SS-31 protocols?

[Skidude]

By @GimmeABreak, an interesting experience with SS-31, with more energy than MOTS-c:

ss-31 energy is anecdotal..
However, the "feeling" is real.
But only you get it.

 

[Peloma]

ss-31 energy is anecdotal..
However, the "feeling" is real.
But only you get it.

True. I just finished my first kit of SS-31, and definitely got feels early on. They dissipated, but the positive energy was still there.

Side note: Mots-c stings as advertised.

 

[Calm Logic]

The International Peptide Society is recommending 200 mg per day???

They certainly seem to be:

SS-31 - The International Peptide Society

SS-31 Szeto-Schiller-31 Elamipretide MTP-131 Bendavia SBT-272 Mitochondrial Antioxidant Support Contents Sequence: D-Arg-Dmt-Lys-Phe-NH2 Molar Weight: 639.8 g/mol Molecular Formula: C32H49N9O5 Most Frequent Uses: Mitochondrial support Neuroinflammation Memory/cognitive support Mitochondrial...

peptidesociety.org

• SubQ dosage:
  • Supplied 100mg/ml
  • 2ml SubQ daily x 4 weeks

 

[Calm Logic]

ss-31 energy is anecdotal..
However, the "feeling" is real.
But only you get it.

And MOTS-c is banned by the World Anti-Doping Agency (WADA), unlike SS-31. So I assume that is more evidence that MOTS-c would potentially provide more of a boost than SS-31.

 

[Peloma]

The International Peptide Society is recommending 200 mg per day???

They certainly seem to be:

SS-31 - The International Peptide Society

SS-31 Szeto-Schiller-31 Elamipretide MTP-131 Bendavia SBT-272 Mitochondrial Antioxidant Support Contents Sequence: D-Arg-Dmt-Lys-Phe-NH2 Molar Weight: 639.8 g/mol Molecular Formula: C32H49N9O5 Most Frequent Uses: Mitochondrial support Neuroinflammation Memory/cognitive support Mitochondrial...

peptidesociety.org

That would get expensive real fast. The most i took in this last cycle was 10mg. I didn't feel any increased benefit, but that's how these things work. Most of the benefit is in the background.

 

[Calm Logic]

I tried to contact them (The International Peptide Society), but their online form isn't working. But I will try to contact them somehow when I get a chance to see if it is a typo.

 

[Heatheranne818]

I read that, and it kept me from my dose of selank. I did just bang 700mg of Semax. Let's see how well they play together.

So how’d it go?

 

[Peloma]

So how’d it go?

Great. I'm two shots into mots-c, and have felt synergies with the nootropics. I'm charged!

Interesting side effect of this protocol... my sex drive got turned up with SS-31. Like ready at the drop of a hat.

 

[narrow11]

My girlfriend has stage 5 chronic kidney disease and took SS-31 at a dosage of 2.5 mg daily for nearly two months, with intermittent breaks, but it had no noticeable impact on her kidney function. It is possible the dosage was too low for her to experience any effects, as most clinical protocols I have seen range between 4–10 mg, so it may be worth considering another attempt. She also has type 1 diabetes, and is currently on MOTS-c and Retatrutide at 0.5 mg weekly, which has effectively stabilized her blood sugar levels around 3–4, something she has never experienced before. I would appreciate any anecdotal input on peptides and protocols that could be beneficial for her condition, as the next stage is dialysis, which she refuses.

 

[Fisherman2356]

I feel ya. I've been on 5mg daily for 11 days. Starting Mots-c on day 14. 5mg daily with two days off (3/2). Ss-31 will probably always be part of the rotation since I have felt some energy and focus gains.

I always doubt when people say I feel some more energy, and also when they say I heal faster. Those two are very subjective. As an example, I have more energy today than I had yesterday even though I never did anything. Long story short after trying almost every peptide there is I've come to the conclusion that at best it is money down the drain, and at worst it is money down the drain plus perhaps some unwanted side effect however small that may be.

