Tirz-Appetite suppression or weight loss?

[Glp1judd]

I found that if I drink a 100 calorie 20 G protein shake at night or at a waking I’m not having night time low blood sugar dips or cravings. My fav is Clean Simple Eats vanilla. It has digestive enzymes too so it’s easy on tummy for us constipation prone glp users.

Thx. I make a lot of smoothies.

 

[Galora]

Try DSIP (Delta Sleep Inducing Peptide), if you are comfortable with daily injections. It improves my sleep quality exponentially.

I'm not ready to start adding more peps yet but thanks for the suggestion! I'll definitely consider it if this get worse.

 

[Glp1judd]

My fitbit watch tracks oxygen spikes at night and it doesn't look like I have apnea. But I truly didn't do a sleep test to confirm. I'm also in BP meds, specifically a beta blocker that lowers HR so ... Mine is increased even with that. I never had carb cravings but I'm suspecting the low glucose. I also take metformin along with tirz so I might be going too low at night. I'm more and more thinking that I should go back to a CGM for a few weeks and see how it's going

If you’re waking up WIDE AWAKE 60-90 minutes after falling asleep, I’d wager you save apnea.

And you’re being jolted with epinephrine as a survival response. I dunno how much an spo2 meter will pick up since it’s so transitory.

I’m pretty sure they do at home sleep monitoring now.

If you sleep alone and don’t want to do a study, maybe set up a camera and film yourself. See if you snore. See if you see a pattern.

I slept like sh&t for YEARS. Now I’m Gooooood.

Mask didn’t help w weight like they said it would tho…. (Maybe if I wore all day, lol)

 

[meowTime]

Exactly, the TDEEs are useless to those with weight that is metabolically related.

They're not useless. No matter what your metabolic issue, there is a kcal amount per day that you will lose weight at. 900 is gonna be below that amount for the vast vast majority of people. Humans need energy to exist and that energy is either gained from food, fat, or muscle.

If I were OP and I continued not losing weight on such a low amount for another week or two, I'd look into getting my BMR measured. And if that is out of wack I would bring it to a doctor to perform more tests. If I skipped the BMR thing the doctor probably wouldn't listen to me tbh.

 

[meowTime]

Well they said the scale hadn't moved in 3 weeks, not months, so that's what I was basing it on. I'm also very sedentary and I feel dehydrated on anything less than 80oz, but that number will change when my body does. It's advised to set baseline hydration to half your body weight in ounces, however baseline is only part of the equation. For me that baseline is currently just under 100oz. If I were more active I'd definitely be needing to up that number.

Editing to add this screenshot in case anyone needs to figure out their hydration needs:
View attachment 2699

I've tried to drink my weight in lb / 2. It always leads me to being overhydrated (you're actually not supposed to pee 10 times a day and your pee is not supposed to be clear!) I would use this as a baseline but consider everyone is different and if you think you're peeing too much, you probably are and should lower your intake.

 

[Galora]

If you’re waking up WIDE AWAKE 60-90 minutes after falling asleep, I’d wager you save apnea.

And you’re being jolted with epinephrine as a survival response. I dunno how much an spo2 meter will pick up since it’s so transitory.

I’m pretty sure they do at home sleep monitoring now.

If you sleep alone and don’t want to do a study, maybe set up a camera and film yourself. See if you snore. See if you see a pattern.

I slept like sh&t for YEARS. Now I’m Gooooood.

Mask didn’t help w weight like they said it would tho…. (Maybe if I wore all day, lol)

It's usually 4-5 hours after falling asleep. I don't snore thankfully. I used to sleep great and now it's effed up.

 

[moonpies4misfits]

I've tried to drink my weight in lb / 2. It always leads me to being overhydrated (you're actually not supposed to pee 10 times a day and your pee is not supposed to be clear!) I would use this as a baseline but consider everyone is different and if you think you're peeing too much, you probably are and should lower your intake.

Anything between 4-10 times a day is considered normal. The exact number can vary from person to person and while 10x may be normal for some people, it also may be too much for other depending on how their body is processing fluids. But yeah, everyone's body is different, and there are other factors at play as well. A portion of hydration comes from our food and that can vary wildly depending on diet. I definitely don't eat much hydrating food. I sweat a lot at night (yay surgical menopause lol) so I need to replenish during the day as well. Agreed that your pee should not be completely colorless, at least not consistently.

Edit to add: If someone is used to being dehydrated and they suddenly start hydrating more, they usually pee a whole lot the first couple of weeks as the kidneys adapt, and then it tapers down. (This is what my medical team told me.) It takes some time for the body to adjust and start processing fluids more efficiently. When I first started focusing more on hydration I was peeing like crazy the first few weeks, but I went from barely drinking water to drinking a lot. I'm drinking the same amount now but now that my body had gotten used to regular hydration I'm peeing like 6-8 times a day.

