Any grey peptides for migraine headache

[swimmer]

I have suffered migraines my whole life. The current medications covered by my insurance (emitrex, maxalt) give me horrible side effects. The newer prophylactic migraine medications like Emgality, Amovig are not covered. They are in a family of drugs called calcitronin gene related peptide antagonists CGRP inhibitors. I can't afford any of these new wonder drugs without insurance coverage. I am new to the "grey research drugs" . Does anyone know of a source for any research CGRP antagonist drugs?

 

[desinr-gal]

Search this forum for "migraine" a lot pops up.
I saw that Someone on Reddit said that hers completely stopped after starting Glo..
I have heard others say that Botox is effective, and best to go to someone specialized for that purpose.

 

[swimmer]

My insurance does cover botox for migraines. I have heard mixed results. I have ordered some of the components of GLOW and I am waiting for delivery. I'm sure there would be a large market for grey CGRP inhibitors.

 

[Spanee01]

I’d love to find a peptides too. DOA from seeking health helped tremendously. Also the book Heal Your Headaches is the GOAT. The program isn’t easy to follow but it helps a ton.

 

[swimmer]

I’d love to find a peptides too. DOA from seeking health helped tremendously. Also the book Heal Your Headaches is the GOAT. The program isn’t easy to follow but it helps a ton.

Thank you for the tip. I see a product on Amazon called histamine digest from seeking health. DAO enzyme supplement is that the one?

 

[Jack brown]

I pin 2.8mg GLOW and my migraines dissappear in 15mins, it's like I've discovered a life hack.

 

[Jack brown]

I pin 2.8mg GLOW and my migraines dissappear in 15mins, it's like I've discovered a life hack.

This also works for me just taking GHKcu, so that must be it. It's s way underrated peptide,modifies gene expression for over 6000 genes. From anecdotes it seems it impacts everyone in different ways.

 

[Spanee01]

Thank you for the tip. I see a product on Amazon called histamine digest from seeking health. DAO enzyme supplement is that the one?

Yes it is. It is expensive. Take it with every meal 15 minutes before you eat. Histamine (not just the allergies type) sets of neurotransmitters that can cause headaches. I take GABA, taurine, and choline along with DOA and my migraines, sinus pain, joint pain is significantly reduced. All the prescriptions didn’t help. The heal your headache explains the glutamine rich foods that set off the reaction. Aged meats and cheeses, yogurt, sour cream. All the good stuff. DOA is an enzyme that neutralizes the histamines triggered from what we eat. Reddit has good info on histamine intolerance just avoid the folks that are on their talking about season allergy reactions. It’s not the same. Dirty Genes is also a good book.

There are cheaper plant based DOA sources. Didn’t help me. Try the seeming health brand first. If you notice improvement, then try the cheaper ones.

 

[swimmer]

This also works for me just taking GHKcu, so that must be it. It's s way underrated peptide,modifies gene expression for over 6000 genes. From anecdotes it seems it impacts everyone in different ways.

I just ordered that peptide from the SRY USA warehouse this morning. Now I will have all the components of GLOW. I'm excited. If it works for me that would improve my life as much as trizepatide!!!

 

[swimmer]

Yes it is. It is expensive. Take it with every meal 15 minutes before you eat. Histamine (not just the allergies type) sets of neurotransmitters that can cause headaches. I take GABA, taurine, and choline along with DOA and my migraines, sinus pain, joint pain is significantly reduced. All the prescriptions didn’t help. The heal your headache explains the glutamine rich foods that set off the reaction. Aged meats and cheeses, yogurt, sour cream. All the good stuff. DOA is an enzyme that neutralizes the histamines triggered from what we eat. Reddit has good info on histamine intolerance just avoid the folks that are on their talking about season allergy reactions. It’s not the same. Dirty Genes is also a good book.

There are cheaper plant based DOA sources. Didn’t help me. Try the seeming health brand first. If you notice improvement, then try the cheaper ones.

I just ordered the book, and the Suppliment from Amazon. Thank you!!

 

[Spanee01]

I just ordered the book, and the Suppliment from Amazon. Thank you!!

I hope it helps. I bought the book over 10 years ago and didn’t try the plan because I thought it was to hard. I had a horrible migraine and noticed that many of the trigger foods I had recently eaten. Yogurt, deli meat. For me migraines and histamine triggering foods are one and the same. The Facebook group Migraine strong was set up as a support group related to the book.

