Nexaph Reta 12 mg - neon green cap under- performing 89-92 % re-testing

morganite

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To whoever comes across these vials ....
A group of us who bought Reta 12 mg / neon green caps, purple crimp in October 2024 decided to re-test the batch as it was originally under - performing at 97 - 98 % purity. With the help of Sabrina F, who has lab access we sent in a bunch of vials and got the results today. I am posting Sabrina's comments with her test results here. I am sincerely hoping that none of us in this community will be tempted to use this product and I am also hoping that , by making the test results public that we will spot it right away if someone should try to sell it anywhere in the servers.
To be fair to Cain and Nexaph, the Reta got re-shipped /replaced to all of us who bought it.

Attached you find the test results that were completed today.

Here are Sabrina's comments, I have her permission to share them with you:
"I won’t make any bold claims as to what is going on. The tests indicate:
Degradation due to oxidation
Possibly worsened by the fact that this might be Na form of the compound
Degradation has caused some changes in sensitive residues which usually happens when a peptide degrades
NMR showed a degradation of the product (point in time) of about 89-92% (again this is not HPLC)
Mass does not conform but this is what we have been seeing in many other tests the mass around ~4728-4730 g/mol. Per ICH standards this is off, per research guidelines it’s fine. Purity per research standard passes for both MS and NMR. No TFA detected.

Again everyone has their own tolerance risks, this is just the tests results at this time to how they showed up. Might have been better before might be the same or worse later we won’t know if we do not test.

I try to be as objective and scientific while providing explanations that make sense."
 

Attachments

giphy-downsized.gif
 
Her test results seem to conflict with those from PT/TP. View attachment 4229
As already previously stated... your reta results are from the new , re-shipped batch ... green, not neo green.... Attached are the original results from the NEON green batch, BEFORE the Reta degraded by another 10 % within a month..... And yes, it is SHOCKING how far test results can be apart.....
 

Attachments

As already previously stated... your reta results are from the new , re-shipped batch ... green, not neo green.... Attached are the original results from the NEON green batch, BEFORE the Reta degraded by another 10 % within a month..... And yes, it is SHOCKING how far test results can be apart.....
Here is another test the Reta GB did on the degraded Reta, note how it degraded about 1% further in 18 just days. There is always variability in purity testing across labs so I wouldn't say Numega labs purity is exactly as stated, but I do believe they have demonstrated the purity of this product has degraded significantly roughly 30 days after the latest Jano test.

1733489006361.png
 
Agreed. As short and tumultuous as nexa’s track record is, this lab’s seems to be shorter and even less steady. Testing w Jano, or at least with one of the domestic labs, is needed for sure.
This was retested with Jano also and is only getting worse. The numega labs reports are confusing but I'm sure its not far off in this case.

I've used this batch and after being reconstituted it was less potent like a week or two later. His new batch tested lower than other vendors reta too (99.1% vs most vendors seem to be able to get around 99.5%+). I wouldn't be shocked if a month later the SNP reta is around 98% and still has the same issues as the first batch.

To add, I'm not a nexaph hater too lol. I bought a bunch of stuff from them but they do seem to have a degradation issue that happens later on with some of their peptides. I stopped buying anything new until they sort this out. They also are basically a pre-pay group buy now so I don't even get 2 day shipping so there's no point.
 
I actually have an overarching theory for Nexaph, just a theory, but I've been kicking it around fo a while and it seems more plausible as more evidence comes out. I’ll show all the evidence I’ve found for it.

Here is the theroy: At least a sizeable portion of Nexaph products are QC fails from several Chinese factories that they get at a very low price. See this post from Zippity regarding new domestic vendors selling QC factory fails for high profit (apparently it’s really common).

It's well known to those of us who have been around this hobby since early on that most of the Chinese fill & finish houses liquidate their QC fails to any number of the pop-up trading companies who then in turn sell in bulk to US vendors (usually start-ups)


Now the evidence:

First, rapid degradation is common when a peptide isn’t finished correctly, and this could account for the numerous 2nd and 3rd party test discrepancies. It could be the peptides degrade a couple % in a month or so. Improperly finished peptides are definitely a QC issue and most factories couldn’t sell these at regular price. In fact Cain has even acknowledged that rapid degradation is causing the 2nd/3rd party test mis-matches and this threads OP further corroborates this.

