studied.

 

[Humphries365]

I wake up with really bad heartburn 🙄

 

[keangkong]

Death

Agreed. I take reta too. However, I will not advise anyone that the medicine won't cause death because without the clinical trials having been completed, I can't give a less severe worst case outcome.

 

[Iamnew2this]

Agreed. I take reta too. However, I will not advise anyone that the medicine won't cause death because without the clinical trials having been completed, I can't give a less severe worst case outcome.

I would have loved to have tried reta. However, in my case, I have heart issues. Death IS the very worst thing that can likely happen and this is why I, myself, won't touch it.

 

[mousey]

I would have loved to have tried reta. However, in my case, I have heart issues. Death IS the very worst thing that can likely happen and this is why I, myself, won't touch it.

I have heart issues too (41% EF) so I've put off trying reta till the studies are complete. I'm not sure if they are including people with heart problems in the studies to see if it's safe or not? I've read some say after a few months the heart palpitations go away.

Usually I say glp-s1s are probably safe because liraglutide and exenatide have been out for about 15 years already and they had years of studies before going to market like reta and the other have. Semaglutide and I believe tirz are approved for heart disease, preventing strokes and heart attacks. Will reta be the lone one out and the one that causes heart attacks and kills us?

 

[Iamnew2this]

I have heart issues too (41% EF) so I've put off trying reta till the studies are complete. I'm not sure if they are including people with heart problems in the studies to see if it's safe or not? I've read some say after a few months the heart palpitations go away.

Usually I say glp-s1s are probably safe because liraglutide and exenatide have been out for about 15 years already and they had years of studies before going to market like reta and the other have. Semaglutide and I believe tirz are approved for heart disease, preventing strokes and heart attacks. Will reta be the lone one out and the one that causes heart attacks and kills us?

I will never try it. I have sinus node dysfunction amongst other issues that cause palpatations and angina. I also have a pacemaker. Although, I would have loved to have tried reta, I will skip it altogether. I have tried sema and that was fine. Tirz has worked wonders for me. Taking tirz/sema and a lifestyle change has been key. Both of my doctors are on board. I feel if it's not broken, don't fix it. I will pass taking reta. I don't know your particular situation. However, speaking in general, losing weight might help the heart work more efficiently. My weight loss has helped me. I lost 80+ lbs in less than a year. I only walk for exercise. Right now the cardiologist put a hold on my metoprolol. So far, so good 🤞. I wish you the best of luck! Cheers to feeling better!❤️

 

[Calm Logic]

I wake up with really bad heartburn 🙄

India sells generic Voquezna.