 

[swimmer]

This also works for me just taking GHKcu, so that must be it. It's s way underrated peptide,modifies gene expression for over 6000 genes. From anecdotes it seems it impacts everyone in different ways.

What is your dosage of GHK-cu?

 

[Heidi1953]

I have not found a peptide for migraines yet. I've tried many including ghkcu, glow, klow, ......The only med (prescription) that works for me without too many side effects is an old one probably no longer available with its original name of fioricet, fiorinal, still available in generic. No magnified migraine symptoms or nausea/vomiting. https://en.wikipedia.org/wiki/Butalbital/acetaminophen. They still manage to charge $$ but worth every penny penny for me.

 

[desinr-gal]

Yes it is. It is expensive. Take it with every meal 15 minutes before you eat. Histamine (not just the allergies type) sets of neurotransmitters that can cause headaches. I take GABA, taurine, and choline along with DOA and my migraines, sinus pain, joint pain is significantly reduced. All the prescriptions didn’t help. The heal your headache explains the glutamine rich foods that set off the reaction. Aged meats and cheeses, yogurt, sour cream. All the good stuff. DOA is an enzyme that neutralizes the histamines triggered from what we eat. Reddit has good info on histamine intolerance just avoid the folks that are on their talking about season allergy reactions. It’s not the same. Dirty Genes is also a good book.

There are cheaper plant based DOA sources. Didn’t help me. Try the seeming health brand first. If you notice improvement, then try the cheaper ones.

Dont forget Wine, many kinds have a lot of histamines.

 

[swimmer]

Yesterday I woke up with a mild Migraine. I pinned ghk-cu for the first time. 15 min. later it was gone. Today I don't even have a rebound migraine like Maxalt usually gives. It seems too good to be true!!! I am not going to get my Hope's up till it works on a severe migraine.

 

[swimmer]

I have been pinning it every day for the last 14 days and I have not yet had a severe migraine. I am definately having less migraines. I have had several mild ones mostly while researching 5-amino1 . The mild ones don't last long. I thought my dosage was 2 mg per day but I think I have the SRY overfill. If I have the overfill ghk-cu, my dosage has been a little more than 4 mg per day. I had no signs of doing too much.

 

[Jack brown]

I have been pinning it every day for the last 14 days and I have not yet had a severe migraine. I am definately having less migraines. I have had several mild ones mostly while researching 5-amino1 . The mild ones don't last long. I thought my dosage was 2 mg per day but I think I have the SRY overfill. If I have the overfill ghk-cu, my dosage has been a little more than 4 mg per day. I had no signs of doing too much.

It's amazing the different effects GHKcu has on people, its a much underrated peptide! Has more research and support than TB500 or BPC157.

 

[Peotidethrowaway]

I’ve had migraines since probably middle school. Beyond the migraines I’d get mild to moderate nearly daily headaches. I take Aimovig once a month. It knocked the migraine days down but not the routine headache days.

Strangely since I started tirz I don’t really get headaches anymore. I do not know why. Reduced inflammation is all I can think

When I went from tirz to Reta they came back. Back to tirz they went away. I still take the Aimovig because I’m afraid to make any changes since I’m doing pretty great.

YMMV but tb4 and bpc157 gives me headaches

I’ve o labored ghkcu in glow with bpc and tb4 and got headaches so I guess I should try some ghkcu by itself

 

[swimmer]

I’ve had migraines since probably middle school. Beyond the migraines I’d get mild to moderate nearly daily headaches. I take Aimovig once a month. It knocked the migraine days down but not the routine headache days.

Strangely since I started tirz I don’t really get headaches anymore. I do not know why. Reduced inflammation is all I can think

When I went from tirz to Reta they came back. Back to tirz they went away. I still take the Aimovig because I’m afraid to make any changes since I’m doing pretty great.

YMMV but tb4 and bpc157 gives me headaches

I’ve o labored ghkcu in glow with bpc and tb4 and got headaches so I guess I should try some ghkcu by itself

Thank you for sharing your experience. I was pretty sure that tirz decreased my headaches as well. I wish my insurance covered aimovig. It would be great if Aimovig or something similar was available at one of our grey vendors. I haven't tried tb 4 or 5 yet. I did suspect bpc157 might have made the headaches worse. 5-amino 1mq definitely caused migraines for me. I am excited about ghk-cu. I hope my system does not create a resistance to it.

