Retatrutide Fatigue/Sleepiness

iamiPAC

GLP-1 Apprentice
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I’m now fully transitioned to Retatrutide (750MCG X 4 Doses) from Tirzepatide (5MG X 1) and have noticed horrible fatigue/sleepiness. After digging deeper about this peptide I’ve come to learn that:

  • Fatigue Risk: Moderate to High. ⚠️ Many users report fatigue, especially in the early phase or when dose increases. It’s a triple agonist, and central nervous system modulation can cause sleepiness, brain fog, or low energy.
WHAT’S YOUR EXPERIENCE? 🤔
 
I've seen this in some threads and will be curious to see what people chime in with. Especially if some may weigh in with comparison regarding this subject and sema vs triz vs reta. Did you get the fatigue with triz?

I'm fairly susceptible to fatigue, like even catch a mild cold, i get smacked down with it pretty hard.

I have done a lil research with a very small dose of .5mg reta 3x per week and have observed benefits without fatigue. so that was good, but take it with a grain of salt because i'm not so sure what i have. it was sourced from research chem companies so for all i know it may have been any of the 2 others relabeled as reta. I'll be stepping up my game soon with an order from one of the providers more experienced people around have commented favorably about.
 
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I’m now fully transitioned to Retatrutide (750MCG X 4 Doses) from Tirzepatide (5MG X 1) and have noticed horrible fatigue/sleepiness. After digging deeper about this peptide I’ve come to learn that:

  • Fatigue Risk: Moderate to High. ⚠️ Many users report fatigue, especially in the early phase or when dose increases. It’s a triple agonist, and central nervous system modulation can cause sleepiness, brain fog, or low energy.
WHAT’S YOUR EXPERIENCE? 🤔
How much is your weekly total dose?
 
I've seen this in some threads and will be curious to see what people chime in with. Especially if some may weigh in with comparison regarding this subject and sema vs triz vs reta. Did you get the fatigue with triz?

I'm fairly susceptible to fatigue, like even catch a mild cold, i get smacked down with it pretty hard.

I have done a lil research with a very small dose of .5mg reta 3x per week and have observed benefits without fatigue. so that was good, but take it with a grain of salt because i'm not so sure what i have. it was sourced from research chem companies so for all i know it may have been any of the 2 others relabeled as reta. I'll be stepping up my game soon with an order from one of the providers more experienced people around have commented favorably about.
Great input friend and to answer your question, I had zero fatigue/sleepiness on Tirzepatide. I was on Tirzepatide for 3 months.
 
I have read and heard so many positive stories about Reta. I wanted to love it but the fatigue, sleepiness, and lethargy was just too much for me to handle. Like you, I experience very little fatigue/sleepiness from Tirz outside of the normal feeling of sluggishness due to major caloric reduction.

Sema - Did I lose weight, yeah. That was mainly due to the fact that I felt like I was on the verge of throwing up every single second I was awake and couldn't even look at food. Tried to tough it out for 4 weeks, the dose never went up and I never felt any better so I said "Never again!" As far as fatigue/sleepiness goes though I never really felt much on Sema.

Tirz - Up to 12.5mg per week. Feel sluggish at times but can still get done in my life what needs to be done. Steadily losing 1 to 3 pounds a week. I have never had a sweet tooth, Tirz gives me one for sure! I could eat gummy bears and drink Sprite all day and be the happiest dude on earth 🙂 Good thing I can only eat like 10 gummy bears before I feel like I am going to explode.

Reta - Started at 2mg per week then bumped it to 4mg. The most tired and fatigued that I have ever felt in my life was the first time that I had covid, Reta at 4mg was a close second. Falling a sleep at my computer desk, not taking the trash to curb to be picked up... crazy tired and lazy stuff like that. A little dizziness to go with it, almost felt slightly hypo the entire day but a little different. Blood pressure was good, blood sugar was good. It was concerning me enough that I got my blood drawn to check things out. Everything came back looking normal except estrogen was towards the low side of normal, a first for me as I am typically at the high side or normal. Quit Reta and started felling normal within 10 days.

