WARNING - RECENT QSC PURITY FAILS

[dionysos]

RECENT QSC PEPTIDE BATCH COAs SHOW LOW PURITY LEVELS​

While it is not yet known if these product batches are dangerous,
they certainly indicate poor control of the manufacturing process, and
a lack of due care in presenting them for purchase.

United States Pharmacopeia (USP) and National Formulary (NF) standards
both require pharmaceutical grade products to be at least 99 percent pure.

PLEASE CHECK PURITY OF YOUR QSC PURCHASES VS THIS LIST OF COAs

Quingdao Sigma Chemical Batch COAs by Janoshik
QSC: Retatrutide 15mg; black Cap; Quantity: 14.63 mg; Purity: 96.099% - Test Date 4/8/2024
QSC: Retatrutide 15mg; black cap; Quantity 14.35; Purity: 98.317% - 5/4/2024
QSC: Mazdutide 10 mg; yellow cap; Quantity 10.76; Purity: 97.772% - Test Date Unknown
QSC: Tesamorelin 10 mg; clear cap, blue crimp; Quantity 11.41; Purity: 94.644 % - Test Date Unknown
QSC: Survodutide 10mg; clear tan or maybe clear gray??; Quantity: 11.19 mg; Purity: 97.946% - Test Date Unknown
QSC: Semaglutide 5 mg; transparent red cap; Quantity: 6.34 mg; Purity: 97.749% - 5/??/2024
QSC: Retatrutide 15mg; black Cap; Quantity: 14.63 mg; Purity: 96.099% - Test Date Unknown

 

[milos]

we have to watch other vendors too, as it seams many vendors testing with similar results right now

 

[urSinsn2me]

we have to watch other vendors too, as it seams many vendors testing with similar results right now

Can you add those vendors you're speaking about?

 

[milos]

Can you add those vendors you're speaking about?

@dionysos has compiled spreadsheets with the most discussed vendors in his signature, for more complete list you can join peppys discord

 

[Chizikitide-1977]

Have there been any recent tests for their MOTS-C?

 

[milos]

Have there been any recent tests for their MOTS-C?

I suggest you join peppys, as we are not allowed reposting the results, we can only generally talk about them here

 

[foobar]

United States Pharmacopeia (USP) and National Formulary (NF) standards
both require pharmaceutical grade products to be at least 99 percent pure.

I thought it was 95%?

 

[Mounjamen]

Hello, what is MOTS-C?

 

[dionysos]

I thought it was 95%?

No, 95% is the minimum grade acceptable for reagent grade chemicals for laboratory use per the American Chemical Society.

If you are injecting lab chemicals rather than drugs then carry on.

I'm injecting therapeutic drugs, and, the three standards groups that are relevant all agree that "pharmaceutical grade" is 99.0% purity or above @foobar

 

[Chizikitide-1977]

Hello, what is MOTS-C?

It's a naturally occurring peptide that energizes mitochondria. For some people it has been helpful in boosting the metabolism thus helping with weight loss. But unlike the GLPs, evidence for this is anecdotal for now as it hasn't been studied as extensively.

 

[foobar]

No, 95% is the minimum grade acceptable for reagent grade chemicals for laboratory use per the American Chemical Society.

ACS grade is >= 95% and "is acceptable for food, drug, or medicinal use".

I've always heard USP grade is the same as ACS grade.

If you are injecting lab chemicals rather than drugs then carry on.

No need for attitude.

I'm injecting therapeutic drugs, and, the three standards groups that are relevant all agree that "pharmaceutical grade" is 99.0% purity or above

Got a source for the 99% claim?

EDIT:

This is what chatgpt says:

The United States Pharmacopeia (USP) sets standards for the quality, purity, strength, and consistency of drugs, food ingredients, and dietary supplements. For a substance to be classified as USP pharmaceutical grade, it must meet stringent requirements for purity and quality, which are defined in the USP–National Formulary (USP-NF).
While specific purity requirements can vary depending on the substance, generally, USP grade substances must meet the following criteria:

1. Identity: The substance must be correctly identified as the specific compound it is purported to be.
2. Strength: The substance must meet the labeled potency and strength.
3. Quality: The substance must meet standards for physical and chemical properties.
4. Purity: The substance must be free from harmful contaminants and impurities.
5. Packaging and Storage: The substance must be packaged and stored in a way that ensures its quality and integrity.

For most pharmaceutical ingredients, USP standards require a purity of 95% or higher, with some substances requiring even higher purity levels depending on their intended use and route of administration. Specific details for each substance are available in the USP–NF monographs.

 

[dionysos]

ACS grade is >= 95% and "is acceptable for food, drug, or medicinal use".

I've always heard USP grade is the same as ACS grade.



No need for attitude.



Got a source for the 99% claim?

Do you have a reason for advocating a lower standard?

And there is no attitude being given. If you prefer lower purity products then have them, I'm indifferent. If on the other hand you are advocating for lower quality standards then I think that is irresponsible and you should stop.

 

[foobar]

Do you have a reason for advocating a lower standard?