Second, I mentioned this alread elsewhere, but there have also been multiple reports of bad crimps and loose caps, which are also QC issues. @zpped and @peptideusername have posted pics of this elsewhere so hopefully they can post here too. I've never heard reports of this type of thing from other vendors either.

Third, if they are selling QC fails it would also explain why they are constantly running out of stock. Their stock would be limited by how frequently whichever Chinese factories they work with screw up. Nexaph has been around long enough to get their supply issues sorted by now, the fact that they haven’t is a red flag.

Fourth, it would also explain why they can offer the lowest prices of any domestic vendor, still offer guarantees and remain profitable. If they are selling QC fails I’m sure they get them for next to nothing. And while some may take advantage of their guarantees, I’m sure many more do not, so even if they refund or replace some questionable products, they can still turn a profit. Even if they replace the occasional batch, they could still turn a profit if they get the products cheap enough and if they test fast enough this problem won't be obvious in most cases.

Fifth, before it was outed that Nexaph was domestic Cain argued on Meso that they must be a Chinese company because they wouldn’t be profitable at their prices otherwise. And he was right, it wouldn't be possible to be profitable at their prices (which are the lowest of any domestic vendor by far) unless they are getting their stock at next to nothing. And I’m sure QC fails can be bought wholesale for next to nothing.

Sixth, one last thing, this theory could also explain the use of the histidine filler Cain claimed to use (and subsequently denied if you believe that....). Jano has pointed out this filler can be used to hide impurities, so this unusual filler could have been used by the finisher to cover up some type of impurity in a bad batch of raws, which would make it harder to detect in testing. This would also be the type of sub-par product sold in bulk at a much lower price.

As mentioned before, this is just a theory, but it is not baseless, I showed the evidence. I've suspected this for months now and as time goes on there seems to be more and more evidence for it. Also, as reported by Gonk, it’s common practice among newer domestic vendors.
 
I actually have an overarching theory for Nexaph, just a theory, but I've been kicking it around fo a while and it seems more plausible as more evidence comes out. I’ll show all the evidence I’ve found for it.

Here is the theroy: At least a sizeable portion of Nexaph products are QC fails from several Chinese factories that they get at a very low price. See this post from Zippity regarding new domestic vendors selling QC factory fails for high profit (apparently it’s really common).




Now the evidence:

First, rapid degradation is common when a peptide isn’t finished correctly, and this could account for the numerous 2nd and 3rd party test discrepancies. It could be the peptides degrade a couple % in a month or so. Improperly finished peptides are definitely a QC issue and most factories couldn’t sell these at regular price. In fact Cain has even acknowledged that rapid degradation is causing the 2nd/3rd party test mis-matches and this threads OP further corroborates this.

Second, I mentioned this alread elsewhere, but there have also been multiple reports of bad crimps and loose caps, which are also QC issues. @zpped and @peptideusername have posted pics of this elsewhere so hopefully they can post here too. I've never heard reports of this type of thing from other vendors either.

Third, if they are selling QC fails it would also explain why they are constantly running out of stock. Their stock would be limited by how frequently whichever Chinese factories they work with screw up. Nexaph has been around long enough to get their supply issues sorted by now, the fact that they haven’t is a red flag.

Fourth, it would also explain why they can offer the lowest prices of any domestic vendor, still offer guarantees and remain profitable. If they are selling QC fails I’m sure they get them for next to nothing. And while some may take advantage of their guarantees, I’m sure many more do not, so even if they refund or replace some questionable products, they can still turn a profit. Even if they replace the occasional batch, they could still turn a profit if they get the products cheap enough and if they test fast enough this problem won't be obvious in most cases.

Fifth, before it was outed that Nexaph was domestic Cain argued on Meso that they must be a Chinese company because they wouldn’t be profitable at their prices otherwise. And he was right, it wouldn't be possible to be profitable at their prices (which are the lowest of any domestic vendor by far) unless they are getting their stock at next to nothing. And I’m sure QC fails can be bought wholesale for next to nothing.

