Surprisingly, I have very bad sides from medications also, but NOTHING from peptide-based ones. I was bedridden for three days couple years ago when I started 10mg Cialis (for prostate health), and lethargically tired and major muscle pain/weakness when started Lipitor. I had to actually stop both. I've been able to start Cialis at 2.5mg with little sides and very happy about it since I have a very bad history of prostate issues in the family. I think I'll keep experimenting with peptides for various benefits since I seem to handle them really well.