Because I want to know what the truth is, and everything I'm finding says it's 95%. Unless you can come up with a credible source that says it's actually 99%, I can only go with what the data in front of me says.

 

[foobar]

I figured out how to ask chatgpt to get a better answer. Most injectable drugs are required to have 99%, but not all:

USP grade injectable drugs generally need to meet very high purity standards, and in most cases, this means a purity of 99% or higher. However, the specific purity requirement can vary based on the drug and its USP monograph.
For injectable drugs, the USP monograph will specify the acceptable range for purity. While many injectable drugs are required to have purity levels at or above 99%, some may have slightly lower thresholds depending on their intended use and the particular quality specifications outlined in their monograph.

 

[milos]

Isn't it this was discussed already?
while 95% is theoretically accepted for some drug, with peptides, majority of us are looking for >99% purity. According to Peppys cutoff for "pass" is 98%. But whatever official standards are, we are looking for the highest purity possible.
You see its like with a wine, while cheap can be drinkable, the expensive one will always taste much better - which one you prefer? Its the same with peptides ... If you go for the cheap. not so pure, OK good for you, maybe you save a few $ but 1) risking injection site reactions and 2) encouraging vendors to not care so much about quality of their products

So, I would say the 99% is the number majority of this forum members are looking for
@dionysos maybe we should make a survey to ask members of this forum which purity level they are looking for, so we have some "evidence"
let peple choose >99% >98% >95% >90%

 

[dionysos]

So, I would say the 99% is the number majority of this forum members are looking for
@dionysos maybe we should make a survey to ask members of this forum which purity level they are looking for, so we have some "evidence"
let peple choose >99% >98% >95% >90%

With respect @milos such a survey/poll would yield "opinion" rather than evidence.

In my case it would be an unjustified opinion; I suspect that would be true for the overwhelming majority of members here.

I myself am quite content to accept and to recommend the justified statements of the national standard-setting organizations who are chartered to study and pronounce on drug purity and quality.

Those that accept lower quality standards are certainly free to do so.

 

[milos]

With respect @milos such a survey/poll would yield "opinion" rather than evidence.

yes, but it could be interesting to know majority consensus, or at least their opinion what is acceptable for them

I myself am quite content to accept and to recommend the justified statements of the national standard-setting organizations who are chartered to study and pronounce on drug purity and quality.

Yes, but in addition, I like your previous statement about pushing vendors to keep the quality high

Those that accept lower quality standards are certainly free to do so.

exactly, just take the low quality product and no need to argument here that "it's just fine"

 

[Deleted member 1393]

Does anyone have info or know the QSC had brown caps for a 15 Tz and if I was good ?
I purchased two vials from a detash group

 

[MTgrizz]

Does anyone have info or know the QSC had brown caps for a 15 Tz and if I was good ?
I purchased two vials from a detash group

Whats a detash group?

 

[MiniatureSnail]

Whats a detash group?

They prob. meant destash - destashing is when you're getting rid of something you have too much of. Can be applied to anything.

 

[Deleted member 1393]

So does anyone know about the brown caps ?

 

[FourthQuintile]

Does anyone have info or know the QSC had brown caps for a 15 Tz and if I was good ?
I purchased two vials from a detash group

I'm going back through price lists and the QSC thread on Meso. Their most recent 15mg Tirz batch had these translucent yellow tops, as seen here in this Jano report:

Janoshik Analytical

Prior to that appears to be a batch of pink colored tops, as seen here in this Jano report:

Janoshik Analytical

Prior to that is some different batch, with this Jano report, report dating 1 August 2023. It doesn't indicate a cap color:

Janoshik Analytical

I can't find a mention of the cap color of what this was in the Meso thread. It does not appear that they made any batches of 15mg prior to that one.


The only brown top QSC product I'm aware of is a batch of MOTS-C from within the last year, and the Meso thread appears to mention a HGH batch from 2022. That said...these would both be very different from Tirzepatide in terms of effects. I'm not aware of what other vendors may have done for cap colors for 15mg Tirzepatide so I can't help there.

 

[FourthQuintile]

RECENT QSC PEPTIDE BATCH COAs SHOW LOW PURITY LEVELSView attachment 958​

While it is not yet known if these product batches are dangerous,
they certainly indicate poor control of the manufacturing process, and
a lack of due care in presenting them for purchase.

United States Pharmacopeia (USP) and National Formulary (NF) standards
both require pharmaceutical grade products to be at least 99 percent pure.