Sixth, one last thing, this theory could also explain the use of the histidine filler Cain claimed to use (and subsequently denied if you believe that....). Jano has pointed out this filler can be used to hide impurities, so this unusual filler could have been used by the finisher to cover up some type of impurity in a bad batch of raws, which would make it harder to detect in testing. This would also be the type of sub-par product sold in bulk at a much lower price.

As mentioned before, this is just a theory, but it is not baseless, I showed the evidence. I've suspected this for months now and as time goes on there seems to be more and more evidence for it. Also, as reported by Gonk, it’s common practice among newer domestic vendors.
Alternatively, maybe they are in fact finishing some themselves in their garage and don’t know wtf they’re doing. Learning on the job while marketing yourself as equivalent to existing players is also common in this peptide gold rush, and works because so many customers are newbies so don’t recognize the difference between a recordless vendor and an established one. Trustpointe is a recent example of that phenomenon.
 
Alternatively, maybe they are in fact finishing some themselves in their garage and don’t know wtf they’re doing. Learning on the job while marketing yourself as equivalent to existing players is also common in this peptide gold rush, and works because so many customers are newbies so don’t recognize the difference between a recordless vendor and an established one. Trustpointe is a recent example of that phenomenon.
I've seen that threroy discussed in discord land and agree it could also explain most of the issues I brought up. I just think the QC fails theroy is simpler so by ocams razor it's the one I believe.

On a side note, it is interesting bouncing from the more experienced discord communities where people are debating WHY nexaph's products are bad to here where people still debate IF their products are bad. It gives me whiplash at times.
 
I've seen that threroy discussed in discord land and agree it could also explain most of the issues I brought up. I just think the QC fails theroy is simpler so by ocams razor it's the one I believe.

On a side note, it is interesting bouncing from the more experienced discord communities where people are debating WHY nexaph's products are bad to here where people still debate IF their products are bad. It gives me whiplash at times.
Funny, I thought them just being bad at their job was the simpler explanation, you think reselling qc rejects is the simpler one. Someone needs to get Occam on here to settle this for us.

If we go with Hanlon’s Razor instead then the incompetence explanation wins.
 
Buying crap products from a factory is alot easier than making crap products yourself, no?
Sourcing QC rejects seems more unlikely to me than trying to lyo themselves. I know of others who have taken a stab at onshoring the fill and finish process (the bathtub guys whose name escapes me and bb aminos spring to mind), but have never heard of anyone trying to set up a business reselling qc rejects. Seems like it would be a nightmare for a bunch of reasons:
1. Do these suppliers even do QC in China? The bad batches seem to mostly get discovered by 3rd party testing, possible I just don’t have line of sight there though
2. Even though I don’t think he is especially smart, even baba would recognize that it would be problematic to sell known bad peptides with a purity guarantee. The guy has been in the testing servers for a long time and is well aware that people will be doing post-sale tests
3. Sitting around waiting for a bad batch of whatever to come along doesn’t seem like a very good business model.
 
1. Do these suppliers even do QC in China? The bad batches seem to mostly get discovered by 3rd party testing, possible I just don’t have line of sight there though
I'm going off what Zippity said in the pist linked above, and he thinks its common. I've seen the concept brought up more in discord land as well.

2. Even though I don’t think he is especially smart, even baba would recognize that it would be problematic to sell known bad peptides with a purity guarantee. The guy has been in the testing servers for a long time and is well aware that people will be doing post-sale tests
But again, if he gets them cheap enough it still could work out. Also if he tests them quickly enough, it won't be apparent immediately. Most domestic peptide business don't last more than a year or so and it takes time for issues like this to come out. Plenty of profit to make before people get wise and by then something else could shut them down.

3. Sitting around waiting for a bad batch of whatever to come along doesn’t seem like a very good business model.
But it's consistent with the constant out of stock issues they have.

Overall I do think alot of money could be made with a QC fails approach and it would require alot less effort than a diy homebrew lypho operation with similar profits.
 
