Exactly this is the reason why... Where do you want to go from here? To 18mg? 12mg? People in the studies had severe side effects from higher dosage. Not just nausea but effects on the skin, they had to "fight" with antihistamines.
I think, the better idea is to find out, why "nothing" happened. And what is "nothing". No hunger suppression? Then Cargi might be the was to go. Or even Triz.
If nothing is happening, it might be, that the GLP-1 receptors are over saturated / stressed. And they protect themselves from Reta.
Oh man, what a wonderfully respectable disposition. It's such a breath of fresh air. I had almost lost hope for the species with the way some of the more vociferous denizens here behave. Fortunately for me, there is one friend who I used to argue with a lot when we were in college. Frustratingly, the bugger is a lot smarter than I am. Took me a long time to acknowledge that, but thank heavens, I did. He is the one who got me onto GLP's. Now I did a lot of the reading on the subject, reasonably so for an amateur, however, because I wasn't intellectually challenged, I decided to follow my friend's strategy. This is how it goes.
I'm using Reta to lose weight. That's the fundamental goal. Everything else is complementary. It is generally accepted that a weight loss rate of 2lbs per week is safe. There are people in here who have had gall bladder issues with losing weight faster. Yeah, no thanks! I began with a 1mg dose and just had my 8th dose a few days ago at 2.5mg. In 58 days, I have lost 22lbs. That's a mean weight loss of 0.38lbs daily. This comes up to a weekly loss of 2.65lbs. That is already on the high side. At this stage apart from the constipation, I have no sides. I could raise my dose to 4mg and opt for a quicker weight loss, but just like the creator of this strategy said, "Why the hell would I?"
Compound desensitization is real. People titrate to higher amounts when they can tolerate the sides. Great, but I haven't heard much about people benefiting from GLP's with the same efficacy when they lowered their dose after their body got used to higher amounts of the drug running consistently in their bodies. There is also the issue with the one week half life. If you catch a nasty side effect, it will last for several days.
Thus, if your goal is to lose weight and keep it off, your suggestion for using Cagri was prudent. It is what I am doing at a 0.25mcg dose. That hunger suppression can keep the deficit going. Now, it is possible that the Glucagon activation that mirrors the natural pulse rate of the hormone occurs at 4mg for Reta, but is that really all that relevant IF I am already achieving the weight decline at a substantial rate?
Now of course, there are exceptions to this. If someone has a huge amount of weight they need to discard, then of course, they should risk using a larger dose to lose weight quicker before the final weight loss plateau arrives. Originally I had a target of 60lbs I wanted to lose. I have lost 22.
For that mate of mine, he is on the same Reta dose and when his daily weight loss stalled for 6 days, he didnt use Cagri, and he used a common ergogenic supplement and boom, started losing weight again. His reasoning? He got his Reta for around 88cents per mg. That ergogenic compound was 6 cents per capsule. One a day led to 42 cents a week. And there is no eventual desensitization to it. And it brought him nootropic effects too, so it was a no-brainer [pun intended]. How can you argue with that?
I am definitely going to continue this strategy. As long as I am losing weight at a slightly higher rate than 2lbs per week, I am going to use the most minimal dose. I don't suffer from the solipsistic dysfunction caused by cerebral deficiency to think that just because someone else lost weight with no sides at a huge dose, that is the optimal routine for me to follow just because those people have existed in a space for a longer duration.
