Day one

[zpped]

Either way, once it maxes out on effectiveness, there is nowhere to go if you’re already hitting all the receptors.

I can use a rock to push a nail into the board and then switch the better tool to make more progress or I could just use the hammer to begin with. Someday someone will invent a better hammer.

 

[AndyPanda]

I can use a rock to push a nail into the board and then switch the better tool to make more progress or I could just use the hammer to begin with. Someday someone will invent a better hammer.

You could go straight to morphine for pain, but if ibuprofen works, why would you?

 

[zpped]

You could go straight to morphine for pain, but if ibuprofen works, why would you?

because morphine has terrible side effects? And it's a rare class of drug that does build tolerance.


Reta has LESS side effects than tirz

 

[AndyPanda]

because morphine has terrible side effects? And it's a rare class of drug that does build tolerance.


Reta has LESS side effects than tirz

You are overthinking this and appear to be responding emotionally. Retatrutide works, but If you are maxed out on it, and it’s no longer effective, what is your next option? If you’re on Semaglutide and it stops working, you can go to Tirzepatide. If you are on Tirzepatide and it stops working, you go to Retatrutide. Let’s also not forget that Retatrutide is still not approved for human use. Anywhere.

 

[GLP1Pharmacist]

You are overthinking this and appear to be responding emotionally. Retatrutide works, but If you are maxed out on it, and it’s no longer effective, what is your next option? If you’re on Semaglutide and it stops working, you can go to Tirzepatide. If you are on Tirzepatide and it stops working, you go to Retatrutide. Let’s also not forget that Retatrutide is still not approved for human use. Anywhere.

Low dose Semaglutide or Cagrilintide stack on Retatrutide?

But I do agree in general- Semaglutide then Tirzepatide then Retatrutide if needed. Makes a difference imho if you need to lose 30lbs vs 100+lbs.

 

[zpped]

You are overthinking this and appear to be responding emotionally. Retatrutide works, but If you are maxed out on it, and it’s no longer effective, what is your next option? If you’re on Semaglutide and it stops working, you can go to Tirzepatide. If you are on Tirzepatide and it stops working, you go to Retatrutide. Let’s also not forget that Retatrutide is still not approved for human use. Anywhere.

I'm definitely not emotional. And you're completely misunderstanding the point. There is no benefit to starting with semaglutide. The only thing you get is slower progress and more side effects.

Your understanding of how it works is just wrong. Starting with Sema and switching to Tirz dosn't give you a greater overall loss than just starting with Tirz.

They aren't additive.

Makes a difference imho if you need to lose 30lbs vs 100+lbs.

It really doesn't make a difference.

 

[kaahhllll]

Week eleven:

Down another 4lbs this week, continuing on at 1.0mg, but I'm considering titrating up again next week. I haven't had shit for an appetite, but I have felt hungry more lately. I don't like the discomfort of feeling hungry, especially when nothing sounds good enough to change that.

My girlfriend has been on compound sema for almost a year now and has lost about 70lbs. I am 70 days in and have lost half that on extremely small doses of reta. I can't see any reason to worry about tolerances or effectiveness. But also, what about that chart that shows the "strength" of each pep in relation to one another? If tirz has significantly less GLP1 than sema, and reta has significantly less GLP1 and GIC than tirz, what would make someone believe that the former would be rendered ineffective due to use of the latter? They work on different agonists, that's the whole reason for having different compounds.

 

[zpped]

Week eleven:

Down another 4lbs this week, continuing on at 1.0mg, but I'm considering titrating up again next week. I haven't had shit for an appetite, but I have felt hungry more lately. I don't like the discomfort of feeling hungry, especially when nothing sounds good enough to change that.

My girlfriend has been on compound sema for almost a year now and has lost about 70lbs. I am 70 days in and have lost half that on extremely small doses of reta. I can't see any reason to worry about tolerances or effectiveness. But also, what about that chart that shows the "strength" of each pep in relation to one another? If tirz has significantly less GLP1 than sema, and reta has significantly less GLP1 and GIC than tirz, what would make someone believe that the former would be rendered ineffective due to use of the latter? They work on different agonists, that's the whole reason for having different compounds.

I find the hunger cravings come from not having enough of a given macro. So I just figure out which one it is and try to satisfy that. Also eating more calorie dense foods that don't physically fill you up as fast. 4 lbs in a week is a lot.

 

[kaahhllll]

I find the hunger cravings come from not having enough of a given macro. So I just figure out which one it is and try to satisfy that. Also eating more calorie dense foods that don't physically fill you up as fast. 4 lbs in a week is a lot.

It does seem like a lot, but that's about the average for me throughout this whole period. According to Samsung health, I've been in about a 1500cal defecit every day and I am retaining muscle mass, so I'm not concerned with the rate of loss. Still trying to stick to higher protein than anything for the satiety. And I've been making sure I get a fair amount of fiber and low net carbs. The keto bread world is fantastic by the way, I will buy burger patties from fast food places and throw them on keto buns for 50cal each at like 1g net carbs. Get the filling effect of the bread and still hit my macros pretty well. Only bad thing is that samsung health counts total carbs and doesnt adjust for net carbs offset by fiber, so my tracker looks more carb heavy than it actually is. But I'm averaging TDEE of about 2,900cal, consuming an average of 1700cal, and I have plenty of energy throughout the day.