I'm going off what Zippity said in the pist linked above, and he thinks its common. I've seen the concept brought up more in discord land as well.


But again, if he gets them cheap enough it still could work out. Also if he tests them quickly enough, it won't be apparent immediately. Most domestic peptide business don't last more than a year or so and it takes time for issues like this to come out. Plenty of profit to make before people get wise and by then something else could shut them down.


But it's consistent with the constant out of stock issues they have.

Overall I do think alot of money could be made with a QC fails approach and it would require alot less effort than a diy homebrew lypho operation with similar profits.
🤔 gotta open a peptide shop at the local outlet mall next to the Nordstrom Rack
 
The QC fails seems hard to believe because they replace the entire batch and have had to do this more than once. If the QC failed factory sells you cheap knowing its failed I doubt the factory replaces his kits for free. So he ends up paying for that.

I guess it depends how cheap we're talking too. Also hes technically not operating like a domestic vendor at this point. Everything lately is a prebuy. He can just as easily be using the presale money to hit a MOQ and order in bulk from any vendor. His prices are higher than china prices still. They're just cheaper than domestic single vial companies.
 
I'm going off what Zippity said in the pist linked above, and he thinks its common. I've seen the concept brought up more in discord land as well.


But again, if he gets them cheap enough it still could work out. Also if he tests them quickly enough, it won't be apparent immediately. Most domestic peptide business don't last more than a year or so and it takes time for issues like this to come out. Plenty of profit to make before people get wise and by then something else could shut them down.


But it's consistent with the constant out of stock issues they have.

Overall I do think alot of money could be made with a QC fails approach and it would require alot less effort than a diy homebrew lypho operation with similar profits.
When you say QC , what are you abbreviating? thanks 🙂
 
The QC fails seems hard to believe because they replace the entire batch and have had to do this more than once. If the QC failed factory sells you cheap knowing its failed I doubt the factory replaces his kits for free. So he ends up paying for that.

I guess it depends how cheap we're talking too. Also hes technically not operating like a domestic vendor at this point. Everything lately is a prebuy. He can just as easily be using the presale money to hit a MOQ and order in bulk from any vendor. His prices are higher than china prices still. They're just cheaper than domestic single vial companies.
This is my thinking as well. Group buys let's him purchase at the MOQ's using other peoples money. He typically charges about 1.5x CN vendor pricing and if he is making buy of 100 kits or more his pricing could be a lot better. Then he sometimes buys a couple of dozen extra kits to sell on his site, also using the pre-buy money. His costs are fairly low, $500 for a Jano test of three vials, shipping costs and whatever the site costs him to run. I think his product tests too well to be QC rejects. I may be. biased (or hopeful?) though because I have his kits in my freezer.
 
The QC fails seems hard to believe because they replace the entire batch and have had to do this more than once. If the QC failed factory sells you cheap knowing its failed I doubt the factory replaces his kits for free. So he ends up paying for that.

I guess it depends how cheap we're talking too. Also hes technically not operating like a domestic vendor at this point. Everything lately is a prebuy. He can just as easily be using the presale money to hit a MOQ and order in bulk from any vendor. His prices are higher than china prices still. They're just cheaper than domestic single vial companies.
That theory would explain why Cain is now stating that 98% purity is his new standard of acceptability .... is another reason for me not to buy from him till he clears up what's going on...
 
This is my thinking as well. Group buys let's him purchase at the MOQ's using other peoples money. He typically charges about 1.5x CN vendor pricing and if he is making buy of 100 kits or more his pricing could be a lot better. Then he sometimes buys a couple of dozen extra kits to sell on his site, also using the pre-buy money. His costs are fairly low, $500 for a Jano test of three vials, shipping costs and whatever the site costs him to run. I think his product tests too well to be QC rejects. I may be. biased (or hopeful?) though because I have his kits in my freezer.
But how do you account for all the problems with the products? I don't know of any Chinese factories that can't even consistently attach the caps correctly. This type of thing isn't typical of regular products.

And if he is ordering regular products in bulk WHY is he constantly running out of stock? He would be shooting himself in the foot by missing out on demand if all he has to do is order more. Alot of missed profit if that were the case.