 

[Peotidethrowaway]

Thank you for sharing your experience. I was pretty sure that tirz decreased my headaches as well. I wish my insurance covered aimovig. It would be great if Aimovig or something similar was available at one of our grey vendors. I haven't tried tb 4 or 5 yet. I did suspect bpc157 might have made the headaches worse. 5-amino 1mq definitely caused migraines for me. I am excited about ghk-cu. I hope my system does not create a resistance to it.

If you think of it, please do post your ghost-cu experiences.

I also wish there were grey cgrp meds. Maybe some day

 

[lessthanhalf]

I am taking tirzepatide 15 mg and started adding in reta a few weeks ago, was at about 4mg/week. ( I am trying to maintain a 50% weight loss ) Got two migraines in a row both starting at 5 or 6 am last week and then 7 days in a row this week, most starting early am . I have had migraines since forever but never this many in a short time. Eletriptan works well and quickly for me, but is not a great idea to take it every day for a week. Retatrutide is the only recent change I can think of that might have caused this, so I am stopping it for now and will see what happens. And maybe try restarting it slowly once they are gone. Bit of a pity as i have been losing 0.5kg a week the last few weeks, and only 450 grams to go to get to exactly half my start weight. I don't have any of the above mentioned peptides on hand to try, at this stage i would try almost anything to stop this burst of migraines.

 

[RubbaDubba1]

I have not found a peptide for migraines yet. I've tried many including ghkcu, glow, klow, ......The only med (prescription) that works for me without too many side effects is an old one probably no longer available with its original name of fioricet, fiorinal, still available in generic. No magnified migraine symptoms or nausea/vomiting. https://en.wikipedia.org/wiki/Butalbital/acetaminophen. They still manage to charge $$ but worth every penny penny for me.

I know this an older post, but I wanted to pass along some advice I got for headaches about a year ago from my longevity Dr. He told me that CJC-1295 No Dac with Ipamorelin helps with headaches. I had ordered some CJC-1295 No Dac with Ipamorelin from him (which I get gray market now) to use when I started working out. Anyways that never really happened haha, but tried it on a whim 9 months later when I was on 6 day headache. BAM! Woke up for work, with it 90% gone. Further researching on my part, it's the Ipamorelin that works on the headaches. I take it on an empty stomach before bed, 5 days a week. Generally 2-300mcg and that does the trick. There is also, Tesamorelin that seems to work for me and Sermorelin I have, but haven't tried it yet for headaches yet.

I hope this can help you or anyone else that is a headache sufferer. I just joined the Forum here (Former Reddit junkie) and am searching through my different ailments to see which peptides might apply.

 

[swimmer]

I know this an older post, but I wanted to pass along some advice I got for headaches about a year ago from my longevity Dr. He told me that CJC-1295 No Dac with Ipamorelin helps with headaches. I had ordered some CJC-1295 No Dac with Ipamorelin from him (which I get gray market now) to use when I started working out. Anyways that never really happened haha, but tried it on a whim 9 months later when I was on 6 day headache. BAM! Woke up for work, with it 90% gone. Further researching on my part, it's the Ipamorelin that works on the headaches. I take it on an empty stomach before bed, 5 days a week. Generally 2-300mcg and that does the trick. There is also, Tesamorelin that seems to work for me and Sermorelin I have, but haven't tried it yet for headaches yet.

I hope this can help you or anyone else that is a headache sufferer. I just joined the Forum here (Former Reddit junkie) and am searching through my different ailments to see which peptides might apply.

Thank you for the info. I have not tried cjc 1295 yet. I cycle Ipamorelin and tessamorelin. That combo definitely did not make migraines worse. The peptides that I have tried that seem to help are: glutathione, gck-cu, KPV. I cycle glutathione at 100mg per day with subq vitamin c. Either oral (1500mg/day) or sub q cut down frequency and intensity by more than 50% TB-500, bpc-157, 5amino1 made migraines worse. Especially 5-amino1.

