Thank you! Good info here. I’m actually 8 weeks in and on 5 mg. 4 weeks at 2.5 mg and 4 weeks at 5 mg. So I’m at the point of deciding whether to go up or not. I am going to experiment with water. Increasing protein more is going to take some research, especially without increasing calories. But I’ll try to find a balance. I appreciate you taking the time to help me figure it out.
This. This is the kind of info I need. What you say is Greek right now but it gives me something to research. Thank you!
Thanks for sharing. That’s wild to me that you haven’t experienced the appetite/food noise suppression. We are all so different. I’m glad you’ve been able to get back on. Good luck!
I’m not sure exactly what that means honestly. I’m eating less, but still a lot ( I’m a 320lb 6 foot 4 man I need food!).
My pleasure! Actually, you might need to eat more, temporarily. Sometimes stalls can be broken, counter-intuitively, by eating more! Your body may be holding onto the lbs because it's aware calories have been taken away and it doesn't like that. Up your hydration and try a couple of days of going over 1000 calories with protein. If you get some collagen peptides - I like Vital Protein and Revive Naturals and Live Conscious - and add whatever the suggested serving size is to your morning coffee(s), that's protein right there. My morning coffee has become my mushroom coffee (I don't drink regular coffee), collagen peptides, both unflavored and sometimes chocolate, and I use a bottle of Fairlife protein shake. If you add in a protein shake in the afternoon, that's more protein. Same with the Oikos Pro, a lot of protein in a small enough helping and I usually eat that late at night. I'm not and never have been a breakfast eater. I've never been a person who eats three meals a day. In the morning, first I drink down all 67 ounces of water with LMNT. Then I have my coffee, but now my morning coffee works for me - filled with protein. I had two coffees this morning, totaling 335 calories and 59.9 grams of protein. I used 1/2 of total serving of Vital Proteins Chocolate Collagen Peptides in each coffee, and split the serving of VP's Advanced collagen Peptides over the two coffees, and used one Fairlife chocolate shake in both. No one @me - I don't like breakfast. So I have found a way that works for me in the mornings without force feeding myself food that I don't want. Most afternoons I have a protein shake with lots of things in it. I also have kitchen basics chicken bone broth - 45 calories a container and 10 grams of protein, started having it before I had major surgery and have kept on using it. I use lots of eggs, cottage cheese, all the usuals for high protein. For me, I wasn't going to suddenly become a 3 meal a day eater, or a meat-eater, but adding all that protein to my coffee each morning gets me off to the right start.
I'm also a big dude, same height and started above 450, the appetite suppression from tirz during the first few months was incredible and i rolled with it. It allowed me to drop 100 in the first 3 months alone. In my case, I had a year's worth of food stored in my body ready to be used and this medicine allowed me to finally follow through with that. I'm now down in the 200's and searching for something to help me get back to what I felt during the early days of tirz, because it's not hitting the same anymore
It’s unbelievable, actually. I could literally eat nothing and would be fine. I feel no hunger. Everyone needs fuel and nutrients. For me, even at 2.5 mg I didn’t care about food for the first time in my life. Very strange. I wish that was the secret to losing weight for me.
Thank you. That’s an amazing story, especially your mother too. My problems didn’t start at menopause and everyone has breast cancer in my family so I can’t go on hormone therapy. I’m finding that everyone has a different story, different problems. The fact that these meds help as many people as they do is amazing.
Congrats on dropping 100 lbs in 3 months!?! Amazing. Perhaps it's time to increase your dose? There are many options to look into if you've maxed out in the dosage of tirz. Lots of researching for you to do.
Wow. That’s an incredible amount of change for your body to acclimate to. I have zero first hand experience that would be applicable.
It's definitely more than just an appetite suppressant. The studies have been pretty clear that it ups metabolism (whatever that means) and causes the body to get rid of fat cells. For pure appetite suppression semaglutide is king (maybe cagrilintide?). But tirz has some special sauce where you can still eat and lose weight. Retatrutide has even more of that special sauce. 5mg isn't really a thereaputic dose according to Eli Lilly. If you're not losing on 5mg, it's time to move up, and keep moving up on schedule as long as you aren't suffering wih side effects. 15mg is the current thereaputic max and Eli Lilly is currently studying the safety of doses up to 25mg.
Love it, man! Keep it up
I am partly disabled and sedentary and I've lost 55lbs in 6 months with tirz. I am new to this forum and so glad to see that there are so many experts!
