scarywood75
Research Enthusiast
You're fighting over something that was not even a concern raised by OP, maybe you should've read it
In Novo’s Own Words: Degradation of Amylin Analogs Such as Cagrilintide (and How to Test For It)
- Thread starter secretweapon
- Start date
nurseratchit
Research Enthusiast
Right…the place where oyster has his own reef?!
You’re right…I did not closely read this whole screed tonight but have seen him going to town with it elsewhere and it is tiresome. And a bit extra for ones first post on his first day in the forum.
oyster and the vast majority of them are going to be absolutely nauseas at the mere suggestion that vendors don't always have their best interests in mind when it comes to safety and are actually just out to make as much money as quickly as they can. idk how this guy throwing a wrench into that delusion of theirs is gonna make him a fan favorite over there anytime soon.Right…the place where oyster has his own reef?!
all i know is i want a front row seat for if/when he ever does make the pilgrimage. he's a florida guy too! he knows how to rassle with dem gators in the mud.
nurseratchit
Research Enthusiast
oh yay...we have a moderator now! Our cherub of justice could use the help!
nurseratchit
Research Enthusiast
You didn't answer my question. Not that I expected you to.
secretweapon
New_Member
My concerns are in my original post. Read that, and your question is already answered.
We went over this in the other thread - that is not what this section says. The table with the ThT assay results specifically shows they were able to form fibrils at 7.5
I don't know if fibrils (or oligomers) are of concern but y'all need to stop sharing this link acting like it says cagrilintide does not form fibrils at 7.5, because the paper explicitly says that it does.
Go to Table 5 and look at analogue 23 - that is cagrilintide - and look at the results for the 7.5 pH. It explicitly fails the metrics they set for the assay to be considered a success.
raw_oyster_eater
New_Member
weird thing. the first few times i used cagri i got little shooting pains in my head. i haven't used that much of it and this gives me pause.
ok, you guys can have a field day with that.
ok, you guys can have a field day with that.
I can’t speak for everyone, but personally I have no problem with the idea that cagri could have some requirement to be reconstituted at a certain ph for efficacy or safety or both. It’s something that should be discussed.
However, the origin of it (as I gather you’re well aware) was based on a sloppy mess of megalith’s chatgpt theories that didn’t pass muster, and since then the topic has been a magnet for “I am very smart, don’t my farts smell nice?” blowhards. My pushback on OP was not about the content of his community college analytical commentary of some research papers, it was the joining a forum and being a giant asshole in the first post. It was particularly triggering because how on-brand it was for these cagri ph guys.
Mark my words: ph buffered cagri coming from baba using some fun new filler in the coming months. All of a sudden they will all be very interested in the topic, and supportive of the theory.
EDIT: Nevermind. I used chatgpt to help sort out this study... Here's what it said...
While the results indicate that Compound 23 did not entirely avoid fibrillation at pH 7.5, it demonstrated delayed onset and moderate recovery, making it less prone to fibrillation than many other analogues. However, this performance still falls short of the study's ideal metrics for fibrillation resistance.
Why Was This Tolerated?
The study's authors prioritized stability under the intended formulation conditions (pH 4.0), where Compound 23 performed well:- At pH 4.0, Compound 23 exhibited a long lag time (45 hours) and high recovery (96%), indicating robust stability in the acidic conditions planned for its use.
- The lower pH mitigates fibrillation risk during storage and administration, making it clinically acceptable despite its suboptimal performance at pH 7.5.
Conclusion:
Yes, Compound 23 formed fibrils at pH 7.5, as evidenced by the lag time and reduced peptide recovery in the assay. However, its overall performance across conditions and suitability for acidic formulations justified its selection for clinical development.
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All but convinced this is megaliths original discord username and megalith was his alt for peptide purposes. Even went back and compared grammar and writing styles.
Last night, I applauded him for his compilation of research and conclusions, but yet he just couldn't stop responding over if we believed the peptide community was "turning" toward accepting the conclusions.
Both he and megalith (if they are even two different people) care more about being seen as the smartest person in the room and attacking others in a derogatory manner than they do about letting the science speak for itself.
No one will ever take either of them seriously because of their approach. Put your ego(s) aside and try to have some discourse. Both of you are way too in your feelings on the topic and it hampers credibility.
Even if I said the conversation didn't need to continue, as we were aligned on the science, but not aligned on the "community" changing their opinion, he still simply couldn't let it go and reiterated a point that had nothing do with what we weren't agreeing on.
