What dose of reta are you at?

Jumped from 7.5mg of Tirz to 2mg twice weekly of Reta. Running this for 3 weeks now and appetite suppression is good with no sides so will stay at this dose as long as I can. I like the the concept of minimum effective dose and running it as long as possible.
 
Starting my transition since the last week from January
Titrating up Reta slowly but even with this small dose (now 0.35mg every two days) I'm already "feeling"
Tirz was working.. But I started to feel very fatigue and depressed.. Now I'm better
 
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I titrated aggressively from 1 to 6 mg in about a month's time. Been at 5 mg since late last year, after experiencing meat aversion at 6 mg. Just increased to 6 mg last week and only have minor altered skin sensations —otherwise no other side effects. I started Reta before the holidays last year and observed a steady decline beginning in December. Gone from 317 lbs to 276 as of last week.
 
ronin365 said:
I titrated aggressively from 1 to 6 mg in about a month's time. Been at 5 mg since late last year, after experiencing meat aversion at 6 mg. Just increased to 6 mg last week and only have minor altered skin sensations —otherwise no other side effects. I started Reta before the holidays last year and observed a steady decline beginning in December. Gone from 317 lbs to 276 as of last week.
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Can I ask if you monitor your heart rate?
 
Lyophilized said:
Can I ask if you monitor your heart rate?
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I do. I copied my post from earlier this month, I thought I was going to level off at 7mg/week but continued moving up. I'm at 9mg taken in the last week, I figure I'm going to be somewhere between 8-10mg/week leveling off (time will tell).

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woundcarping said:
I’m leveling off at 7mg/week after starting my bridge from Tirz on 1/10.
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390120 said:
I know everyone is different but I read a lot of posts where people start at low doses and don't need to titrate up that high of a dose.
I'm curious as to if people go all the way up to 12mg like in the clinical trials, if if they have reaped most benefits at lower doses.

So my question is:
How long have you been taking Reta for?
Where along are you in your journey?
What is your current dosage?
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I'm on Reta 2mg every 3.5 days to minimize sides, then intend to get to dose the whole 4mg every 5-6 days. I previously lost 20 lbs on Tirz, switched to Reta slowly about 8 weeks ago, titrated up .5 a week. I've lost a few lbs in those few weeks. My plan is to stay at 4mg for the next few weeks and see where I am at before I make further adjustments.
 
Why do people do 'lowest effective dose'? Why not just try to hit the 12mg max asap if that is what the trials show work? Is it to minimize side effects or to save money? Seems the cost savings are minimal with a lower dose.
 
390120 said:
I know everyone is different but I read a lot of posts where people start at low doses and don't need to titrate up that high of a dose.
I'm curious as to if people go all the way up to 12mg like in the clinical trials, if if they have reaped most benefits at lower doses.

So my question is:
How long have you been taking Reta for?
Where along are you in your journey?
What is your current dosage?
Click to expand...
I started on 2 mg/ weekly and titrated up after two weeks to 4 mg/ weekly and will be at 4 mg for awhile. I started at 246 and after 5 weeks I'm at 228. Amazing. I am experiencing skin sensitivity which is irritating but other than that Im doing terrific.
 
headward said:
Why do people do 'lowest effective dose'? Why not just try to hit the 12mg max asap if that is what the trials show work? Is it to minimize side effects or to save money? Seems the cost savings are minimal with a lower dose.
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For me, money, sure. Also, if I rush to the highest dose asap, I’m probably missing some fat loss, possibly burning more muscle, and definitely losing faster than skin can adjust.
 
Lyophilized said:
Can I ask if you monitor your heart rate?
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I do monitor it. For the record I have had an elevated heart rate for a long time. Early last year my resting heart rate was consistently in the low 80s. When I started my new health regimen in July (diet, gym, walking, TRT) my resting heart rate dipped below 80 in August and began to rise again and was back to the low 80s in October. I started Reta at the end of October, and my bpm rose a bit more, peaking in the high 80s in mid-December. But since then to now, its been dropping. I am back in the low 80s and the trend line shows this will likely drop some more. So while I did see a bump up in heart rate from Reta, it appears to have been temporary.
 
headward said:
Why do people do 'lowest effective dose'? Why not just try to hit the 12mg max asap if that is what the trials show work? Is it to minimize side effects or to save money? Seems the cost savings are minimal with a lower dose.
Click to expand...
Because once you’re at the max you’ve been painted into a corner when tolerance kicks in. If you’re at a lower dose you can increase. If you’re at max dose you can either start stacking or exceed max, but that’s about it. So prob best not to rush to an unnecessarily high dose.
 
exploitedworkerbee said:
Because once you’re at the max you’ve been painted into a corner when tolerance kicks in. If you’re at a lower dose you can increase. If you’re at max dose you can either start stacking or exceed max, but that’s about it. So prob best not to rush to an unnecessarily high dose.
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This.
 
