scarywood75
Scarlett Johansson
You guys and girls had a rough week, it's time to let it all out 😎
In Novo’s Own Words: Degradation of Amylin Analogs Such as Cagrilintide (and How to Test For It)
- Thread starter secretweapon
- Start date
nurseratchit
GLP-1 Specialist
You seem to have a weird fibril fetish and are well known for it in the community. I’m pretty sure others have already tried to talk you down so I won’t waste my breath. I will refer you to my previous comment and cited article.
scarywood75
Scarlett Johansson
Who are you to judge people's fetishes, I'm sure you have some too 😶🌫️
nurseratchit
GLP-1 Specialist
I don’t care what anyone else’s fetishes are as long as they don’t try to force it on anyone else.
penewbie
GLP-1 Specialist
This forum fucking sucks.
And the worst thing of all it's the best GLP1 forum there is.
Fuck.
And the worst thing of all it's the best GLP1 forum there is.
Fuck.
scarywood75
Scarlett Johansson
Oh yeah I'm sure everyone here really feel forced 🤣
scarywood75
Scarlett Johansson
Hehe, take good informations and just discard the rest, I don't bother sharing anything anymore like a ton of good members here
You gotta think like the rest of them, play along
scarywood75
Scarlett Johansson
It's like a sect almost 🫠
secretweapon
New Member
I already linked to this article in my original post and heavily quoted from it, as well as several other sister reports from Novo. Clearly you never read my post to begin with if you think your post somehow counters it. 🙃
scarywood75
Scarlett Johansson
I admire your persistence sir/mam
scarywood75
Scarlett Johansson
You don't need to follow safety advices, nobody is forcing you to, hopefully you'll sleep well anyway 🙏
secretweapon
New Member
You cited the same article that I already cited first. It's literally the first link on my list of citations.
Except it proves my point, not yours. 🙃
nurseratchit
GLP-1 Specialist
Then I don’t think you understood the article. What exactly are your concerns? Even if your cagri did have fibrils, they will not cross the blood-brain barrier or enter into your bloodstream. Maybe you’d get an ISR which plenty of people already get with tirz. No human trials to date have shown any amyloid fibrillation formation.
nurseratchit
GLP-1 Specialist
You’re right I diid not closely read his lengthy post but I have seen this around elsewhere. The chemistry article does not support his fibril fears IMO.
scarywood75
Scarlett Johansson
You're missing the point he's making, try again
You should read his post...
So while brain is obv concern... He's saying it's possibly hard on your pancreas.
secretweapon
New Member
Once again, I'm not concerned in the slightest about fibrils.
secretweapon
New Member
You are very confused...
scarywood75
Scarlett Johansson
You're fighting over something that was not even a concern raised by OP, maybe you should've read it
nurseratchit
GLP-1 Specialist
oh yay...we have a moderator now! Our cherub of justice could use the help!
nurseratchit
GLP-1 Specialist
You didn't answer my question. Not that I expected you to.
secretweapon
New Member
My concerns are in my original post. Read that, and your question is already answered. 🙄
We went over this in the other thread - that is not what this section says. The table with the ThT assay results specifically shows they were able to form fibrils at 7.5
I don't know if fibrils (or oligomers) are of concern but y'all need to stop sharing this link acting like it says cagrilintide does not form fibrils at 7.5, because the paper explicitly says that it does.
Go to Table 5 and look at analogue 23 - that is cagrilintide - and look at the results for the 7.5 pH. It explicitly fails the metrics they set for the assay to be considered a success.
raw_oyster_eater
lemon bottle brewer
weird thing. the first few times i used cagri i got little shooting pains in my head. i haven't used that much of it and this gives me pause.
ok, you guys can have a field day with that.
ok, you guys can have a field day with that.
EDIT: Nevermind. I used chatgpt to help sort out this study... Here's what it said...
While the results indicate that Compound 23 did not entirely avoid fibrillation at pH 7.5, it demonstrated delayed onset and moderate recovery, making it less prone to fibrillation than many other analogues. However, this performance still falls short of the study's ideal metrics for fibrillation resistance.
Why Was This Tolerated?
The study's authors prioritized stability under the intended formulation conditions (pH 4.0), where Compound 23 performed well:- At pH 4.0, Compound 23 exhibited a long lag time (45 hours) and high recovery (96%), indicating robust stability in the acidic conditions planned for its use.
- The lower pH mitigates fibrillation risk during storage and administration, making it clinically acceptable despite its suboptimal performance at pH 7.5.
Conclusion:
Yes, Compound 23 formed fibrils at pH 7.5, as evidenced by the lag time and reduced peptide recovery in the assay. However, its overall performance across conditions and suitability for acidic formulations justified its selection for clinical development.
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All but convinced this is megaliths original discord username and megalith was his alt for peptide purposes. Even went back and compared grammar and writing styles.
Last night, I applauded him for his compilation of research and conclusions, but yet he just couldn't stop responding over if we believed the peptide community was "turning" toward accepting the conclusions.