PLEASE CHECK PURITY OF YOUR QSC PURCHASES VS THIS LIST OF COAs

Quingdao Sigma Chemical Batch COAs by Janoshik
QSC: Retatrutide 15mg; black Cap; Quantity: 14.63 mg; Purity: 96.099% - Test Date 4/8/2024
QSC: Retatrutide 15mg; black cap; Quantity 14.35; Purity: 98.317% - 5/4/2024
QSC: Mazdutide 10 mg; yellow cap; Quantity 10.76; Purity: 97.772% - Test Date Unknown
QSC: Tesamorelin 10 mg; clear cap, blue crimp; Quantity 11.41; Purity: 94.644 % - Test Date Unknown
QSC: Survodutide 10mg; clear tan or maybe clear gray??; Quantity: 11.19 mg; Purity: 97.946% - Test Date Unknown
QSC: Semaglutide 5 mg; transparent red cap; Quantity: 6.34 mg; Purity: 97.749% - 5/??/2024
QSC: Retatrutide 15mg; black Cap; Quantity: 14.63 mg; Purity: 96.099% - Test Date Unknown

Is it possible for you to link as many of these reports as you can? I would like to see the Janoshik reports for these, but I can't find them. "Test date unknown" is unusual to me: all Janoshik reports I've seen clearly indicate the Testing Order date, Sample Received date, and Analysis conducted date. For 15mg Black Top Retatrutide, I can only find two Janoshik reports, neither of which match what you mention here:

QSC initial test November 2023, 15.39mg, 99.233% purity:

Janoshik Analytical

Blind test by Meso member posted to Meso April 2024 (I have linked directly to Janoshik report here), 14.51 mg, 98.505% purity:

Janoshik Analytical

 

[milos]

Is it possible for you to link as many of these reports as you can? I would like to see the Janoshik reports for these, but I can't find them. "Test date unknown" is unusual to me: all Janoshik reports I've seen clearly indicate the Testing Order date, Sample Received date, and Analysis conducted date. For 15mg Black Top Retatrutide, I can only find two Janoshik reports, neither of which match what you mention here:

QSC initial test November 2023, 15.39mg, 99.233% purity:

Janoshik Analytical

these "bad results" were originally linked even in their official price list (dont know if they are still there, I didn't check) and it was also posted on peppys in the latest batch of released results from a testing group, go to peppys look for 3rd party test results...

 

[FourthQuintile]

these "bad results" were originally linked even in their official price list (dont know if they are still there, I didn't check) and it was also posted on peppys in the latest batch of released results from a testing group, go to peppys look for 3rd party test results...

I went through almost a year of QSC price lists today, as evidenced in the previous post, and other than the 10mg Tesamorelin (which they've honestly never put up great numbers on) and the 5mg Semaglutide, I was unable to find anything close to what was mentioned. I mostly focused on the Retatrutide for simplicity.

 

[Deeubee]

I thought it was 95%?

Careful now. Gonna call you a pimp troll 😂.
Anyway. I believe the point has been made by all parties.

 

[Deleted member 1393]

I'm going back through price lists and the QSC thread on Meso. Their most recent 15mg Tirz batch had these translucent yellow tops, as seen here in this Jano report:

Janoshik Analytical

Prior to that appears to be a batch of pink colored tops, as seen here in this Jano report:

Janoshik Analytical

Prior to that is some different batch, with this Jano report, report dating 1 August 2023. It doesn't indicate a cap color:

Janoshik Analytical

I can't find a mention of the cap color of what this was in the Meso thread. It does not appear that they made any batches of 15mg prior to that one.


The only brown top QSC product I'm aware of is a batch of MOTS-C from within the last year, and the Meso thread appears to mention a HGH batch from 2022. That said...these would both be very different from Tirzepatide in terms of effects. I'm not aware of what other vendors may have done for cap colors for 15mg Tirzepatide so I can't help there.

Thank you so much for taking the time to search that and your response it's very appreciated. I don't know why I didn't think to look through reports 🤦🏻‍♀️.
I wonder if it's even QSC. Oh well.

 

[milos]

I went through almost a year of QSC price lists today, as evidenced in the previous post, and other than the 10mg Tesamorelin (which they've honestly never put up great numbers on) and the 5mg Semaglutide, I was unable to find anything close to what was mentioned. I mostly focused on the Retatrutide for simplicity.

you are right, I just checked, their result listed in their own price list for Tirz15 is here: https://janoshik.com/tests/41456-Tirzepatide_15_mg_JV7LYKVS8B8A but that's a test from the old batch from April, don't remember if they post before a new test for Tirz already (now its not there), the low purity issue is just from the most recent round of testing, for example:

5/??/2024 – QSC: Semaglutide 5 mg; transparent red cap; Quantity: 6.34 mg; Purity: 97.749%; by Janoshik Analytical
-4/8/2024 – QSC: Retatrutide 15mg; black Cap; Quantity: 14.63 mg; Purity: 96.099%; by Janoshik Analytical
+ few more other products tested bad, but again you have to go to peppys and discord to find all these new results, we are not allowed to re-posting from these sites.
You have to also understand, that if almost every other product from the same time period tests bad, we can assume that other products without published tests from the same batch will be similar
We all will be watching for all those new tests...
Anyway, in the meantime Tracy seems to acknowledged the issue already, but outcome yet to be seen. However, QSC has a strong track record, im sure they will get back on track fast. Its not the first time they had a bad batch - it happen to every vendor sometimes.

 

[HB_22]

Sorry for asking but I am trying to understand this. Is there a supposedly dangerous contamination in all of these peptides that tested below 99%?

 

[milos]

Sorry for asking but I am trying to understand this. Is there a supposedly dangerous contamination in all of these peptides that tested below 99%?

simple answer: no, it does not indicate "dangerous contamination"