Day one

[zpped]

Either way, once it maxes out on effectiveness, there is nowhere to go if you’re already hitting all the receptors.

I can use a rock to push a nail into the board and then switch the better tool to make more progress or I could just use the hammer to begin with. Someday someone will invent a better hammer.

 

[AndyPanda]

I can use a rock to push a nail into the board and then switch the better tool to make more progress or I could just use the hammer to begin with. Someday someone will invent a better hammer.

You could go straight to morphine for pain, but if ibuprofen works, why would you?

 

[zpped]

You could go straight to morphine for pain, but if ibuprofen works, why would you?

because morphine has terrible side effects? And it's a rare class of drug that does build tolerance.


Reta has LESS side effects than tirz

 

[AndyPanda]

because morphine has terrible side effects? And it's a rare class of drug that does build tolerance.


Reta has LESS side effects than tirz

You are overthinking this and appear to be responding emotionally. Retatrutide works, but If you are maxed out on it, and it’s no longer effective, what is your next option? If you’re on Semaglutide and it stops working, you can go to Tirzepatide. If you are on Tirzepatide and it stops working, you go to Retatrutide. Let’s also not forget that Retatrutide is still not approved for human use. Anywhere.

 

[GLP1Pharmacist]

You are overthinking this and appear to be responding emotionally. Retatrutide works, but If you are maxed out on it, and it’s no longer effective, what is your next option? If you’re on Semaglutide and it stops working, you can go to Tirzepatide. If you are on Tirzepatide and it stops working, you go to Retatrutide. Let’s also not forget that Retatrutide is still not approved for human use. Anywhere.

Low dose Semaglutide or Cagrilintide stack on Retatrutide?

But I do agree in general- Semaglutide then Tirzepatide then Retatrutide if needed. Makes a difference imho if you need to lose 30lbs vs 100+lbs.

 

[zpped]

You are overthinking this and appear to be responding emotionally. Retatrutide works, but If you are maxed out on it, and it’s no longer effective, what is your next option? If you’re on Semaglutide and it stops working, you can go to Tirzepatide. If you are on Tirzepatide and it stops working, you go to Retatrutide. Let’s also not forget that Retatrutide is still not approved for human use. Anywhere.

I'm definitely not emotional. And you're completely misunderstanding the point. There is no benefit to starting with semaglutide. The only thing you get is slower progress and more side effects.

Your understanding of how it works is just wrong. Starting with Sema and switching to Tirz dosn't give you a greater overall loss than just starting with Tirz.

They aren't additive.

Makes a difference imho if you need to lose 30lbs vs 100+lbs.

It really doesn't make a difference.

 

[kaahhllll]

Week eleven:

Down another 4lbs this week, continuing on at 1.0mg, but I'm considering titrating up again next week. I haven't had shit for an appetite, but I have felt hungry more lately. I don't like the discomfort of feeling hungry, especially when nothing sounds good enough to change that.

My girlfriend has been on compound sema for almost a year now and has lost about 70lbs. I am 70 days in and have lost half that on extremely small doses of reta. I can't see any reason to worry about tolerances or effectiveness. But also, what about that chart that shows the "strength" of each pep in relation to one another? If tirz has significantly less GLP1 than sema, and reta has significantly less GLP1 and GIC than tirz, what would make someone believe that the former would be rendered ineffective due to use of the latter? They work on different agonists, that's the whole reason for having different compounds.

 

[zpped]

Week eleven:

Down another 4lbs this week, continuing on at 1.0mg, but I'm considering titrating up again next week. I haven't had shit for an appetite, but I have felt hungry more lately. I don't like the discomfort of feeling hungry, especially when nothing sounds good enough to change that.

My girlfriend has been on compound sema for almost a year now and has lost about 70lbs. I am 70 days in and have lost half that on extremely small doses of reta. I can't see any reason to worry about tolerances or effectiveness. But also, what about that chart that shows the "strength" of each pep in relation to one another? If tirz has significantly less GLP1 than sema, and reta has significantly less GLP1 and GIC than tirz, what would make someone believe that the former would be rendered ineffective due to use of the latter? They work on different agonists, that's the whole reason for having different compounds.

I find the hunger cravings come from not having enough of a given macro. So I just figure out which one it is and try to satisfy that. Also eating more calorie dense foods that don't physically fill you up as fast. 4 lbs in a week is a lot.

 

[kaahhllll]

I find the hunger cravings come from not having enough of a given macro. So I just figure out which one it is and try to satisfy that. Also eating more calorie dense foods that don't physically fill you up as fast. 4 lbs in a week is a lot.