RoadRash said:
I started on 2 mg/ weekly and titrated up after two weeks to 4 mg/ weekly and will be at 4 mg for awhile. I started at 246 and after 5 weeks I'm at 228. Amazing. I am experiencing skin sensitivity which is irritating but other than that Im doing terrific.
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I did the exact same as you and I’m also experiencing the skin sensitivity. Annoying on legs and stomach
 
The main side after 3 weeks at 4mg week in a split dose is a slightly elevated heart rate. I am hoping this will go back to normal in time as I have no plans in coming off Reta, Ever. My diet is so much more healthy and no mental food cravings.
 
What exactly is "skin sensitivity"... pain, itch, burning or?
Are the symptoms localized or wide spread?
Do they present as a rash or raised surface?
 
Nerker said:
I'm in week #4 of 2mg. Lost 11lbs in first 2 weeks and 2lbs week #3.
I'm was considering heading up to 4mg this Sat (dose day).

Food noise is less but I also lock down into eating right really well. I have an appetite but also wouldn't have to eat, if that makes sense.
I think phase #3 trial held the dose for 4 weeks before titrating up.
I've read that by week #4 I'm finally getting the max effect or steady state of the 2mg dose.

Should I do all 4 weeks on 2mg? Anyone have thoughts? I'm honestly excited for more aggressive weight loss but can be patient too.
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I titrated up to 4mg .5mg a week to get there faster and avoid the GI side effects that I had on Tirz. Jumping from 2mg to 4mg could induce side effects (it would in me, but maybe not you!). So if you have no sides at 2mg maybe a 2 mg jump won't cause them. Managing side effects was the stated the reason they started at 2mg in the trials.
 
RetCurious said:
What exactly is "skin sensitivity"... pain, itch, burning or?
Are the symptoms localized or wide spread?
Do they present as a rash or raised surface?
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Is that to someone specifically or in general?

Can be localized or not, commonly described as some variety of a sunburn but no visual signs of the sensitive area.
 
Just got up to 8 mg this week, and skin sensitivity was confirmed: a slight tingling sensation, hard to describe, not painful at all, but I can notice the texture of many items of clothing when I otherwise would not have been able to.

Though that said, it's highly manageable for me at this time.

As for dosage escalation, I started relatively slow and low, but once I got to 3-4 mg, I made the executive decision for my next move to be more substantial, to 8 mg instead of a slower escalation, because I really haven't dealt with negative sides.

Positives have been there but much more in terms of body comp vs pure weight loss. I presume, having lost a lot with semaglutide a couple years back, the higher dosage is needed to really move the needle.
 
RetCurious said:
What exactly is "skin sensitivity"... pain, itch, burning or?
Are the symptoms localized or wide spread?
Do they present as a rash or raised surface?
Click to expand...
I tried to explain it today but I found it a bit difficult, there’s no rash or raised surface for me but it feels sensitive when rubbing against clothing, kind of like a prickly feeling sometimes, like almost pins and needles but not
 
Ultra_Unlimited said:
Just got up to 8 mg this week, and skin sensitivity was confirmed: a slight tingling sensation, hard to describe, not painful at all, but I can notice the texture of many items of clothing when I otherwise would not have been able to.

Though that said, it's highly manageable for me at this time.

As for dosage escalation, I started relatively slow and low, but once I got to 3-4 mg, I made the executive decision for my next move to be more substantial, to 8 mg instead of a slower escalation, because I really haven't dealt with negative sides.

Positives have been there but much more in terms of body comp vs pure weight loss. I presume, having lost a lot with semaglutide a couple years back, the higher dosage is needed to really move the needle.
Click to expand...
I've been on 4mg for two weeks, and two more to go on 4mg. I'm going to decide if we want to jump to 8mg or stay at 4mg for a while after my results in about a week and a half. I've been dropping 3lbs a week. Started at 2mg. Looking forward to your results.
 
RetCurious said:
What exactly is "skin sensitivity"... pain, itch, burning or?
Are the symptoms localized or wide spread?
Do they present as a rash or raised surface?
Click to expand...
My skin sensitivity feels very much like a sunburn. Clothing is a little uncomfortable when it rubs against whatever area is sensitive.

Mine has never reached the "painful" threshold, just noticeable and mildly uncomfortable at worst.
 
Hello from the UK.

I've just started today at 2 mg. So wish me luck.

I've previously been on Mounjaro and reached 15mg, but the last dose was over a month ago.

It will be interesting to see how it feels.

I sourced a single vial from the UK supplier. (Obviously, I paid too much!), but depending on how it goes I'm looking at buying kits from China, like everybody else. I just want to check i get on ok with Reta, as may revert back to Tirz so didnt want to make a big order.
 
I just upped my dose to 2 mg this morning after two weeks of 1 mg. For the record, I've been on Ozempic since February 2024 and took my last Ozempic jab last week.
 
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