The loudest person in the room is never the smartest. If you aren't megalith, maybe learn from his mistakes and try a different approach.
Last night, I applauded him for his compilation of research and conclusions, but yet he just couldn't stop responding over if we believed the peptide community was "turning" toward accepting the conclusions.
Both he and megalith (if they are even two different people) care more about being seen as the smartest person in the room and attacking others in a derogatory manner than they do about letting the science speak for itself.
No one will ever take either of them seriously because of their approach. Put your ego(s) aside and try to have some discourse. Both of you are way too in your feelings on the topic and it hampers credibility.
Even if I said the conversation didn't need to continue, as we were aligned on the science, but not aligned on the "community" changing their opinion, he still simply couldn't let it go and reiterated a point that had nothing do with what we weren't agreeing on.
The loudest person in the room is never the smartest. If you aren't megalith, maybe learn from his mistakes and try a different approach.
secretweapon
New_Member
Here's exactly what happened.
I said the tide has been turning of late about this cagrilintide topic.
You denied it.
I suggested maybe you're just not up to date, and I pointed to evidence: multiple people within the chat including the server owner who said they had finally been persuaded by my recent write-up (the same one I posted here).
You mocked my response with a laugh-react (
) and then once again denied that the tide was turning, citing the cagrilintide promos that had been selling out as evidence.My response:
Then you got defensive and accused me of being "condescending" because I said "you seem to be conflating." But you did conflate them, and as I responded:
Then you went back and heavily edited ALL of your previous messages, making them sound more reasonable.
And now, here you are dragging this petty grievance onto another platform, acting like a victim when you started with the mocking and couldn't handle a little "condescension" in return.
The tide *is* turning and you loudly denying it across multiple platforms ain't gonna change that.
And now you say:
Except you already take me seriously. You praised my write-up repeatedly and described it as "persuasive."
That's one more person publicly aligning themselves with Novo Nordisk, demonstrating the continued turning of the tide.
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secretweapon
New_Member
Let me get this straight.
You reply several times to my post, never addressing any of the actual science in it, but instead repeatedly launching ad hominems, personal insults, conspiracy theories about my "true" identity, and lies of omission to misrepresent me.
But I'm the "giant asshole" here because my first post was a rigorously-researched report with extensive citations about a contentious topic that's being vigorously-debated across multiple platforms including this one.
Got it.
Here he goes again. Even after I agreed with him again in the post on it being persuasive. But I had reached the conclusion before your write up. So please don't give yourself to much of a pat on the back.Here's exactly what happened.
I said the tide has been turning of late about this cagrilintide topic.
You denied it.
I said maybe you're just not up to date, and I pointed to evidence: multiple people within the chat including the server owner who said they had finally been persuaded by my recent write-up (the same one I posted here).
You mocked my response with a laugh-react (
My response:
Then you got defensive and accused me of being "condescending" because I said "you seem to be conflating." But you did conflate them, and as I responded:
And now, here you are dragging this petty grievance onto another platform, acting like a victim when you started with the mocking and couldn't handle a little "condescension" in return.
The tide *is* turning and you loudly denying it across multiple platforms ain't gonna change that.
And now you say:
Except you already take me seriously. You praised my write-up repeatedly and described it as "persuasive."
That's one more person publicly aligning themselves with Novo Nordisk, demonstrating the continued turning of the tide.
I told you and stated above I don't think anything is turning in the community. And your diatribe is just even more reason why it won't turn. For fucks sake. 3 people messaging you and you typing up a summary isnt enough to constitute turning in my opinion.
You and megalith both have the emotional intelligence of a 5 year old. Yall care more about being seen as credible than you do just being a contributor. You're doing more harm than good.
Keep being so loud. Or change your approach. Either way, doesnt matter. You dk you, booboo
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secretweapon
New_Member
You conveniently omitted the part about vendors now offering pH-buffered cagrilintide, in response to demand from customers.
You were the first to make a market argument (that cagri promos are selling out).
I responded with a market argument.
Both show demand, except mine demonstrates a recent change in market behavior. You can continue to ignore this fact all you want.
Which platform are you going to air your petty grievances on next?
Maybe you are just butthurt about the Hurricanes losing after blowing that early 21-0 lead?
secretweapon
New_Member
All it takes is a laughing emoji to get both he and megalith in their feelings
I am "in my feelings" because I said the following to you?
After which you cried about me being condescending? Textbook case of projection.
You were so butthurt that you had to go whine about me being "condescending" on another platform.