 

[Labcat]

I know this an older post, but I wanted to pass along some advice I got for headaches about a year ago from my longevity Dr. He told me that CJC-1295 No Dac with Ipamorelin helps with headaches. I had ordered some CJC-1295 No Dac with Ipamorelin from him (which I get gray market now) to use when I started working out. Anyways that never really happened haha, but tried it on a whim 9 months later when I was on 6 day headache. BAM! Woke up for work, with it 90% gone. Further researching on my part, it's the Ipamorelin that works on the headaches. I take it on an empty stomach before bed, 5 days a week. Generally 2-300mcg and that does the trick. There is also, Tesamorelin that seems to work for me and Sermorelin I have, but haven't tried it yet for headaches yet.

I hope this can help you or anyone else that is a headache sufferer. I just joined the Forum here (Former Reddit junkie) and am searching through my different ailments to see which peptides might apply.

@RubbaDubba1 @swimmer @Jack brown and others, this is a fantastic thread and thank you and all who contributed. I’ve had lifetime migraines and since covid have been having migraines and other headaches more days than not even with neurology supervision of my medications (ajovy, nurtec, fioricet, propranolol), and then my migraines got significantly more intense 😒 on tirz (but others things got better so I kept upping my dose lol, thank goodness for aspirin and having saved up some fioricet). I’m coming off tirz now because it makes me too sleepy, physically weak, plus muscle loss, and unable to eat (with mild weight loss), but I’m going to try it again sometime now that I’m aware of peptides. I’ll try your great suggestions first. I just started ss31 a few days ago (and there is a lot of conjecture in the migraine literature that migraine is a mitochondrial disease) and so far it’s promising. If I can’t find this thread to report back, feel free to DM me if you want to know what happens.

I was told that by specialists at stanford a few years ago that they believe constant migraines cause cumulative brain injury. (They didn’t offer treatment and their clinic was too backed up and $$$$). So this is all very hopeful (edited for clarity)

 

[Not_Your_Dad]

Just to be contrarian to all of you fine folks, I had the exact opposite effect from tesamorelin.

I was about 6 weeks in to a cycle, and I woke up one night with a migraine. Not especially unusual for me - maybe I didn't have caffeine late enough, maybe my CPAP was whack, whatever. That was a Wednesday. Happened again on Thursday, but worse. Woke up on Friday around 3:30a with such an intense migraine I was considering going to the Emergency Room.

I then realized that, for the past week, I had little itchy spots on my abdomen. Also not terribly unusual, but then it dawned on me, they were where I had pinned my 2mg tesamorelin dose in the PM. I seemed to be having an escalating histamine response to it. I stopped taking the tesa, and the migraine went away the very next night. I was pinning CJC1295 no-dac and Ipamorelin at the same time (I was really just after the Ipa, but my vendor didn't have a Tesa/Ipa blend in stock at the moment). I've continued the CJC/IPA, but dropped down to just an AM pin. I may return to the evening pin as well just to see.

Anywho, that's my story with Tesamorelin and migraines. I don't know that I'll be returning to my tesa cycle after this experience!

 

[swimmer]

Just to be contrarian to all of you fine folks, I had the exact opposite effect from tesamorelin.

I was about 6 weeks in to a cycle, and I woke up one night with a migraine. Not especially unusual for me - maybe I didn't have caffeine late enough, maybe my CPAP was whack, whatever. That was a Wednesday. Happened again on Thursday, but worse. Woke up on Friday around 3:30a with such an intense migraine I was considering going to the Emergency Room.

I then realized that, for the past week, I had little itchy spots on my abdomen. Also not terribly unusual, but then it dawned on me, they were where I had pinned my 2mg tesamorelin dose in the PM. I seemed to be having an escalating histamine response to it. I stopped taking the tesa, and the migraine went away the very next night. I was pinning CJC1295 no-dac and Ipamorelin at the same time (I was really just after the Ipa, but my vendor didn't have a Tesa/Ipa blend in stock at the moment). I've continued the CJC/IPA, but dropped down to just an AM pin. I may return to the evening pin as well just to see.

Anywho, that's my story with Tesamorelin and migraines. I don't know that I'll be returning to my tesa cycle after this experience!

I had to drop to 1mg per day for the Tesa in the ipa/Tesa stack. It increased my heart rate and I retained water like crazy on 2mg.

 

[Labcat]

I’ve recently heard numerous reaction stories with tesa, it sounds like the reaction could have been driving your migraine? If it was histamine, it could have definitely potentiated migraine by causing inflammation and blood vessel dilation.