It does seem like a lot, but that's about the average for me throughout this whole period. According to Samsung health, I've been in about a 1500cal defecit every day and I am retaining muscle mass, so I'm not concerned with the rate of loss. Still trying to stick to higher protein than anything for the satiety. And I've been making sure I get a fair amount of fiber and low net carbs. The keto bread world is fantastic by the way, I will buy burger patties from fast food places and throw them on keto buns for 50cal each at like 1g net carbs. Get the filling effect of the bread and still hit my macros pretty well. Only bad thing is that samsung health counts total carbs and doesnt adjust for net carbs offset by fiber, so my tracker looks more carb heavy than it actually is. But I'm averaging TDEE of about 2,900cal, consuming an average of 1700cal, and I have plenty of energy throughout the day.

 

[zpped]

I think you might feel less hungry if you added an extra 200 calories of regular carbs. Reta does really well for a lot of people when you feed it carbs

I'd cut back on the fat and greatly increase the carbs and protein. I'm only suggesting a change because you mentioned its not working exactly how you want. Your method is obviously working though. Higher protein will also give you longer satiety.

 

[BooneDonk]

I think you might feel less hungry if you added an extra 200 calories of regular carbs. Reta does really well for a lot of people when you feed it carbs

I will agree with this x1,000

 

[kaahhllll]

I was a little put off by the fat amount. But majority of that is from beef, some times cheese and it really adds up. I'll definitely try to cut down on fat, and I'll give it a try to add in some more carbs. It's tough though, because there have been a few days that are higher on carbs and I'm certainly feeling way hungrier on those days, its such an empty macro

 

[zpped]

I was a little put off by the fat amount. But majority of that is from beef, some times cheese and it really adds up. I'll definitely try to cut down on fat, and I'll give it a try to add in some more carbs. It's tough though, because there have been a few days that are higher on carbs and I'm certainly feeling way hungrier on those days, its such an empty macro

What kind of carbs are you eating? I find rice pretty filling. Now that I'm trying to gain weight I eat more beef but I was definitely eating a lot of chicken in the beggining.

 

[kaahhllll]

What kind of carbs are you eating? I find rice pretty filling. Now that I'm trying to gain weight I eat more beef but I was definitely eating a lot of chicken in the beggining.

Typically rice or potatoes, sometimes protein pasta. Occasionally its sweets or "junk" like poptarts or a rice crispy treats, sometimes chips, but that's when I'm dying before lunch and hit the vending machine at work. I try to stay chicken heavy. But I am big on burgers and steak. I've always been more of a red meat guy.

 

[BooneDonk]

Typically rice or potatoes, sometimes protein pasta. Occasionally its sweets or "junk" like poptarts or a rice crispy treats, sometimes chips, but that's when I'm dying before lunch and hit the vending machine at work. I try to stay chicken heavy. But I am big on burgers and steak. I've always been more of a red meat guy.

Chickens aren’t nearly as personable as cows. I think it’s because they don’t have eyelashes. I’m with you on the red meat.

 

[zpped]

Typically rice or potatoes, sometimes protein pasta. Occasionally its sweets or "junk" like poptarts or a rice crispy treats, sometimes chips, but that's when I'm dying before lunch and hit the vending machine at work. I try to stay chicken heavy. But I am big on burgers and steak. I've always been more of a red meat guy.

Oh I love beef. But I switched to flap steak mostly for lower fats.

 

[kaahhllll]

Week twelve:

I'm unsure if its these work trips out of town that are fucking me up, or if its that I need to titrate up. Gained back a net of 3lbs this week, and at one point I was back up to 270 during the week. I did 1mg again yesterday, but I am considering doing another 0.5mg on Friday and doing 1.5mg/week moving forward. I'll see how the next couple days go. I will say, I've been very fatigued over the last week or so, and had a pretty aggressive cold or viral URI/sinus infection 2 weeks ago. I'm holding onto a lot of water right now and haven't pooped much recently. I'm thinking my whole system is messed up from being sick and I'll bounce back pretty well soon.

I did try getting in some good carbs throughout the day and I dont see or feel much of a difference, but again, I haven't been feeling well. I also increased my intake a fair bit over the week as per suggestions, and that could be whats thrown everything off. I averaged 1950cal vs the 1650-1700 I had been consistent with. All and all, I think the higher defecit worked a lot better for me and I plan on returning to it.

 

[zpped]

Week twelve:

I'm unsure if its these work trips out of town that are fucking me up, or if its that I need to titrate up. Gained back a net of 3lbs this week, and at one point I was back up to 270 during the week. I did 1mg again yesterday, but I am considering doing another 0.5mg on Friday and doing 1.5mg/week moving forward. I'll see how the next couple days go. I will say, I've been very fatigued over the last week or so, and had a pretty aggressive cold or viral URI/sinus infection 2 weeks ago. I'm holding onto a lot of water right now and haven't pooped much recently. I'm thinking my whole system is messed up from being sick and I'll bounce back pretty well soon.