Sema never again, but I will give a Reta another try in the future and report back. Hopefully I was taking something that wasn't Reta and I can enjoy all the benefits with the rest of you all 😉
 
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I asked the Peptide Whisperer himself, Hunter Williams with his wife Taylor, on this morning’s YouTube live, about this exact question and they suggested adding NAD+ and MOTS-C into my stack. Since I already take NAD+, I shall be adding MOTS-C into the research. Let’s hope I get my energy levels back up. If not, I might go back to Tirzepatide.



ANY THOUGHTS FRIENDS? 🤔
 
I have read and heard so many positive stories about Reta. I wanted to love it but the fatigue, sleepiness, and lethargy was just too much for me to handle. Like you, I experience very little fatigue/sleepiness from Tirz outside of the normal feeling of sluggishness due to major caloric reduction.

Sema - Did I lose weight, yeah. That was mainly due to the fact that I felt like I was on the verge of throwing up every single second I was awake and couldn't even look at food. Tried to tough it out for 4 weeks, the dose never went up and I never felt any better so I said "Never again!" As far as fatigue/sleepiness goes though I never really felt much on Sema.

Tirz - Up to 12.5mg per week. Feel sluggish at times but can still get done in my life what needs to be done. Steadily losing 1 to 3 pounds a week. I have never had a sweet tooth, Tirz gives me one for sure! I could eat gummy bears and drink Sprite all day and be the happiest dude on earth 🙂 Good thing I can only eat like 10 gummy bears before I feel like I am going to explode.

Reta - Started at 2mg per week then bumped it to 4mg. The most tired and fatigued that I have ever felt in my life was the first time that I had covid, Reta at 4mg was a close second. Falling a sleep at my computer desk, not taking the trash to curb to be picked up... crazy tired and lazy stuff like that. A little dizziness to go with it, almost felt slightly hypo the entire day but a little different. Blood pressure was good, blood sugar was good. It was concerning me enough that I got my blood drawn to check things out. Everything came back looking normal except estrogen was towards the low side of normal, a first for me as I am typically at the high side or normal. Quit Reta and started felling normal within 10 days.

Sema never again, but I will give a Reta another try in the future and report back. Hopefully I was taking something that wasn't Reta and I can enjoy all the benefits with the rest of you all 😉
Thanks for your comment. Like you I am going to try to hang in there for a full month and if it doesn’t get better after adding MOTS-C I’ll go back to Tirzepatide. See my comment about my question answered by Hunter Williams above. 👆🏼
 
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I asked the Peptide Whisperer himself, Hunter Williams with his wife Taylor, on this morning’s YouTube live, about this exact question and they suggested adding NAD+ and MOTS-C into my stack. Since I already take NAD+, I shall be adding MOTS-C into the research. Let’s hope I get my energy levels back up. If not, I might go back to Tirzepatide.



ANY THOUGHTS FRIENDS? 🤔
Mots-c did nothing for me. I tried a couple times, but with and without SS-31 first. Glutathione does more.
 
I am going to try to hang in there for a full month and if it doesn’t get better after adding MOTS-C I’ll go back to Tirzepatide.
Have you considered the tirz/survo stack? I just got my survo order. But I just changed my dosage and schedule so I can't start the research just yet.
 
The reason people feel sluggish on these drugs is because you aren’t eating. Other peps might give you a boost but it’s artificial. We really need to focus on what we are consuming and that we have a balanced diet. We are starving ourselves on purpose here to lose weight. The GLPs just make us not think about it.
 
I don’t have the fatigue in ozempic I did.
What I have is insomnia
Insomnia is hell. I’ve suffered for years and the only thing that helps me is Tizanidine. Helps me fall asleep, but not necessarily sleep long.
 
So im titrating down from 10mg tirz due to muscle loss and am currently at 1mg reta 3x weekly ( total weekly dose 3mg)
Still, eventhough redundant am at 4mg tirz and soon to be at 3mg. I did experience fatigue but NAD+ did help and even tried tesofensine which didn't sit right with me. The best thing to combat my fatigue which I no longer have was constant eating. I started trying to break my meals up into atleast 6 small.meals and as long as I had calories to burn i got rid of the fatigue. Tirz and reta are both great to me and I do see the advantages of switching to reta but I will say for me tirz helped a bunch with Inflammation
 
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