scarywood75
Scarlett Johansson
You guys and girls had a rough week, it's time to let it all out 😎
You seem to have a weird fibril fetish and are well known for it in the community. I’m pretty sure others have already tried to talk you down so I won’t waste my breath. I will refer you to my previous comment and cited article.I literally just shared direct quotes from Novo Nordisk about their own drug. Which of their statements do you consider 💩?
Who are you to judge people's fetishes, I'm sure you have some too 😶🌫️You seem to have a weird fibril fetish and are well known for it in the community. I’m pretty sure others have already tried to talk you down so I won’t waste my breath. I will refer you to my previous comment and cited article.
I don’t care what anyone else’s fetishes are as long as they don’t try to force it on anyone else.Who are you to judge people's fetishes, I'm sure you have some too 😶🌫️
Oh yeah I'm sure everyone here really feel forced 🤣I don’t care what anyone else’s fetishes are as long as they don’t try to force it on anyone else.
Hehe, take good informations and just discard the rest, I don't bother sharing anything anymore like a ton of good members hereThis forum fucking sucks.
And the worst thing of all it's the best GLP1 forum there is.
Fuck.
I already linked to this article in my original post and heavily quoted from it, as well as several other sister reports from Novo. Clearly you never read my post to begin with if you think your post somehow counters it. 🙃For the chemistry majors here’s research article about amylin and fibrils. For the TL;DR, yes fibrils were a concern which is why modifications have been made to cagri to suppress fibril development. You can scroll to the summary at the end if chemistry isn’t your thing.
I admire your persistence sir/mamI already linked to this article in my original post and heavily quoted from it, as well as several other sister reports from Novo. Clearly you never read my post to begin with if you think your post somehow counters it. 🙃
You don't need to follow safety advices, nobody is forcing you to, hopefully you'll sleep well anyway 🙏If you keep reading you can see that I did, with a cited article. I think qualligator.com will be much more receptive to this post.
You cited the same article that I already cited first. It's literally the first link on my list of citations.If you keep reading you can see that I did, with a cited article. I think qualligator.com will be much more receptive to this post.
Then I don’t think you understood the article. What exactly are your concerns? Even if your cagri did have fibrils, they will not cross the blood-brain barrier or enter into your bloodstream. Maybe you’d get an ISR which plenty of people already get with tirz. No human trials to date have shown any amyloid fibrillation formation.I already linked to this article in my original post and heavily quoted from it, as well as several other sister reports from Novo. Clearly you never read my post to begin with if you think your post somehow counters it. 🙃
You’re right I diid not closely read his lengthy post but I have seen this around elsewhere. The chemistry article does not support his fibril fears IMO.You cited the same article that I already cited first. It's literally the first link on my list of citations.
Except it proves my point, not yours. 🙃
You're missing the point he's making, try againThen I don’t think you understood the article. What exactly are your concerns? Even if your cagri did have fibrils, they will not cross the blood-brain barrier or enter into your bloodstream. Maybe you’d get an ISR which plenty of people already get with tirz. No human trials to date have shown any amyloid fibrillation formation.
Then I don’t think you understood the article. What exactly are your concerns? Even if your cagri did have fibrils, they will not cross the blood-brain barrier or enter into your bloodstream. Maybe you’d get an ISR which plenty of people already get with tirz. No human trials to date have shown any amyloid fibrillation formation.
“Some of these toxic oligomeric species are associated with beta-cell death and the progression of type 2 diabetes (16−18)”
Here, they cite research showing that not fibrils, but toxic oligomers are what cause the death of the insulin-producing beta cells in the pancreas. This is from the first study cited:
Once again, I'm not concerned in the slightest about fibrils.You’re right I diid not closely read his lengthy post but I have seen this around elsewhere. The chemistry article does not support his fibril fears IMO.
You are very confused...Then I don’t think you understood the article. What exactly are your concerns? Even if your cagri did have fibrils, they will not cross the blood-brain barrier or enter into your bloodstream. Maybe you’d get an ISR which plenty of people already get with tirz. No human trials to date have shown any amyloid fibrillation formation.
You're fighting over something that was not even a concern raised by OP, maybe you should've read itYou’re right I diid not closely read his lengthy post but I have seen this around elsewhere. The chemistry article does not support his fibril fears IMO.
oh yay...we have a moderator now! Our cherub of justice could use the help!This Cagri stuff is everywhere I go.
You didn't answer my question. Not that I expected you to.You are very confused...