Both he and megalith (if they are even two different people) care more about being seen as the smartest person in the room and attacking others in a derogatory manner than they do about letting the science speak for itself.
No one will ever take either of them seriously because of their approach. Put your ego(s) aside and try to have some discourse. Both of you are way too in your feelings on the topic and it hampers credibility.
Even if I said the conversation didn't need to continue, as we were aligned on the science, but not aligned on the "community" changing their opinion, he still simply couldn't let it go and reiterated a point that had nothing do with what we weren't agreeing on.
The loudest person in the room is never the smartest. If you aren't megalith, maybe learn from his mistakes and try a different approach.
Last night, I applauded him for his compilation of research and conclusions, but yet he just couldn't stop responding over if we believed the peptide community was "turning" toward accepting the conclusions.
Both he and megalith (if they are even two different people) care more about being seen as the smartest person in the room and attacking others in a derogatory manner than they do about letting the science speak for itself.
No one will ever take either of them seriously because of their approach. Put your ego(s) aside and try to have some discourse. Both of you are way too in your feelings on the topic and it hampers credibility.
Even if I said the conversation didn't need to continue, as we were aligned on the science, but not aligned on the "community" changing their opinion, he still simply couldn't let it go and reiterated a point that had nothing do with what we weren't agreeing on.
The loudest person in the room is never the smartest. If you aren't megalith, maybe learn from his mistakes and try a different approach.
secretweapon
New Member
Here's exactly what happened.
I said the tide has been turning of late about this cagrilintide topic.
You denied it.
I suggested maybe you're just not up to date, and I pointed to evidence: multiple people within the chat including the server owner who said they had finally been persuaded by my recent write-up (the same one I posted here).
You mocked my response with a laugh-react (🤣) and then once again denied that the tide was turning, citing the cagrilintide promos that had been selling out as evidence.
My response:
Then you got defensive and accused me of being "condescending" because I said "you seem to be conflating." But you did conflate them, and as I responded:
Then you went back and heavily edited ALL of your previous messages, making them sound more reasonable.
And now, here you are dragging this petty grievance onto another platform, acting like a victim when you started with the mocking and couldn't handle a little "condescension" in return.
The tide *is* turning and you loudly denying it across multiple platforms ain't gonna change that.
And now you say:
Except you already take me seriously. You praised my write-up repeatedly and described it as "persuasive."
That's one more person publicly aligning themselves with Novo Nordisk, demonstrating the continued turning of the tide. 🌊
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secretweapon
New Member
Let me get this straight.
You reply several times to my post, never addressing any of the actual science in it, but instead repeatedly launching ad hominems, personal insults, conspiracy theories about my "true" identity, and lies of omission to misrepresent me.
But I'm the "giant asshole" here because my first post was a rigorously-researched report with extensive citations about a contentious topic that's being vigorously-debated across multiple platforms including this one.
Got it.
Here he goes again. Even after I agreed with him again in the post on it being persuasive. But I had reached the conclusion before your write up. So please don't give yourself to much of a pat on the back.
I told you and stated above I don't think anything is turning in the community. And your diatribe is just even more reason why it won't turn. For fucks sake. 3 people messaging you and you typing up a summary isnt enough to constitute turning in my opinion.
You and megalith both have the emotional intelligence of a 5 year old. Yall care more about being seen as credible than you do just being a contributor. You're doing more harm than good.
Keep being so loud. Or change your approach. Either way, doesnt matter. You dk you, booboo
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secretweapon
New Member
You conveniently omitted the part about vendors now offering pH-buffered cagrilintide, in response to demand from customers.
You were the first to make a market argument (that cagri promos are selling out).
I responded with a market argument.
Both show demand, except mine demonstrates a recent change in market behavior. You can continue to ignore this fact all you want.
Which platform are you going to air your petty grievances on next?
Maybe you are just butthurt about the Hurricanes losing after blowing that early 21-0 lead?
secretweapon
New Member
I am "in my feelings" because I said the following to you?
After which you cried about me being condescending? Textbook case of projection.
You were so butthurt that you had to go whine about me being "condescending" on another platform. 🤣
Never did i cry about anything. The whole comment on condescending with "ey" at the end of it was to point out how similar you and megalith are. And why I think you're the same person. You can't see that. Haha. Someone can go on the Swiss and see the interaction. You will continue to respond even when the conversation doesnt need to continue. You can't walk away. Too much emotion
Again, the emotional intelligence of a 5 year old. Stick with the science, your interactions with people are lacking and hurts your credibility
peptideusername
Moderator
Good lord this is painful.
@secretweapon is obviously just here to argue in a combative fashion, it is what he does on other platforms as well. I'll permit it in this thread only. Have at it, don't spread to other threads.
secretweapon
New Member
No, I'm here to talk science. Are you?
secretweapon
New Member
Do you lie about people on other platforms too or just this one?