 

[yelloeyes]

Wait! Don’t leave me hanging! What hormones did you go on? I need more info.

Oh boy... ready for my book? I went through menopause early and suffered for a few years without doing anything.. hot flashes, not sleeping, bitchy, gained weight... My gynecologist, who was already on hormones, would not prescribe. I found hormone/menopause specialist an hour and a half away. We ran blood work. I was absolutely depleted of my hormones... post menopausal. We started with a compounded testosterone, estrogen, progesterone and DHEA cream. I fell better DAYS later! For some reason, I stopped absorbing just the estrogen (we still cannot figure that out) about 4-5 months later and I started compounded T, E & P injections and I take 25mg DHEA nightly that I buy off Amazon. It has been phenomenal. I feel human again. The first 15 dropped immediately... then I stalled. I went on Ozempic. I only pay $15/mo. My husband has great insurance. We have had to make some tweaks with my hormones at times. I bumped my Testosterone a bit in February after doing bloodwork again. At this point I drive there 2x a year as Georgia changed their laws with prescribing testosterone. If you have any questions or need help finding someone please reach out. I will be happy to try and help. I have been doing this for about 3 years now and have done a ton of research.

My mom is 79 and has been on estrogen for years. I just recently had to find her someone who would write her prescriptions as her gynecologist passed away. Some doctors said, "I don't have anyone her age on hormones." Well, good for you. The last time I saw her and she ran out she had brain fog, night sweats and was confused. Her doctor wanted to put her on antidepressants! I found an NP who works for a wellness center that specializes in hormones. She was happy to help. I also ordered her back up pills from India just in case she ran out again.

 

[yelloeyes]

I realize now that I was constantly craving “something” my whole life, and I also have learned that food was a way I medicated that. It wasn’t hunger. I believe it’s a hormonal sugar/insulin imbalance that these drugs somehow are treating.

I think sugar is WILDLY addictive, and getting my body used to vastly reduced sugar isn’t easy. I’m not doing atkins or anything, I’m just doing protein and veggies - as much as I want - with minimal bread/starch and no sweets.

Donuts were on sale the other day. I bought a box and ate the whole thing in one day. . That messed up my tummy and also kicked in the craving for a few days.

My heart rate fluctuates, but I take Ritalin and still on a bp med, so I can’t offer any advice. (My bp meds are already reduced 2/3 after losing this weight!)

I think many/most older/overweight people have sleep issues including apnea. I’ve been wearing a mask for like 4 years and it completely changed my sleep experience. I think so many would benefit.

I just read an article that they are starting to use GLP-1 for addiction treatment as well. It makes sense.

 

[AndyPanda]

I just read an article that they are starting to use GLP-1 for addiction treatment as well. It makes sense.

It will make it even harder to get.

 

[Needsalife]

Apologies, there are so many newbies who do not do any research before starting tirz, or whatever GLP-1, and don't realize all the good habits they think they have, sometimes they do and sometimes they don't actually have them. You can easily find out how tirz works by googling it. There are tons of articles that explain how it works, and on what receptors. And it's a good rule of thumb for anyone on these meds to do that homework, so they understand what they are taking. Obviously you are a tried and tested healthy eater, as was I. You are only at 2.5 mg a week - that is the introductory/starter dose. Many are lucky and lose on it. Many do not. Many only start to lose once they hit 7.5mg or 10mg or 12.5 or 15. What has swept through places like Reddit is this notion that you have to stay on a low dose. That somehow being on a low dose is good or better, and really it's a meaningless concept. You do want to maximize each dose for yourself before increasing. I am no doctor, I can give no medical advice, can only speak to what I've learned and/or experienced for myself. How long have you been on the 2.5mg dose? If a few months, then it is time to move up, and if you only just started it, and are in your 3d week, then I'd suggest waiting another week, but in both cases, I suggest you increase your protein, increase your water, don't worry about the other macros - I don't think ketosis or IMF or anything like those diets are helpful on this med, my personal opinion - and see how you do deliberately increasing those for the next week. Give yourself some time for your body to catch up with how the med works - your hormonal imbalances, your PCOS makes it work more slowly, it's just a fact - and time for your body to adjust to the new and improved plan, yes, it's only a tweaking of the course you've followed for years, but the difference between 100 grams of protein and 130 or more per day is actually quite amazing. Same too with the hydration. In either case, whether you've been on 2.5mg for only 3 weeks, or for more than a month, do the new and improved for another week, and if there is no change in terms of weight loss, then increase your dose. And if you're on compound, then you don't have to increase up to 5mg per the standardized, you can increase in smaller increments. You've been lucky, on 2.5mg with no side effects, and great appetite suppression, no food noise, etc. - it would be wonderful if you can keep those effects, and not experience the gastro and other side effects, so titrating up slowly is always a good idea.