My concerns are in my original post. Read that, and your question is already answered. 🙄You didn't answer my question. Not that I expected you to.
We went over this in the other thread - that is not what this section says. The table with the ThT assay results specifically shows they were able to form fibrils at 7.5View attachment 4063
Don't they speak to the different pH levels (4 and 7.5) while subjecting Cagri to mechanical stress?
And they couldn't form any fibrils? Are you saying that this is incorrect and they didn't use the right equipment to test for formation of harmful molecules?
I don't know if fibrils (or oligomers) are of concern but y'all need to stop sharing this link acting like it says cagrilintide does not form fibrils at 7.5, because the paper explicitly says that it does.For the chemistry majors here’s research article about amylin and fibrils. For the TL;DR, yes fibrils were a concern which is why modifications have been made to cagri to suppress fibril development. You can scroll to the summary at the end if chemistry isn’t your thing.
We went over this in the other thread - that is not what this section says. The table with the ThT assay results specifically shows they were able to form fibrils at 7.5
Here's exactly what happened.All but convinced this is megaliths original discord username and megalith was his alt for peptide purposes. Even went back and compared grammar and writing styles.
Last night, I applauded him for his compilation of research and conclusions, but yet he just couldn't stop responding over if we believed the peptide community was "turning" toward accepting the conclusions.
Both he and megalith (if they are even two different people) care more about being seen as the smartest person in the room and attacking others in a derogatory manner than they do about letting the science speak for itself.
No one will ever take either of them seriously because of their approach. Put your ego(s) aside and try to have some discourse. Both of you are way too in your feelings on the topic and it hampers credibility.
Even if I said the conversation didn't need to continue, as we were aligned on the science, but not aligned on the "community" changing their opinion, he still simply couldn't let it go and reiterated a point that had nothing do with what we weren't agreeing on.
The loudest person in the room is never the smartest. If you aren't megalith, maybe learn from his mistakes and try a different approach.
There's a difference between "turning" and "turned" that you seem to be conflating. For cagrilintide promos to stop selling out would indicate it has completely "turned." Whereas pH buffered cagrilintide now being offered is a sign that it's "turning." So yes, it's turning, but still plenty of people behind the curve.
You set the tone when you laughed at my comments attempting to substantiate the turning of the tide (and it is turning). I don't mind, but don't clutch pearls when I respond in kind.
Except you already take me seriously. You praised my write-up repeatedly and described it as "persuasive."No one will ever take either of them seriously because of their approach.
I can’t speak for everyone, but personally I have no problem with the idea that cagri could have some requirement to be reconstituted at a certain ph for efficacy or safety or both. It’s something that should be discussed.
However, the origin of it (as I gather you’re well aware) was based on a sloppy mess of megalith’s chatgpt theories that didn’t pass muster, and since then the topic has been a magnet for “I am very smart, don’t my farts smell nice?” blowhards. My pushback on OP was not about the content of his community college analytical commentary of some research papers, it was the joining a forum and being a giant asshole in the first post. It was particularly triggering because how on-brand it was for these cagri ph guys.
Here he goes again. Even after I agreed with him again in the post on it being persuasive. But I had reached the conclusion before your write up. So please don't give yourself to much of a pat on the back.Here's exactly what happened.
I said the tide has been turning of late about this cagrilintide topic.
You denied it.
I said maybe you're just not up to date, and I pointed to evidence: multiple people within the chat including the server owner who said they had finally been persuaded by my recent write-up (the same one I posted here).
You mocked my response with a laugh-react (🤣) and then once again denied that the tide was turning, citing the cagrilintide promos that had been selling out as evidence.
My response:
Then you got defensive and accused me of being "condescending" because I said "you seem to be conflating." But you did conflate them, and as I responded:
And now, here you are dragging this petty grievance onto another platform, acting like a victim when you started with the mocking and couldn't handle a little "condescension" in return.
The tide *is* turning and you loudly denying it across multiple platforms ain't gonna change that.
And now you say:
Except you already take me seriously. You praised my write-up repeatedly and described it as "persuasive."
That's one more person publicly aligning themselves with Novo Nordisk, demonstrating the continued turning of the tide. 🌊
You conveniently omitted the part about vendors now offering pH-buffered cagrilintide, in response to demand from customers.Here he goes again. Even after I agreed with him again in the post on it being persuasive. But I had reached the conclusion before your write up. So please don't give yourself to much of a pat on the back.
I told you and stated above I don't think anything is turning in the community. And your diatribe is just even more reason why it won't turn. For fucks sake. 3 people messaging you and you typing up a summary isnt enough to constitute turning in my opinion.
