In Novo’s Own Words: Degradation of Amylin Analogs Such as Cagrilintide (and How to Test For It)

[secretweapon]

Really wish we'd spend more time focused on what the OP has written and backed up with scientific evidence, rather than the OP himself.

Because this shit is pretty scary, I know we're used to all sorts of peptides of unknown benefit or harm, but here it seems we have a peptide with a likely known harm.

I sure thought that was strange. I took myself out of the equation by making it all about direct Novo quotes and people still want to shoot the messenger.

 

[secretweapon]

That's just the fibrils oligomers making you think that.

that was funny the other 10 times you said it in Discord.

 

[Yay-Z1]

Quick Google search on Cagri and Fibrils.


This is obviously an AI summary.

 

[secretweapon]

Quick Google search on Cagri and Fibrils.

View attachment 4064
This is obviously an AI summary.

What's the point in sharing this?

Novo themselves literally said Cagrilintide forms fibrils.

 

[Yay-Z1]

Could yall be confusing Cagri with Pramlintide

 

[secretweapon]

 

[secretweapon]

Could yall be confusing Cagri with Pramlintide

Here's something I wrote. Does it answer your question?

Cagrilintide retains the three proline substitutions that pramlintide made to human amylin to make it resistant to fibrillation, but it has four more improvements:

1. While pramlintide has a short half-life and must be dosed multiple times per day, researchers created a long-acting version that allows once-weekly dosing by adding a long fatty acid chain to the pramlintide molecule. The fatty acid allows cagrilintide to bind to albumin (a protein in the blood). When bound to albumin, cagrilintide is cleared from the body more slowly.
2. Researchers made cagrilintide resistant to a chemical reaction called deamination, which can break down the molecule, by replacing the asparagine amino acid (Asn) at position 14 with glutamic acid (Glu). Note: deamiNation is a distinctly different process from deamiDation (the latter leading to fibrillation).
3. They also made cagrilintide more soluble, meaning it dissolves more easily in water, by replacing valine (Val) with arginine (Arg) at position 17.
4. While pramlintide is a single-hormone agonist for amylin receptors, cagrilintide is a dual-hormone agonist for both amylin and calcitonin receptors. This is due to proline (Pro) being replaced by Tyrosine (Tyr) at position 37.

Those are the only four changes made to pramlintide to create cagrilintide. One important thing to note is that none of the changes made pramlintide more resistant to fibrillation or more stable at a higher pH. This means that any research on the pH requirements or fibrillation of pramlintide will also apply to cagrilintide.

 

[scarywood75]

View attachment 4065

Don't bother making these types of posts here, people are very closed mind as soon as you do things/think differently, even if it's for the better.

I'm a living proof of that too 😂

 

[nurseratchit]

@secretweapon sorry who are you? You just joined today to post this, and your conclusion is that people who disagree with your assessment have ulterior motives?

I think he’s megalith. He’s been busy spreading this 💩 in multiple places.

 

[nurseratchit]

I

that was funny the other 10 times you said it in Discord.

It was funny the other 10 times you spewed this nonsense in Discord

 

[secretweapon]

I think he’s megalith. He’s been busy spreading this 💩 in multiple places.

Yeah, a handful of people still can't tell we have entirely different personalities, but most people have it figured out.

 

[secretweapon]

I think he’s megalith. He’s been busy spreading this 💩 in multiple places.

I literally just shared direct quotes from Novo Nordisk about their own drug. Which of their statements do you consider 💩?

 

[Yay-Z1]

View attachment 4065

Seems like this is what you and Megalith default to when anyone shares something different from y’all’s view. Have a good day, I had a nice laugh .

 

[Dee X]

Don't bother making these types of posts here, people are very closed mind as soon as you do things/think differently, even if it's for the better.

I'm a living proof of that too 😂

You had ChatGPT inventing untested ways of reconstitution that didn't involve BAC, and decided to then have it write up a giant guide about how to do it as if it were proven in trials.

 

[scarywood75]

You had ChatGPT inventing untested ways of reconstitution that didn't involve BAC, and decided to then have it write up a giant guide about how to do it as if it were proven in trials.

This thread is getting spicy, let's bring some popcorn and watch 👀

 

[secretweapon]

Seems like this is what you and Megalith default to when anyone shares something different from y’all’s view. Have a good day, I had a nice laugh .

Maybe you should stop defaulting to sharing misinformation? 🤔

 

[scarywood75]

It's time to shine before an admin locks this thread again, adding to the drama is the only reason I'm commenting here, like all these comments lol

Nice write up btw

 

[nurseratchit]

Y

Don't bother making these types of posts here, people are very closed mind as soon as you do things/think differently, even if it's for the better.

I'm a living proof of that too 😂

I’ll admit to being close-minded to fear-mongering AI generated conspiracy propaganda.

 

[nurseratchit]

For the chemistry majors here’s research article about amylin and fibrils. For the TL;DR, yes fibrils were a concern which is why modifications have been made to cagri to suppress fibril development. You can scroll to the summary at the end if chemistry isn’t your thing.

https://doi.org/10.1021/acs.jmedchem.1c00565

 

[scarywood75]

Y

I’ll admit to being close-minded to fear-mongering AI generated conspiracy propaganda.

Oh no 😢

 

[scarywood75]

You guys and girls had a rough week, it's time to let it all out 😎

 

[nurseratchit]

I literally just shared direct quotes from Novo Nordisk about their own drug. Which of their statements do you consider 💩?

You seem to have a weird fibril fetish and are well known for it in the community. I’m pretty sure others have already tried to talk you down so I won’t waste my breath. I will refer you to my previous comment and cited article.

 

[scarywood75]

You seem to have a weird fibril fetish and are well known for it in the community. I’m pretty sure others have already tried to talk you down so I won’t waste my breath. I will refer you to my previous comment and cited article.

Who are you to judge people's fetishes, I'm sure you have some too 😶‍🌫️

 

[nurseratchit]

Who are you to judge people's fetishes, I'm sure you have some too 😶‍🌫️

I don’t care what anyone else’s fetishes are as long as they don’t try to force it on anyone else.

 

[penewbie]

This forum fucking sucks.

And the worst thing of all it's the best GLP1 forum there is.

Fuck.

 

[scarywood75]

I don’t care what anyone else’s fetishes are as long as they don’t try to force it on anyone else.

Oh yeah I'm sure everyone here really feel forced 🤣

 

[scarywood75]

This forum fucking sucks.

And the worst thing of all it's the best GLP1 forum there is.

Fuck.

Hehe, take good informations and just discard the rest, I don't bother sharing anything anymore like a ton of good members here

You gotta think like the rest of them, play along

 

[scarywood75]

It's like a sect almost 🫠

 

[secretweapon]

For the chemistry majors here’s research article about amylin and fibrils. For the TL;DR, yes fibrils were a concern which is why modifications have been made to cagri to suppress fibril development. You can scroll to the summary at the end if chemistry isn’t your thing.

https://doi.org/10.1021/acs.jmedchem.1c00565

I already linked to this article in my original post and heavily quoted from it, as well as several other sister reports from Novo. Clearly you never read my post to begin with if you think your post somehow counters it. 🙃

 

[scarywood75]

I already linked to this article in my original post and heavily quoted from it, as well as several other sister reports from Novo. Clearly you never read my post to begin with if you think your post somehow counters it. 🙃

I admire your persistence sir/mam