Also prices for glps are a bit higher than China prices, but the non glps are neck and neck with China prices on the higher side (ASC is comparable price wise).

And regarding purity, the percentage should start high if using good raws, so if the test is done quickly it will come back fine. It's only once it's tested after a while that the degradation issue is apparent. This type of issue would take time to uncover, which seems to be happening now.
 
But how do you account for all the problems with the products? I don't know of any Chinese factories that can't even consistently attach the caps correctly. This type of thing isn't typical of regular products.

And if he is ordering regular products in bulk WHY is he constantly running out of stock? He would be shooting himself in the foot by missing out on demand if all he has to do is order more. Alot of missed profit if that were the case.

Also prices for glps are a bit higher than China prices, but the non glps are neck and neck with China prices on the higher side (ASC is comparable price wise).

And regarding purity, the percentage should start high if using good raws, so if the test is done quickly it will come back fine. It's only once it's tested after a while that the degradation issue is apparent. This type of issue would take time to uncover, which seems to be happening now.
These are the reasons I think he might be homebrewing at least some of the stuff. Nobody seems to believe thats possible though.
 
But how do you account for all the problems with the products? I don't know of any Chinese factories that can't even consistently attach the caps correctly. This type of thing isn't typical of regular products.

And if he is ordering regular products in bulk WHY is he constantly running out of stock? He would be shooting himself in the foot by missing out on demand if all he has to do is order more. Alot of missed profit if that were the case.

Also prices for glps are a bit higher than China prices, but the non glps are neck and neck with China prices on the higher side (ASC is comparable price wise).

And regarding purity, the percentage should start high if using good raws, so if the test is done quickly it will come back fine. It's only once it's tested after a while that the degradation issue is apparent. This type of issue would take time to uncover, which seems to be happening now.
Well, I am in a different industry than this.. but I can tell you... I have a bearing size I buy 10-15K a year for a certain customer from the same factory for the last 15 years. About 5 years ago I get an email from my customer that the c clips were not attached properly and they are falling off with the shields. I can't imagine as we have been supplying these for 10 years.. same factory, right? Well, I contact my agent, she contacts QC... and she thanks me and tells me a part on their machine in manufacturing is "broken". At this point.. do I believe them or not? Did "their" machine really have a discrepancy or are they buying from another manufacturer? They sent me another correct 10K relatively quick.

My point? Even if you go to China and inspect their facilities... in my industry, and all the rest, are extremely incestuous. They all make parts for each other, buy things from each other, etc. Hell, when I worked for a "domestic" manufacturer back in the day, we sold millions of dollars of green rings to a "domestic" manufacturer (our competitor) in MO from our Chinese joint venture. I know I have been doing business with the same 3-4 factories for the last 20+ years. I could buy products cheaper elsewhere but I have had ONE incident in all of this time. Do I believe everything they tell me? No.. because I know how they operate.
 
But how do you account for all the problems with the products? I don't know of any Chinese factories that can't even consistently attach the caps correctly. This type of thing isn't typical of regular products.

And if he is ordering regular products in bulk WHY is he constantly running out of stock? He would be shooting himself in the foot by missing out on demand if all he has to do is order more. Alot of missed profit if that were the case.

Also prices for glps are a bit higher than China prices, but the non glps are neck and neck with China prices on the higher side (ASC is comparable price wise).

And regarding purity, the percentage should start high if using good raws, so if the test is done quickly it will come back fine. It's only once it's tested after a while that the degradation issue is apparent. This type of issue would take time to uncover, which seems to be happening now.
I wonder how many crimp jobs are done using child labor.
 
Cain just put out a presale for Tesa and I don’t know if it is just me, but it looks like his prices are going up. Has anyone tracked this?
 
The full results that Sabrina F worked on for over a week (our testing group paid for the tests and paid for the vials, but her work was volunteered, a gift to us) was 6 mb and too big to upload here. If you are interested in seeing some of the results you can join the "Full Spectrum Testing server" on discord. Her tests are in a google folder that are shared in the server. Currently up for testing are Mots-C from several vendors, the GYC 40 mg Tirze and NAD+ from several vendors. Here is an invite link if you are interested: https://discord.gg/yguV4haC
 
Buying it from nexaph and following it up with a numega test result.