You and megalith both have the emotional intelligence of a 5 year old. Yall care more about being seen as credible than you do just being a contributor. You're doing more harm than good
All it takes is a laughing emoji to get both he and megalith in their feelings🤣
There's a difference between "turning" and "turned" that you seem to be conflating.
Never did i cry about anything. The whole comment on condescending with "ey" at the end of it was to point out how similar you and megalith are. And why I think you're the same person. You can't see that. Haha. Someone can go on the Swiss and see the interaction. You will continue to respond even when the conversation doesnt need to continue. You can't walk away. Too much emotionI am "in my feelings" because I said the following to you?
After which you cried about me being condescending? Textbook case of projection.
You were so butthurt that you had to go whine about me being "condescending" on another platform. 🤣
No, I'm here to talk science. Are you?@secretweapon is obviously just here to argue in a combative fashion, it is what he does on other platforms as well. I'll permit it in this thread only. Have at it, don't spread to other threads.
Do you lie about people on other platforms too or just this one?@secretweapon is obviously just here to argue in a combative fashion, it is what he does on other platforms as well.
That's how I conduct myself on other platforms. But when people completely ignore the science and just talk shit like you've done? Don't play innocent and pretend that you didn't provoke it when it comes back to you.I’m appreciating @secretweapon sharing a lot of this info. He’s never been insulting or arrogant. He cites tons of research and simply replies and posts with a lot of back up.
Nobody is discussing the material in your post. Odd.
You're being gaslit over there, it's not all in your head lol
Just a reminder or maybe you don't know much this forum yet, but people here don't care about safety.Do you lie about people on other platforms too or just this one?
In response to @nccane on that other platform, someone had this to say:
That's how I conduct myself on other platforms. But when people completely ignore the science and just talk shit like you've done? Don't play innocent and pretend that you didn't provoke it when it comes back to you.
Brother, I'm all but admitting I provoked you. All it took was a laughing emoji to do it. The emoji at first was laughing at your approach to having a conversation around what defines the word "turning", but it turned into trolling for me after that.Do you lie about people on other platforms too or just this one?
In response to @nccane on that other platform, someone had this to say:
That's how I conduct myself on other platforms. But when people completely ignore the science and just talk shit like you've done? Don't play innocent and pretend that you didn't provoke it when it comes back to you.
DMs from two different people I've received in the last hour:
We went over this in the other thread - that is not what this section says. The table with the ThT assay results specifically shows they were able to form fibrils at 7.5
I'm definitely on the more receptive side of the science being discussed here, but this sort of posting isn't going to win people over. The people that are against you will think you can just easily make them up, and people regardless are very rarely persuaded by random quotes of what other people have to say about you.DMs from two different people I've received in the last hour:
It's perhaps even more complicated than just the pH level.EDIT: Nevermind. I used chatgpt to help sort out this study... Here's what it said...
While the results indicate that Compound 23 did not entirely avoid fibrillation at pH 7.5, it demonstrated delayed onset and moderate recovery, making it less prone to fibrillation than many other analogues. However, this performance still falls short of the study's ideal metrics for fibrillation resistance.
Why Was This Tolerated?
The study's authors prioritized stability under the intended formulation conditions (pH 4.0), where Compound 23 performed well:
- At pH 4.0, Compound 23 exhibited a long lag time (45 hours) and high recovery (96%), indicating robust stability in the acidic conditions planned for its use.
- The lower pH mitigates fibrillation risk during storage and administration, making it clinically acceptable despite its suboptimal performance at pH 7.5.
Conclusion:
Yes, Compound 23 formed fibrils at pH 7.5, as evidenced by the lag time and reduced peptide recovery in the assay. However, its overall performance across conditions and suitability for acidic formulations justified its selection for clinical development.
I wish as well. There’s a few on this forum that have a habit of being contentious while ignoring actual issues of discussion. Someone took the time to put helpful material together and then the opening salvo from one individual is to start attacking who he or she is while really adding nothing of substance to the conversation. I feel sad saying this because I’ve always found this forum to be helpful but there’s been lots of degradation in utility over the last few weeks. Can we just stop these personal attacks and get back to useful discussion??Really wish we'd spend more time focused on what the OP has written and backed up with scientific evidence, rather than the OP himself.
Because this shit is pretty scary, I know we're used to all sorts of peptides of unknown benefit or harm, but here it seems we have a peptide with a likely known harm.