Thank you! Good info here. I’m actually 8 weeks in and on 5 mg. 4 weeks at 2.5 mg and 4 weeks at 5 mg. So I’m at the point of deciding whether to go up or not. I am going to experiment with water. Increasing protein more is going to take some research, especially without increasing calories. But I’ll try to find a balance. I appreciate you taking the time to help me figure it out.

 

[Needsalife]

Have you looked into trying a cycle of 5-Amino-1MQ, or MOTS-C?

This. This is the kind of info I need. What you say is Greek right now but it gives me something to research. Thank you!

 

[Needsalife]

I’m at 10 now. First week. Honestly I went up because I bought a kit of tirz 40 and the math was easier.

Last year I did the compound route. Lost 40lbs April- December. Started at 2.5 peaked at 7.5.

Then financial realities kicked in and I couldn’t swing the costs. So I went off. Gained back 20-25 by April and that when I started research both intellectually and physically.

Was on 5, then 7.5 and just went up to 10. I don’t sense a difference. I’m still hungry much of the time. When I am I eat grilled or roasted chicken. Or eggs. Yesterday I ate a whole rotisserie chicken at lunch. I was hungry! I cannot have sweets or junk food in the house - I will devour it. I don’t drink soda.

Now that my knees don’t hurt with every step i bought a garmin watch. My activity level is very low, like 2500 steps. So I’m gotta try to up that slowly.

That’s all I’m doing so far. Just had to buy new jeans, other ones were falling off. The difference is noticeable, but still like to lose 50 more. I think it will happen within the next year.

I have plenty of tirz now, thanks to other researchers pointing the way.

Thanks for sharing. That’s wild to me that you haven’t experienced the appetite/food noise suppression. We are all so different. I’m glad you’ve been able to get back on. Good luck!

 

[Glp1judd]

Thanks for sharing. That’s wild to me that you haven’t experienced the appetite/food noise suppression. We are all so different. I’m glad you’ve been able to get back on. Good luck!

I’m not sure exactly what that means honestly. I’m eating less, but still a lot ( I’m a 320lb 6 foot 4 man I need food!).

But I’m not constantly grazing like I used to. And the idea of greasy or heavy food is nauseating, so that’s new…

 

[MingHenry]

Thank you! Good info here. I’m actually 8 weeks in and on 5 mg. 4 weeks at 2.5 mg and 4 weeks at 5 mg. So I’m at the point of deciding whether to go up or not. I am going to experiment with water. Increasing protein more is going to take some research, especially without increasing calories. But I’ll try to find a balance. I appreciate you taking the time to help me figure it out.

My pleasure! Actually, you might need to eat more, temporarily. Sometimes stalls can be broken, counter-intuitively, by eating more! Your body may be holding onto the lbs because it's aware calories have been taken away and it doesn't like that. Up your hydration and try a couple of days of going over 1000 calories with protein. If you get some collagen peptides - I like Vital Protein and Revive Naturals and Live Conscious - and add whatever the suggested serving size is to your morning coffee(s), that's protein right there. My morning coffee has become my mushroom coffee (I don't drink regular coffee), collagen peptides, both unflavored and sometimes chocolate, and I use a bottle of Fairlife protein shake. If you add in a protein shake in the afternoon, that's more protein. Same with the Oikos Pro, a lot of protein in a small enough helping and I usually eat that late at night. I'm not and never have been a breakfast eater. I've never been a person who eats three meals a day. In the morning, first I drink down all 67 ounces of water with LMNT. Then I have my coffee, but now my morning coffee works for me - filled with protein. I had two coffees this morning, totaling 335 calories and 59.9 grams of protein. I used 1/2 of total serving of Vital Proteins Chocolate Collagen Peptides in each coffee, and split the serving of VP's Advanced collagen Peptides over the two coffees, and used one Fairlife chocolate shake in both. No one @me - I don't like breakfast. So I have found a way that works for me in the mornings without force feeding myself food that I don't want. Most afternoons I have a protein shake with lots of things in it. I also have kitchen basics chicken bone broth - 45 calories a container and 10 grams of protein, started having it before I had major surgery and have kept on using it. I use lots of eggs, cottage cheese, all the usuals for high protein. For me, I wasn't going to suddenly become a 3 meal a day eater, or a meat-eater, but adding all that protein to my coffee each morning gets me off to the right start.

 

[DwightTheDelight]

I’m not sure exactly what that means honestly. I’m eating less, but still a lot ( I’m a 320lb 6 foot 4 man I need food!).