Really questioning the general publics decision making at this point.
It was throw-away Reta. If the test showed that there was no additional degradation it might have been free, usable Reta. Why not throw in a couple of bucks to see?

Also, purchased from a Raven GB that happened to be with the same supplier as Cain or maybe it was purchased through Cain, not sure at this point.
 
The full results that Sabrina F worked on for over a week (our testing group paid for the tests and paid for the vials, but her work was volunteered, a gift to us) was 6 mb and too big to upload here. If you are interested in seeing some of the results you can join the "Full Spectrum Testing server" on discord. Her tests are in a google folder that are shared in the server. Currently up for testing are Mots-C from several vendors, the GYC 40 mg Tirze and NAD+ from several vendors. Here is an invite link if you are interested: https://discord.gg/yguV4haC
I'm not following, what is Sabrina's relationship with this lab?

Because you've said she worked on these results for over a week, unpaid.
But Sabrina said this wasn't her lab nor was she affiliated with it.


This feels shady, I'm hoping there's a reasonable explanation.
 
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Buying it from nexaph and following it up with a numega test result.

Really questioning
It was throw-away Reta. If the test showed that there was no additional degradation it might have been free, usable Reta. Why not throw in a couple of bucks to see?

Also, purchased from a Raven GB that happened to be with the same supplier as Cain or maybe it was purchased through Cain, not sure at this point.
Just being funny. Don't expend too many iq points on me
 
I'm not following, what is Sabrina's relationship with this lab?

Because you've said she worked on these results for over a week, unpaid.
But Sabrina said this wasn't her lab nor was she affiliated with it.


This feels shady, I'm hoping there's a reasonable explanation.
From what I understand, Sabrina is a scientist that works in a lab but not the Numega lab used to test the reta. She recently started her own testing site on Discord and orders the testing from different labs depending on what she or users want tested. She gets the results back and then provides an analysis of the results.

Her idea was to go beyond mass/purity testing on the defunct reta to gain a better understand what is causing it to degrade so quickly and if it makes it completely unsafe to use. Typically when a pep degrades it loses its effectiveness, but in this case because it is degrading over weeks (instead of months) whatever is causing the degradation could be dangerous to inject. If this is the case, why did Nexaph/Cain/Baba use this formula in the first place.
 
From what I understand, Sabrina is a scientist that works in a lab but not the Numega lab used to test the reta. She recently started her own testing site on Discord and orders the testing from different labs depending on what she or users want tested. She gets the results back and then provides an analysis of the results.

Her idea was to go beyond mass/purity testing on the defunct reta to gain a better understand what is causing it to degrade so quickly and if it makes it completely unsafe to use. Typically when a pep degrades it loses its effectiveness, but in this case because it is degrading over weeks (instead of months) whatever is causing the degradation could be dangerous to inject. If this is the case, why did Nexaph/Cain/Baba use this formula in the first place.
Thank you for the clarification! From what I hear from her, she has received 25 hostile messages on discord since yesterday. Being a scientist who loves peptide and has put in many unpaid hours so far toward furthering understanding about the quality of our peptides, that really is discouraging.... I wonder, who would have a vested interest in discouraging her from doing this work???? hmmmmmmm..... I kinda do have a sense who might like her to stop..... alas, since a person can have many aliases around here, it's hard to say, isn't it?
 
I’m all for her doing her work but given the circumstances it’s not out of line to do a little side-by-side comparison between this brand new entrant and a trusted lab. That’s not slander, it’s just sensible. If she stands up under scrutiny then there is nothing to argue about. Until then though I’m remaining skeptical.
 
I’m all for her doing her work but given the circumstances it’s not out of line to do a little side-by-side comparison between this brand new entrant and a trusted lab. That’s not slander, it’s just sensible. If she stands up under scrutiny then there is nothing to argue about. Until then though I’m remaining skeptical.
I wouldn't pay her to do testing for me but I've been providing samples for her group. Stuff that's already been tested elsewhere.
 

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