If you were a newb... would you start with Tirz or Reta first?

[LetsMakeMayhem]

**Not Asking for Medical Advice**
**Asking for personal perspectives only**

Hi All,
For those that have been on the weight loss journey with GLP-1s, if you had to start over all over again would you go with Triz or Reta as your first GLP?

Personally, I am thinking about starting Triz first and then moving on to Reta at a later time. Someone told me to "keep my options open" in case my progress stalls on one peptide so that I have still have other options. I know each of our bodies are different and we may not have the same experience on the same peptides, but just trying to figure out a great starting point.

Additionally, how you do feel about me stacking Amino 5 1 MQ while starting my first GLP? This was some information that was told to me by multiple people (as to avoid losing muscle mass, though I am exercising and doing cardio already).

Keep in mind, I've been a fata*s my whole life, even as a child. My metabolism is just garbage and needs some help. I've lost over 60lbs+ on diet changes and cardio alone, but I haven't been able to get the rest of this off. Thanks in advance for your insight

 

[indolent]

Have you first used the search function at the top, and the table of contents under the top-level Forums tab?

 

[LetsMakeMayhem]

Yes, but didn't locate exactly what I was looking for. I located general information about Reta raising HR and RHR but that is about it.

Maybe I'm not finessing the search filters good enough.

 

[penewbie]

Tirz.

 

[AndyPanda]

**Not Asking for Medical Advice**
**Asking for personal perspectives only**

Hi All,
For those that have been on the weight loss journey with GLP-1s, if you had to start over all over again would you go with Triz or Reta as your first GLP?

Personally, I am thinking about starting Triz first and then moving on to Reta at a later time. Someone told me to "keep my options open" in case my progress stalls on one peptide so that I have still have other options. I know each of our bodies are different and we may not have the same experience on the same peptides, but just trying to figure out a great starting point.

Additionally, how you do feel about me stacking Amino 5 1 MQ while starting my first GLP? This was some information that was told to me by multiple people (as to avoid losing muscle mass, though I am exercising and doing cardio already).

Keep in mind, I've been a fata*s my whole life, even as a child. My metabolism is just garbage and needs some help. I've lost over 60lbs+ on diet changes and cardio alone, but I haven't been able to get the rest of this off. Thanks in advance for your insight

If I were starting all of this again, I would take Semaglutide first. It’s super cheap, and to me it has no effect after being on Tirz. I would do Sema, Tirz than Reta.

I would not start different peptides at the same time. Take one to see how it works and then try another of you feel like you need it.

 

[Peptidase]

Would start with Reta. Especially with being potentially GLP-1 naive. Works great and the side effect profile is a lot less in my experience than the others. Used Tirz to start but stopped after about 5 weeks (constipation, ridiculous insomnia, anhedonia). With Reta, I’ve largely had none of those problems. And the weight loss was a lot faster with it.

 

[touringsedan]

Semaglutide first, cheapest, has the most sides (which help some with effectiveness). Tirzepatide and eventually Reta if needed. This gives you the most options of/when one stops being effective.

 

[flsailfish22]

I personally chose to start on reta. I did have some side effects, but switched to micro dosing 3 days a week those side effects are gone. 2 months in I'm only on 3mg. I take 1mg M, W, F. Sometimes I have slight food noise, but I'm ok with that. Eventually, you will have to learn to eat without extra help. Days I have food noise are also the same days I haven't had enough water and fiber. I view GLP1s as a tool and not a crutch I can't live without.

 

[miche52]

**Not Asking for Medical Advice**
**Asking for personal perspectives only**

Hi All,
For those that have been on the weight loss journey with GLP-1s, if you had to start over all over again would you go with Triz or Reta as your first GLP?

Personally, I am thinking about starting Triz first and then moving on to Reta at a later time. Someone told me to "keep my options open" in case my progress stalls on one peptide so that I have still have other options. I know each of our bodies are different and we may not have the same experience on the same peptides, but just trying to figure out a great starting point.

Additionally, how you do feel about me stacking Amino 5 1 MQ while starting my first GLP? This was some information that was told to me by multiple people (as to avoid losing muscle mass, though I am exercising and doing cardio already).

Keep in mind, I've been a fata*s my whole life, even as a child. My metabolism is just garbage and needs some help. I've lost over 60lbs+ on diet changes and cardio alone, but I haven't been able to get the rest of this off. Thanks in advance for your insight

**Not Asking for Medical Advice**
**Asking for personal perspectives only**

Hi All,
For those that have been on the weight loss journey with GLP-1s, if you had to start over all over again would you go with Triz or Reta as your first GLP?

Personally, I am thinking about starting Triz first and then moving on to Reta at a later time. Someone told me to "keep my options open" in case my progress stalls on one peptide so that I have still have other options. I know each of our bodies are different and we may not have the same experience on the same peptides, but just trying to figure out a great starting point.

Additionally, how you do feel about me stacking Amino 5 1 MQ while starting my first GLP? This was some information that was told to me by multiple people (as to avoid losing muscle mass, though I am exercising and doing cardio already).

Keep in mind, I've been a fata*s my whole life, even as a child. My metabolism is just garbage and needs some help. I've lost over 60lbs+ on diet changes and cardio alone, but I haven't been able to get the rest of this off. Thanks in advance for your insight

Sema then tirz. I lost a bit over 30 (194 to 161) pounds on sema, highest dose 1.0mg. It was slow but it came off. I went to maintenance for awhile. It gave me a chance to manage where I was. I switched to tirz 4 weeks ago currently dosing at 3.0mg. Gonna continue to microdose to get to 145 pounds. Would like to try reta but the racing heart side effect gives me pause.

 

[Ted R]

I chose Reta as well, but experienced the dreaded Resting Heart Rate increase side effect (jumped from 68 to 120), so loving Tirz now.

 

[Morbius]

I don't think this can be discussed without knowing more about your specific goals and risk tolerance and budget.

For example I chose reta as my first GLP-1, because I was interested in its allegedly superior performance... And I don't need the superior appetite suppression of sema. Food noise isn't my problem, it's more about eating too much when I DO eat.

And, reta isn't even a "real" drug yet. We take it because all the available evidence is that it's great, but imaging telling your doctor that you are taking it? Even if they are open minded they'd probably scold you for taking underground unapproved reta when sema and tirz are available and better understood.