I did try getting in some good carbs throughout the day and I dont see or feel much of a difference, but again, I haven't been feeling well. I also increased my intake a fair bit over the week as per suggestions, and that could be whats thrown everything off. I averaged 1950cal vs the 1650-1700 I had been consistent with. All and all, I think the higher defecit worked a lot better for me and I plan on returning to it.

Travel and illness can definitely throw everything off for a bit.

 

[kaahhllll]

Travel and illness can definitely throw everything off for a bit.

Yeah I get that, so I am remaining very positive and staying encouraged. It does suck to see things go backward though

 

[kaahhllll]

Week thirteen:

Bumped up to 1.5mg this week due to the plateau. I've noticed I'm thinking about food a lot more lately, and snacking more. I also started a break from KLOW and CJC/IPA on Friday. Trying to decide if I'm waiting one week or two before restarting those cycles.

I will be returning to the gym this week finally, so I'm sure that will help. I have been pretty consistently around 1800cal/day.

 

[50ShadesGreyMarket]

I started Aug 6th at 1mg every 4-5 days, averaging 2-3 1mg doses per week up until yesterday when I weighed myself and realized I went from 5’11” 145-150lbs to 132lbs in just under 4 weeks. I’m also on .25 Sema once a week, lost my appetite completely starting the first day, it was mostly due to waves of nausea. I take Ondansetron (Zofran) for the nausea but I had about 4~ days of pure exhaustion which I can’t do anything for. This week I decided to pull back to .5 every 5-7 days and see if that helps with the appetite and the need to take a nap the day after injection. According to my scale BF is 24% but not sure how accurate that is. Hoping to regain appetite enough to get back to 140 lbs, don’t want to lose muscle but exhaustion makes it tough to ride the Peloton even at a low resistance.

Overall my biggest issue is exhaustion and the first week was insane heartburn but that’s better now. I will feel “hungry” once in a while but a few bites of food feels like Thanksgiving dinner. I suggest if you’re going for weight loss, stick with foods that are nutrient dense, avoid useless fats and eat small portions so your body has time to acknowledge that you’re not hungry. If you can’t do cardio get out and walk, fresh air and sunshine will keep your mood up.

 

[kaahhllll]

I started Aug 6th at 1mg every 4-5 days, averaging 2-3 1mg doses per week up until yesterday when I weighed myself and realized I went from 5’11” 145-150lbs to 132lbs in just under 4 weeks. I’m also on .25 Sema once a week, lost my appetite completely starting the first day, it was mostly due to waves of nausea. I take Ondansetron (Zofran) for the nausea but I had about 4~ days of pure exhaustion which I can’t do anything for. This week I decided to pull back to .5 every 5-7 days and see if that helps with the appetite and the need to take a nap the day after injection. According to my scale BF is 24% but not sure how accurate that is. Hoping to regain appetite enough to get back to 140 lbs, don’t want to lose muscle but exhaustion makes it tough to ride the Peloton even at a low resistance.

Overall my biggest issue is exhaustion and the first week was insane heartburn but that’s better now. I will feel “hungry” once in a while but a few bites of food feels like Thanksgiving dinner. I suggest if you’re going for weight loss, stick with foods that are nutrient dense, avoid useless fats and eat small portions so your body has time to acknowledge that you’re not hungry. If you can’t do cardio get out and walk, fresh air and sunshine will keep your mood up.

If you look back through, I dropped 25lbs in the first 3 weeks, all fat according to body comp measurements. I was almost taking in as much protein as I could with minimal fats or carbs, mostly whole foods at around 1600cal/day. No real side effects to speak of at 0.5mg once per week. Even still to this day, no side effects. I will say however, when I was regularly going to the gym I felt much better throughout each day. Isn't 3mg/week kind of high for starting dosing?

 

[zpped]

If you look back through, I dropped 25lbs in the first 3 weeks, all fat according to body comp measurements. I was almost taking in as much protein as I could with minimal fats or carbs, mostly whole foods at around 1600cal/day. No real side effects to speak of at 0.5mg once per week. Even still to this day, no side effects. I will say however, when I was regularly going to the gym I felt much better throughout each day. Isn't 3mg/week kind of high for starting dosing?

3mg is a little high for a starting dose (but not crazy). I'm more concerned that they are 5'11" and ~130lbs... they don't need to loose weight, they need to workout.

 

[kaahhllll]

3mg is a little high for a starting dose (but not crazy). I'm more concerned that they are 5'11" and ~130lbs... they don't need to loose weight, they need to workout.

I've been seeing a lot of body builders using reta to get a better cut and drop BF% rather than for weight loss due to being overweight. I'm curious if that's what their goal is.