But I’m not constantly grazing like I used to. And the idea of greasy or heavy food is nauseating, so that’s new…

I'm also a big dude, same height and started above 450, the appetite suppression from tirz during the first few months was incredible and i rolled with it. It allowed me to drop 100 in the first 3 months alone. In my case, I had a year's worth of food stored in my body ready to be used and this medicine allowed me to finally follow through with that. I'm now down in the 200's and searching for something to help me get back to what I felt during the early days of tirz, because it's not hitting the same anymore

 

[Needsalife]

I’m not sure exactly what that means honestly. I’m eating less, but still a lot ( I’m a 320lb 6 foot 4 man I need food!).

But I’m not constantly grazing like I used to. And the idea of greasy or heavy food is nauseating, so that’s new…

It’s unbelievable, actually. I could literally eat nothing and would be fine. I feel no hunger. Everyone needs fuel and nutrients. For me, even at 2.5 mg I didn’t care about food for the first time in my life. Very strange. I wish that was the secret to losing weight for me.

 

[Needsalife]

Oh boy... ready for my book? I went through menopause early and suffered for a few years without doing anything.. hot flashes, not sleeping, bitchy, gained weight... My gynecologist, who was already on hormones, would not prescribe. I found hormone/menopause specialist an hour and a half away. We ran blood work. I was absolutely depleted of my hormones... post menopausal. We started with a compounded testosterone, estrogen, progesterone and DHEA cream. I fell better DAYS later! For some reason, I stopped absorbing just the estrogen (we still cannot figure that out) about 4-5 months later and I started compounded T, E & P injections and I take 25mg DHEA nightly that I buy off Amazon. It has been phenomenal. I feel human again. The first 15 dropped immediately... then I stalled. I went on Ozempic. I only pay $15/mo. My husband has great insurance. We have had to make some tweaks with my hormones at times. I bumped my Testosterone a bit in February after doing bloodwork again. At this point I drive there 2x a year as Georgia changed their laws with prescribing testosterone. If you have any questions or need help finding someone please reach out. I will be happy to try and help. I have been doing this for about 3 years now and have done a ton of research.

My mom is 79 and has been on estrogen for years. I just recently had to find her someone who would write her prescriptions as her gynecologist passed away. Some doctors said, "I don't have anyone her age on hormones." Well, good for you. The last time I saw her and she ran out she had brain fog, night sweats and was confused. Her doctor wanted to put her on antidepressants! I found an NP who works for a wellness center that specializes in hormones. She was happy to help. I also ordered her back up pills from India just in case she ran out again.

Thank you. That’s an amazing story, especially your mother too. My problems didn’t start at menopause and everyone has breast cancer in my family so I can’t go on hormone therapy. I’m finding that everyone has a different story, different problems. The fact that these meds help as many people as they do is amazing.

 

[MingHenry]

I'm also a big dude, same height and started above 450, the appetite suppression from tirz during the first few months was incredible and i rolled with it. It allowed me to drop 100 in the first 3 months alone. In my case, I had a year's worth of food stored in my body ready to be used and this medicine allowed me to finally follow through with that. I'm now down in the 200's and searching for something to help me get back to what I felt during the early days of tirz, because it's not hitting the same anymore

Congrats on dropping 100 lbs in 3 months!?! Amazing. Perhaps it's time to increase your dose? There are many options to look into if you've maxed out in the dosage of tirz. Lots of researching for you to do.

 

[Glp1judd]

I'm also a big dude, same height and started above 450, the appetite suppression from tirz during the first few months was incredible and i rolled with it. It allowed me to drop 100 in the first 3 months alone. In my case, I had a year's worth of food stored in my body ready to be used and this medicine allowed me to finally follow through with that. I'm now down in the 200's and searching for something to help me get back to what I felt during the early days of tirz, because it's not hitting the same anymore

Wow. That’s an incredible amount of change for your body to acclimate to. I have zero first hand experience that would be applicable.

I’m looking at all this as a lifelong supplement that changes my relationship with food and most importantly sugar.

Whatever “noise suppression “ I’m getting has been enough to get into a calorie deficit with zero other behavior changes. That’s huge for me.

But my loss has been very slow relative to what you’re describing, and for me, that’s the right thing. This is a lifetime thing. Not a diet and not some kind of situation where I want to simply not eat. That’s not healthy either!

If I’m in stasis or a small deficit and I’m losing a few pounds a month while also building up a little more strength, that’s a win!

While that’s happening I’m learning better ways to eat (including smaller portions because I just can’t eat big ones anymore) and maybe doing some more activity because my joints can do it now.

That’s the kind of thing I can do for a lifetime!