I just read one of your replies. Of the 900 calories are you getting enough protein? I did Macros for a while and it really helped. I was eating too many carbs and not getting enough protein. I promise I will stay in my lane about your calorie intake.
It sounds like your question is: “Because my diet and exercise are pretty much the same as before Tirz, and I was already in a calorie deficit and don’t need help with food noise and appetite, I’m hoping Tirz is a peptide that will function to burn fat off my body. Is that the case?”
That is actually too much. You can talk to a urologist to confirm (I got this info from one) but you are likely drinking too much.
Yeah, a lot of changes and a lot of growth and some mourning and grief are all accompanying this phase.
Considering my own experience, it's crazy to me that 5mg isn't considered a therapeutic dose and that they are considering moving all the way up to 25mg but as long as it works for people that's all that really matters. I think when I get to the point that the medicine is increasingly not working, I will take a break for a month or two to try and reset like some here have done.
Hey another member of the constantly having to pee club. Not sure about you but it's been this way my whole life. The worst is long drives.
Nah. It’s not too much, I’ve been like this my entire adult life. My pee always has color and I don’t drink anywhere as much as “they” say I should.
Some of us just have tiny bladders! 😅
The wiki on it mentions something about it being less stable in vitro. Is that at all an issue?
I just started DSIP (and will be starting Epithalon and VIP). I saw you linked to that dosing chart - what protocol and dosing are you following? I've researched all the protocols I could find - and still trying to decide which one "feels" right to me. I'm only 4 days in and still finding the right time for the dose -went from 9pm to 11:30 pm, yesterday was 6pm, today was 5pm - and staying at 100mcg which I feel until I figure out the correct timing for my body. I'm dealing with serious and chronic insomnia and circadian rhythm disruption.
Chill buddy, assume best intent. I didn't read her question as being contrary or having attitude.
Definitely worth looking into, but there are many peptides that have a range of possible benefits that include weight loss, metabolism and more. FWIW, 2 months on tirz is not a long time. People are skipping among GLPs like they are candy, switching and adding and stacking too much and too soon and often not giving the initial GLP they are on time to work, and switching and stacking without much knowledge about what interacts well and what doesn't. Some people don't respond well to one or the other or the other GLPs. A seemingly small number are non-responders. But oddly you are responding because of your lack of appetite and food noise etc. Whatever you do, remember that only tirz and sema have actually been FDA approved and have gone through all the testing. Reta, Cagri in conjunction with others, mazo, etc, are all still in the testing phases and there is research to read, protocols the tests are following to learn about. Just a suggestion to dig in and learn before jumping in and injecting into your body. Having patience and going slowly is a good thing. The motto I can't take credit for but follow is to avoid known or discoverable risks, reduce the chances of harm to myself, and always start low and slow.
That's not the protocol I'm following though measuring dose against body weight is interesting. Is this your first research with it? It's mine I've started at 100mcg and trying to find the right time to dose that works with my body. 9 pm and 11:30 pm weren't right for me. 6 pm was better yesterday and today was 5 pm. For severe and chronic insomnia and circadian rhythm issues, like I have, I have read that higher doses for longer periods may be most effective, but figured I would start off low and feel my way from there. I do feel a tiny bit groggy in the morning from only 100mcg but it passes quickly. Any morning grogginess for you? When you say 4 week flush, do you mean you cycle off it for 4 weeks and then start again? I've not seen the term "flush" used in this context.
Only groggy if I take it late or if something disrupts my sleep. Yes, 4 weeks off.
Hello. You might want to consider focusing on strengthening your gut biome for a month before increasing the GPP1 dose. Look into getting water and/or milk kefir grains to make water kefir or milk kefir at home, as well as consuming other top probiotic food sources. Also, I didn’t read the whole thread, so you may have addressed this already, consider focusing on building lean muscle mass through resistance or weight training.
I am sorry but your "research" is wrong.
This is really interesting. Thank you for sharing this... going to do some research as I never heard of this. Did the hydroxyzine not work for you?
I'm sorry, but this just isn't sound science. There's growing (but not universal) scientific consensus around the constrained energy model of energy expenditure (though even the best studies with doubly labeled water, etc. have some flaws in them), but none of these state that TDEE is useless. At most they mean that the efficiency is not 1:1, and the efficiency rate gets lower the more you push yourself. If you burn 1000 calories exercising, your body might try and save 500 calories throughout the rest of the day vs. your usual expenditure by lowering energy usage in other ways.
