In Novo’s Own Words: Degradation of Amylin Analogs Such as Cagrilintide (and How to Test For It)

[scarywood75]

You seem to have a weird fibril fetish and are well known for it in the community. I’m pretty sure others have already tried to talk you down so I won’t waste my breath. I will refer you to my previous comment and cited article.

Who are you to judge people's fetishes, I'm sure you have some too

 

[nurseratchit]

Who are you to judge people's fetishes, I'm sure you have some too

I don’t care what anyone else’s fetishes are as long as they don’t try to force it on anyone else.

 

[DevynL90]

You seem to have a weird fibril fetish and are well known for it in the community. I’m pretty sure others have already tried to talk you down so I won’t waste my breath. I will refer you to my previous comment and cited article.

i don't understand this strong reaction some folks are having to the mere suggestion that a drug that still hasn't made it out of clinical trials *gasp* might not actually be totally safe for humans?

ignore or say why it's wrong. why throw out random insults around fetishes and claims that he's someone (megalith) when he so clearly isn't?

 

[penewbie]

This forum fucking sucks.

And the worst thing of all it's the best GLP1 forum there is.

Fuck.

 

[scarywood75]

I don’t care what anyone else’s fetishes are as long as they don’t try to force it on anyone else.

Oh yeah I'm sure everyone here really feel forced

 

[scarywood75]

This forum fucking sucks.

And the worst thing of all it's the best GLP1 forum there is.

Fuck.

Hehe, take good informations and just discard the rest, I don't bother sharing anything anymore like a ton of good members here

You gotta think like the rest of them, play along

 

[scarywood75]

It's like a sect almost

 

[secretweapon]

For the chemistry majors here’s research article about amylin and fibrils. For the TL;DR, yes fibrils were a concern which is why modifications have been made to cagri to suppress fibril development. You can scroll to the summary at the end if chemistry isn’t your thing.

https://doi.org/10.1021/acs.jmedchem.1c00565

I already linked to this article in my original post and heavily quoted from it, as well as several other sister reports from Novo. Clearly you never read my post to begin with if you think your post somehow counters it.

 

[scarywood75]

I already linked to this article in my original post and heavily quoted from it, as well as several other sister reports from Novo. Clearly you never read my post to begin with if you think your post somehow counters it.

I admire your persistence sir/mam

 

[nurseratchit]

i don't understand this strong reaction some folks are having to the mere suggestion that a drug that still hasn't made it out of clinical trials *gasp* might not actually be totally safe for humans?

ignore or say why it's wrong. why throw out random insults around fetishes and claims that he's someone (megalith) when he so clearly isn't?

If you keep reading you can see that I did, with a cited article. I think qualligator.com will be much more receptive to this post.

 

[DevynL90]

If you keep reading you can see that I did, with a cited article. I think qualligator.com will be much more receptive to this post.

qualligator is gonna absolutely HATE this guy lmao idk what you're talking about. and as secret mentioned above, your link was already cited in his opening thesis. it makes it sound like you didn't even read it before rejecting it outright. that's very gator-like imo.

 

[scarywood75]

If you keep reading you can see that I did, with a cited article. I think qualligator.com will be much more receptive to this post.

You don't need to follow safety advices, nobody is forcing you to, hopefully you'll sleep well anyway

 

[secretweapon]

If you keep reading you can see that I did, with a cited article. I think qualligator.com will be much more receptive to this post.

You cited the same article that I already cited first. It's literally the first link on my list of citations.

Except it proves my point, not yours.

 

[brentm]

qualligator is gonna absolutely HATE this guy lmao idk what you're talking about. and as secret mentioned above, your link was already cited in his opening thesis. it makes it sound like you didn't even read it before rejecting it outright. that's very gator-like imo.

qualligator forum sucks anyways..

dumb name.
geocities vibe.
guy that runs it sucks too.

 

[nurseratchit]

I already linked to this article in my original post and heavily quoted from it, as well as several other sister reports from Novo. Clearly you never read my post to begin with if you think your post somehow counters it.

Then I don’t think you understood the article. What exactly are your concerns? Even if your cagri did have fibrils, they will not cross the blood-brain barrier or enter into your bloodstream. Maybe you’d get an ISR which plenty of people already get with tirz. No human trials to date have shown any amyloid fibrillation formation.

 

[nurseratchit]

You cited the same article that I already cited first. It's literally the first link on my list of citations.

Except it proves my point, not yours.

You’re right I diid not closely read his lengthy post but I have seen this around elsewhere. The chemistry article does not support his fibril fears IMO.

 

[scarywood75]

Then I don’t think you understood the article. What exactly are your concerns? Even if your cagri did have fibrils, they will not cross the blood-brain barrier or enter into your bloodstream. Maybe you’d get an ISR which plenty of people already get with tirz. No human trials to date have shown any amyloid fibrillation formation.

You're missing the point he's making, try again

 

[brentm]

Then I don’t think you understood the article. What exactly are your concerns? Even if your cagri did have fibrils, they will not cross the blood-brain barrier or enter into your bloodstream. Maybe you’d get an ISR which plenty of people already get with tirz. No human trials to date have shown any amyloid fibrillation formation.

You should read his post...

“Some of these toxic oligomeric species are associated with beta-cell death and the progression of type 2 diabetes (16−18)”​

Here, they cite research showing that not fibrils, but toxic oligomers are what cause the death of the insulin-producing beta cells in the pancreas. This is from the first study cited:

So while brain is obv concern... He's saying it's possibly hard on your pancreas.

 

[secretweapon]

You’re right I diid not closely read his lengthy post but I have seen this around elsewhere. The chemistry article does not support his fibril fears IMO.

Once again, I'm not concerned in the slightest about fibrils.

 

[secretweapon]

Then I don’t think you understood the article. What exactly are your concerns? Even if your cagri did have fibrils, they will not cross the blood-brain barrier or enter into your bloodstream. Maybe you’d get an ISR which plenty of people already get with tirz. No human trials to date have shown any amyloid fibrillation formation.

You are very confused...