In response to @nccane on that other platform, someone had this to say:
That's how I conduct myself on other platforms. But when people completely ignore the science and just talk shit like you've done? Don't play innocent and pretend that you didn't provoke it when it comes back to you.
secretweapon
New Member
DMs from two different people I've received in the last hour:
scarywood75
Scarlett Johansson
Just a reminder or maybe you don't know much this forum yet, but people here don't care about safety.
They're gonna complain if the product they receive is not 99% pure, or is under filled. But they're gonna use 3 months old BAC water punctured a trillion time to reconstitute and use the same vial to draw and inject from every week. Reconstituting in a non sterile environment without swabbing the vials and things like that. Of course no filtration, no usage of any sterile standards cuz we have one life to live they say
People are cheaping out sooooo much on safety but they're gonna complain as soon as they receive a subpart product. It's almost like they think a quality product can replace safety procedure 😂
It's just mind blowing to me, that people think this way here, so of course when you bring anything about safety that'll complicate their stone age reconstitution process, you're not gonna be liked 🤣
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scarywood75
Scarlett Johansson
They'll think they are using more sterile procedure than people working in this field or vendors. For them, it's just totally normal to do it this way, they never died yet so it must be OK right?! Yet, they complain when the product stings or cause ISR 😂
Brother, I'm all but admitting I provoked you. All it took was a laughing emoji to do it. The emoji at first was laughing at your approach to having a conversation around what defines the word "turning", but it turned into trolling for me after that.
You think I'm all torn up about this, I'm not. If you truly aren't megalith, please pay attention to his approach and try to understand why the approach doesn't work for advancing discourse on a serious topic. Calling people ignorant and feeling the need to have a rebuttal for the simplest of comments.
Please, keep going. Keep providing little snippets of conversations. I'm not the one trying to convince a community with my research, you are. You then, by default, have a higher standard to be held to than I do when it comes to credibility on the interwebz.
I'm a dumb ass finance guy giving you a hard time...and it just doesn't click for you. The entire thread proves my point on your emotional intelligence and motivations.
The funniest part of all this....is I agree with your research possibly being correct and stated as such to begin with.
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No, that's not true. Your accusation that no one is discussing your original post.
I've asked you for citation [5] and I haven't heard back.
I also wanted to discuss the study where Cagri is referenced as Compound 23 and it did form some fibrils after 45 hours mechanical stress while at pH 7.5
I'm definitely on the more receptive side of the science being discussed here, but this sort of posting isn't going to win people over. The people that are against you will think you can just easily make them up, and people regardless are very rarely persuaded by random quotes of what other people have to say about you.
Everyone arguing against you is doing it based off of reasons that will not be swayed even if a bunch of people were actively posted in your favor publicly in this thread, and it just comes across as weird and defensive to post them yourself.
Just leave the discussion to the science. If people disagree with you, point out, with references, why they're wrong. The rest of this is just you getting baited into other nonsense.
It's perhaps even more complicated than just the pH level.
The patent discusses testing they did at pH 4 with various buffers - https://patents.google.com/patent/US20230082544A1/en
Go to [0488] and begin reading, particularly through [0540] - we see that even at a 4.0, different buffers have different levels of fibril formation. Benzoate being the worst, glutamate being the best.
If fibrils are a health concern - and I really have no idea on the science here on if they are or aren't - I think we would need confirmation that the pH and buffering agents are both of the "correct" value/type. It looks like even adding too much buffering agent can also increase fibril formation, though this seems to be less of an issue vs. just the "wrong" PH or agent.
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None of us here are actual experts on any of this, which is unfortunate because people reading these threads are going to take a lot of what is said here to heart and feel some measure of confidence in things just because people who seemed better informed on a subject wrote out a forum message.
Obviously, we're all signing up for taking significantly enhanced risks in buying vials of white powder from china, reconstituting then, and injecting them. No one should be doing any of this if they're not willing to do the calculus there and decide it's within their risk tolerance.
But I also think we should take potential health concerns with what appears to be directly referenceable science backing them seriously and discuss those as best we can with the level of understanding we have, regardless of whether or not some of the people involved in the discussion might drive us up the wall with how they argue.
Obviously, we're all signing up for taking significantly enhanced risks in buying vials of white powder from china, reconstituting then, and injecting them. No one should be doing any of this if they're not willing to do the calculus there and decide it's within their risk tolerance.
But I also think we should take potential health concerns with what appears to be directly referenceable science backing them seriously and discuss those as best we can with the level of understanding we have, regardless of whether or not some of the people involved in the discussion might drive us up the wall with how they argue.
I wish as well. There’s a few on this forum that have a habit of being contentious while ignoring actual issues of discussion. Someone took the time to put helpful material together and then the opening salvo from one individual is to start attacking who he or she is while really adding nothing of substance to the conversation. I feel sad saying this because I’ve always found this forum to be helpful but there’s been lots of degradation in utility over the last few weeks. Can we just stop these personal attacks and get back to useful discussion??