So, I'm sorry to be blunt but no, you did not have more energy, or any positive effect from SS-31. GLP1's and HGH are an exception to the rest of peptide rule - being useless. BTW, I wish peptides really worked because I bought into the hype and still have one year or more worth stashed on a medical freezer with about 20-25 most common ones, I doubt I'll ever even use. This is my experience, and I think everyone who's getting great results it is in fact getting a good dose of placebo effect.

 

[Calm Logic]

I always doubt when people say I feel some more energy, and also when they say I heal faster. Those two are very subjective. As an example, I have more energy today than I had yesterday even though I never did anything. Long story short after trying almost every peptide there is I've come to the conclusion that at best it is money down the drain, and at worst it is money down the drain plus perhaps some unwanted side effect however small that may be.

So, I'm sorry to be blunt but no, you did not have more energy, or any positive effect from SS-31. GLP1's and HGH are an exception to the rest of peptide rule - being useless. BTW, I wish peptides really worked because I bought into the hype and still have one year or more worth stashed on a medical freezer with about 20-25 most common ones, I doubt I'll ever even use. This is my experience, and I think everyone who's getting great results it is getting a good dose of placebo effect.

I like what the behavioral economist
Rory Sutherland says about placebo effects. They should be welcomed as a way to maximize the overall effect.

In the Meso/steroid world, they have the opposite problem in a way. Many of the desired feelz are definitely steroid-related but so are the lab results saying your cholesterol, hematocrit, or PSA or ALT is up or heart imaging shows pathological thickening.

So effects of peptides like SS-31 may not show up in everyday lab results but they may be a form of insurance rather than liability, including for steroid users with supraphysiological levels of testosterone.

Some peptides like glutathione should help lower elevated values like ALT, based on what I remember in studies and anecdotal reports.

There is a way to test NAD levels in the blood but then the question is how much is getting to the cells. For Epithalon, one can do telomere testing. Soon it becomes a rich man's game, but some here could routinely afford such specialized testing.

 

[Jellybelly54]

I

've been trying SS-31 for a clinically diagnosed mitochondrial disorder, linked to heterozygous PINK1 and OPA1 mutations. I've been taking large doses—15 to 30 mg per day for a week. It's hard to say if it's having a positive effect so far—maybe it would have been more effective if I'd started 15 years ago when the condition became full-blown. The goal is to upregulate mitochondrial fusion (defragmentation) via the working OPA1 copy.

I noticed that clinical trials use massive doses. Does anyone know why SS-31 is so expensive or if there's a way to get it cheaper? I probably need to buy a gram.

At this point, I'm planning to either get somewhat healthier or die trying—no joke. After a decade of promises, a Harvard-trained biomedical geneticist and mitochondrial expert told me there’s nothing in the drug pipeline—nothing panned out—so self-experimentation is my only option.

hope you are using red light therapy too! That’s a must for mitochondrial disorders . 660-940nanometer wavelength lights are so helpful. Probably more helpful than a lot of these peptides to be honest.

 

[Calm Logic]

CoQ10 is a cheap mitochondrial supplement.

 

[Jellybelly54]

The large doses are for Barth’s disease. The trials were done at 40 mg/day subq. The 40 mg dose come from the pharmaceutical dose decided on for the treatment of Barths Syndrome:
“Elamipretide, aka Ss-31 and its brand name is FORZINITY. It’s approved for use is Barth Syndome, a rare genetic disorder causing muscle weakness by targeting mitochondrial dysfunction, improving energy (ATP) production, reducing oxidative stress, and enhancing heart and muscle function in patients. This first-ever treatment for BTHS significantly improves physical activity and quality of life by stabilizing mitochondria, the cell's powerhouses, and is a major breakthrough for patients with this debilitating condition. “

The idea behind using 4 mg is just conjecture based on extrapolation from the legitimate dose used to treat a serious mitochondrial disease.

 

[Calm Logic]

My current plan for SS-31 is 5 mg once a day alternating with twice a day. Total number of days would be 13 or 14 for my 10-mg kit: