It was on a private discord so it can’t be linked. You can ask him about it though if you’re on any forums where he participates.
Nexaph testing
- Thread starter DwightTheDelight
- Start date
Are you talking specifically about the mannitol in the Retatrutide? Or something else?
zpped
Registered
Mannitol is a standard excipient in glp1s. I'm talking about histidine
and as ewb said, jano said its a bad idea, it can hide impurities and interacts with glp1 in unpredictable ways.
noteablequotable
Registered
Look, Cain and I are not friends. I am an occasional customer who understands their background, and I continue to do business with them because I find the additional scrutiny they receive beneficial from a risk perspective. Whether or not you realize it this community has more leverage over Nexaph then we will EVER have over any other vendor specifically because their past behavior and that's very useful when it comes to extracting concessions on certain issues. I've intentionally shined a spotlight on him in the past to ensure forum members get the best possible outcomes for them (better than they'd get from any other vendor) and I like that dynamic a lot.
However, that only works because I'm precise in my criticism of them and I don't ask questions about their practices that I don't also ask about other vendors. It's clear that Cain used a different excipient than Janoshik expected with that batch of Tirz, but we have no evidence that it poses a risk to the health and safety of his customers, or might cause the Tirz to degrade more rapidly. We also don't know (and haven't asked) about the excipients other companies use. Maybe they use the same ones as Lilly, but maybe they don't. Maybe everyone is using different excipients based on what makes the most financial sense for them.
We know that AmoPure changed their excipients at least twice, and according to them the first change resulted in an increase in serious ISRs. There was certainly some talk about that, but no one put up any warnings about them. When I tried to get people to investigate those efforts fell flat. That was an obvious and immediate health and safety concern that was clearly related to the company's formulation (again, they admitted as much), and it never garnered this much suspicion or concern.
Can you share that information? I never saw Janoshik say anything about the excipient interacting with the GLP-1 in an unusual way. THAT would be very important and would definitely warrant investigation.
That's not why people continue to use Nexaph. People choose Nexaph because he meets their standards for quality, safety and convenience. I've never seen a test results below 98%, always reasonable fill, his products don't give weird ISRs or unexpected sides, and his customer service is closer to ASC than QSC, everything else is a bonus. Until one of the above changes, people will continue to buy from him.
zpped
Registered
Amo also 1)told us it was happening, 2) was criticized to all hell for the ISRs, 3) They aren't actually well regarded around here anymore. I put them a hair higher than nexaph, mostly because of longevity.
Jano's comment is in the testing group. If you're a member I can show you exactly where. But that is a word for word quote. He didn't say much else other than he recommended him not use it, and it can hide other impurities.
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noteablequotable
Registered
I am not in the testing group so I wasn't aware of this. I can understand why groups like that are invite only, but one of the downsides is that critical information like this doesn't circulate as far as it should. I have a lot of questions for Cain including:
1. What he was using before, and why he decided to switch to this excipient
2. What he did in response to Jano's feedback.
3. Whether or not customers received products made with this excipient, and if he's still using it.
Did he answer any of that?
zpped
Registered
Cain isn't allowed there, but I'm sure he knows it was said. It was jano telling us about it. You'd have to ask Cain, I believe he's spoken about it at some point. Personally I wrote him off as an potential option last time so I'm not seeking out his side. (he also got in trouble over at tirzhelp for another thing recently too)
The downside of not being in the deeper end is it takes longer for information to float up here. But we really do try to keep people informed. If you care about verifying stuff like that and seeing it for yourself I'm happy to help you get in.
noteablequotable
Registered
I appreciate the offer. I am ready trying to connect with someone in discord so that they can invite me to the test group, but I'll let you know if that doesn't work out.
I can tell you the answer to #3 is yes. It was at least retatrutide, possibly other peptides but the reta is all i am certain about. i know this because baba was saying he'd do some work with jano to investigate the low purity and then reship if it didnt pan out. I asked jano about this later to see what came of it, which is the discord convo @zpped referenced. Jano said it interacted with GLP1s in unusual ways and seemed like he didnt think it was a good move to go sending that to people to use. What actions baba took after this I don't know, he has been unsurprisingly silent on the matter, probably tried to sweep it under the rug along with all the other unimpressive testing his customers keep churning out.
BUT HE TAKES CREDIT CARD!!!!!! Let's keep our priorities straight here!!!!
I’ll check w the admins at the testing server to see if they’re ok w me posting screen shots of the convo
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GimmeABreak
Registered
I am part of a retest group on TG and contributed to the testing cost. There is a women running it that I think is a biologist and works in a lab that has the equipment to test much more than purity/mass. I don't completely understand all of the tests that she is running but we needed a dozen donor vials and the cost (with her discount) was $750. She is trying to identify the excipient used, if the reta will degrade faster than "normal" and if the product is safe to use. We should have results in the next week or so but given the tests I think we will need her interpratation of the results.
crossing fingers these screenshots can come out as i've got some nexa T30 in the freezer and am in a group test that's got some vials on the way to jano as we speak. i'm very curious what he has to say this go around beyond just purity/fill.
Just for clarity. His follow up test said histidine was not detected. So I'm not aware that he recognized what was in it.
@noteablequotable
Here is the discussion we talked about. I had to slice and dice it a little because there were multiple convos happening simultaneously and the relevant bit is between me and jano. Note that the guy who talks about heat resistance works with baba.
Here is the discussion we talked about. I had to slice and dice it a little because there were multiple convos happening simultaneously and the relevant bit is between me and jano. Note that the guy who talks about heat resistance works with baba.
Attachments
i messed up the redactions so had to delete and repost. your screenshots are there for ya now
I saw, much appreciated!i messed up the redactions so had to delete and repost. your screenshots are there for ya now
(And again, I was genuinely kidding. I'm also still a noob.)
we are all noobs
Yes, but I've found it's safer to preface my comments with that in case I say something stupid.
keangkong
Research Enthusiast
This looks bad. I won't be using Nexa.
