scarywood75
Scarlett Johansson
You don't need to follow safety advices, nobody is forcing you to, hopefully you'll sleep well anyway
In Novo’s Own Words: Degradation of Amylin Analogs Such as Cagrilintide (and How to Test For It)
- Thread starter secretweapon
- Start date
secretweapon
New_Member
You cited the same article that I already cited first. It's literally the first link on my list of citations.
Except it proves my point, not yours.
nurseratchit
Research Enthusiast
Then I don’t think you understood the article. What exactly are your concerns? Even if your cagri did have fibrils, they will not cross the blood-brain barrier or enter into your bloodstream. Maybe you’d get an ISR which plenty of people already get with tirz. No human trials to date have shown any amyloid fibrillation formation.I already linked to this article in my original post and heavily quoted from it, as well as several other sister reports from Novo. Clearly you never read my post to begin with if you think your post somehow counters it.
nurseratchit
Research Enthusiast
You’re right I diid not closely read his lengthy post but I have seen this around elsewhere. The chemistry article does not support his fibril fears IMO.You cited the same article that I already cited first. It's literally the first link on my list of citations.
Except it proves my point, not yours.
scarywood75
Scarlett Johansson
You're missing the point he's making, try again
You should read his post...
So while brain is obv concern... He's saying it's possibly hard on your pancreas.
secretweapon
New_Member
Once again, I'm not concerned in the slightest about fibrils.
secretweapon
New_Member
You are very confused...
scarywood75
Scarlett Johansson
You're fighting over something that was not even a concern raised by OP, maybe you should've read it
nurseratchit
Research Enthusiast
oh yay...we have a moderator now! Our cherub of justice could use the help!
nurseratchit
Research Enthusiast
You didn't answer my question. Not that I expected you to.
secretweapon
New_Member
My concerns are in my original post. Read that, and your question is already answered.
We went over this in the other thread - that is not what this section says. The table with the ThT assay results specifically shows they were able to form fibrils at 7.5
I don't know if fibrils (or oligomers) are of concern but y'all need to stop sharing this link acting like it says cagrilintide does not form fibrils at 7.5, because the paper explicitly says that it does.
Go to Table 5 and look at analogue 23 - that is cagrilintide - and look at the results for the 7.5 pH. It explicitly fails the metrics they set for the assay to be considered a success.
raw_oyster_eater
lemon bottle brewer
weird thing. the first few times i used cagri i got little shooting pains in my head. i haven't used that much of it and this gives me pause.
ok, you guys can have a field day with that.
ok, you guys can have a field day with that.
EDIT: Nevermind. I used chatgpt to help sort out this study... Here's what it said...
While the results indicate that Compound 23 did not entirely avoid fibrillation at pH 7.5, it demonstrated delayed onset and moderate recovery, making it less prone to fibrillation than many other analogues. However, this performance still falls short of the study's ideal metrics for fibrillation resistance.
Why Was This Tolerated?
The study's authors prioritized stability under the intended formulation conditions (pH 4.0), where Compound 23 performed well:- At pH 4.0, Compound 23 exhibited a long lag time (45 hours) and high recovery (96%), indicating robust stability in the acidic conditions planned for its use.
- The lower pH mitigates fibrillation risk during storage and administration, making it clinically acceptable despite its suboptimal performance at pH 7.5.
Conclusion:
Yes, Compound 23 formed fibrils at pH 7.5, as evidenced by the lag time and reduced peptide recovery in the assay. However, its overall performance across conditions and suitability for acidic formulations justified its selection for clinical development.
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All but convinced this is megaliths original discord username and megalith was his alt for peptide purposes. Even went back and compared grammar and writing styles.
Last night, I applauded him for his compilation of research and conclusions, but yet he just couldn't stop responding over if we believed the peptide community was "turning" toward accepting the conclusions.
Both he and megalith (if they are even two different people) care more about being seen as the smartest person in the room and attacking others in a derogatory manner than they do about letting the science speak for itself.
No one will ever take either of them seriously because of their approach. Put your ego(s) aside and try to have some discourse. Both of you are way too in your feelings on the topic and it hampers credibility.
Even if I said the conversation didn't need to continue, as we were aligned on the science, but not aligned on the "community" changing their opinion, he still simply couldn't let it go and reiterated a point that had nothing do with what we weren't agreeing on.
The loudest person in the room is never the smartest. If you aren't megalith, maybe learn from his mistakes and try a different approach.
Last night, I applauded him for his compilation of research and conclusions, but yet he just couldn't stop responding over if we believed the peptide community was "turning" toward accepting the conclusions.
Both he and megalith (if they are even two different people) care more about being seen as the smartest person in the room and attacking others in a derogatory manner than they do about letting the science speak for itself.
No one will ever take either of them seriously because of their approach. Put your ego(s) aside and try to have some discourse. Both of you are way too in your feelings on the topic and it hampers credibility.
Even if I said the conversation didn't need to continue, as we were aligned on the science, but not aligned on the "community" changing their opinion, he still simply couldn't let it go and reiterated a point that had nothing do with what we weren't agreeing on.
The loudest person in the room is never the smartest. If you aren't megalith, maybe learn from his mistakes and try a different approach.
secretweapon
New_Member
Here's exactly what happened.
I said the tide has been turning of late about this cagrilintide topic.
You denied it.
I suggested maybe you're just not up to date, and I pointed to evidence: multiple people within the chat including the server owner who said they had finally been persuaded by my recent write-up (the same one I posted here).
You mocked my response with a laugh-react (
) and then once again denied that the tide was turning, citing the cagrilintide promos that had been selling out as evidence.My response:
Then you got defensive and accused me of being "condescending" because I said "you seem to be conflating." But you did conflate them, and as I responded:
Then you went back and heavily edited ALL of your previous messages, making them sound more reasonable.
And now, here you are dragging this petty grievance onto another platform, acting like a victim when you started with the mocking and couldn't handle a little "condescension" in return.
The tide *is* turning and you loudly denying it across multiple platforms ain't gonna change that.
And now you say:
Except you already take me seriously. You praised my write-up repeatedly and described it as "persuasive."
That's one more person publicly aligning themselves with Novo Nordisk, demonstrating the continued turning of the tide.
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secretweapon
New_Member
Let me get this straight.
You reply several times to my post, never addressing any of the actual science in it, but instead repeatedly launching ad hominems, personal insults, conspiracy theories about my "true" identity, and lies of omission to misrepresent me.
But I'm the "giant asshole" here because my first post was a rigorously-researched report with extensive citations about a contentious topic that's being vigorously-debated across multiple platforms including this one.
Got it.
