Is the weight loss effect of retatrutide really that powerful?

[Batscout]

Seventy-three 22nd of November, Bikechick.
I'm having a TEE-SHIRT made for the B-Day occasion that will read:

" it's weird being the same age as old people "

I want one of those shirts.

 

[devlwomn91]

Im on Tirzepatide and take 1.5ml Lipo-B once/ week

I bought a bunch of Reta in a group buy last year, but have been too chicken to try it lol. Sema and tirz are being used by hundreds of thousands of people (and are "FDA approved" not that I think that's an absolute requirement for me), but reta is still only being used by a tiny fraction and the handful of heart complications reported in the trial is enough to scare me off for now. I think I'm going to have to wait another while before giving it a try for my own peace of mind.

I've been fortunate that tirz fatigue hasn't really be an issue for me, but I'm currently trying to cut way back on my absurd caffeine intake so I've definitely been feeling more run down the past few weeks.

I'm getting ready to sign up for Defy and try their Lipo-C which a lot of people have reported has helped tremendously.

. Never feel fatigue.It helps.

 

[leokitcat]

Reta just made me hungrier than Tirz even at higher doses. So I wasn’t losing or gaining because of the increased heart rate (which I could feel) and energy expenditure of Reta. In the end I think Tirz + something like Cagri low dose is a better bet

 

[GLP69]

I got full quicker on Tirz, but the Tirz exhaustion was a real issue for me. I get none of that on Reta, which has lead to me being more consistent with exercise.

 

[Sunflower]

I got full quicker on Tirz, but the Tirz exhaustion was a real issue for me. I get none of that on Reta, which has lead to me being more consistent with exercise.

I can relate to the Tirz exhaustion. What were your most recent dosing regimens for both Tirz and Reta?

 

[GLP69]

I can relate to the Tirz exhaustion. What were your most recent dosing regimens for both Tirz and Reta?

I was at 10mg on Tirz, and now I'm at 9mg Reta. I was gettting the exhaustion even with 5mg of Tirz. I stuck with it hoping it would go away, but it never did. I tried splitting, but that just made it worse honestly.

I juuust moved up to 9mg of Reta, and the satiation effect is definitely more noticeable now.

I do remember reading that sometimes it takes longer to see results with Reta than with Tirz, maybe there's something to that. I've lost a little weight still, but most of the weight I've lost was while on Tirz.

 

[Sunflower]

Your example makes me wonder if Reta might be better for people using GLP-1s for appetite regulation, insulin control, food addictions, etc. more so than weight loss. Or those that have lost most of their excess weight on Sema/ Tirz and want to slow it down while mitigating lethargy.

Other than that, I think the Tirz/Cagri is a good option if Reta doesn’t work out. There are probably lots of us who get incredible benefits from Sema/ Tirz, but are reluctant to add harsher stimulant supplements to deal with fatigue.

Over the past few months, I tried Semax, Bromantane, and fladrafinil individually and combined with no noticeable boost. Methylene blue is slightly effective so far!

 

[GLP69]

Your example makes me wonder if Reta might be better for people using GLP-1s for appetite regulation, insulin control, food addictions, etc. more so than weight loss. Or those that have lost most of their excess weight on Sema/ Tirz and want to slow it down while mitigating lethargy.

Other than that, I think the Tirz/Cagri is a good option if Reta doesn’t work out. There are probably lots of us who get incredible benefits from Sema/ Tirz, but are reluctant to add harsher stimulant supplements to deal with fatigue.

Over the past few months, I tried Semax, Bromantane, and fladrafinil individually and combined with no noticeable boost. Methylene blue is slightly effective so far!

Im ADD and have an addy script, and even that didn't help.

 

[hexagonal]

Your example makes me wonder if Reta might be better for people using GLP-1s for appetite regulation, insulin control, food addictions, etc. more so than weight loss. Or those that have lost most of their excess weight on Sema/ Tirz and want to slow it down while mitigating lethargy.

Other than that, I think the Tirz/Cagri is a good option if Reta doesn’t work out. There are probably lots of us who get incredible benefits from Sema/ Tirz, but are reluctant to add harsher stimulant supplements to deal with fatigue.

Over the past few months, I tried Semax, Bromantane, and fladrafinil individually and combined with no noticeable boost. Methylene blue is slightly effective so far!

So far studies seem to show on that on the aggregate, reta results in more weight loss than sema or tirz.

Individuals will of course vary, but I'd caution against taking individual reports over clinical trial results for the general use of reta.

 

[GimmeABreak]

Over the past few months, I tried Semax, Bromantane, and fladrafinil individually and combined with no noticeable boost. Methylene blue is slightly effective so far!

How do you dose methylene blue, I can't walk around with a blue tongue/mouth. I tried filling gell caps but it was a serious PITA and would quickly melt them. I ultimately put it to the side after a couple of tries.

 

[Sunflower]

How do you dose methylene blue, I can't walk around with a blue tongue/mouth. I tried filling gell caps but it was a serious PITA and would quickly melt them. I ultimately put it to the side after a couple of tries.

I fill a tiny shot glass with cold water, then add 10-20 drops (5-10mg) MB right over the sink. Swirl with a straw and try to bypass the teeth and tongue as much as possible! Then swish with water or mouthwash right after.

 

[GimmeABreak]

I fill a tiny shot glass with cold water, then add 10-20 drops (5-10mg) MB right over the sink. Swirl with a straw and try to bypass the teeth and tongue as much as possible! Then swish with water or mouthwash right after.

Interesting, does this method completely avoid the smurf mouth side affect or just minimize it?

 

[Sunflower]

Interesting, does this method completely avoid the smurf mouth side affect or just minimize it?

For me, it’s not noticeable if I do this before brushing teeth. I also use a tongue scraper daily, so if I take the MB first thing and get ready to leave the house a few hrs later, everything looks normal. I think the straw is the key, though it takes practice to suck the water up while almost deep throating the straw

 

[keangkong]

You're probably correct, it just didn't fit comfortably into my risk profile for now. I imagine as trials progress and use widens I will reconsider it.

Thanks to both you and Dionysos. I value both of your opinions. For now, I’ll stick with adding semaglutide to my tirzepatide, but my reason is that I should stick with what I started and not change unless a problem develops.

 

[GimmeABreak]

For me, it’s not noticeable if I do this before brushing teeth. I also use a tongue scraper daily, so if I take the MB first thing and get ready to leave the house a few hrs later, everything looks normal. I think the straw is the key, though it takes practice to suck the water up while almost deep throating the straw

Thanks, I may need to give it another try.

 

[hexagonal]

I add the MB to my core power chocolate protein drinks and it doesn't stain my teeth or tongue at all.

 

[glpfun]

Tell people the spice must flow if they question the blue teeth

 

[chmuse]

This may be a stupid question, but are we talking about the same methylene blue I use as a fish medication? I had no idea people could use it too.

 

[keangkong]

Thanks to both you and Dionysos. I value both of your opinions. For now, I’ll stick with adding semaglutide to my tirzepatide, but my reason is that I should stick with what I started and not change unless a problem develops.

The tirz/semaglutide combo didn't work out for me. I had to go to the emergency room two weeks ago for severe diarrhea likely caused by food poisoning and which probably had nothing to do with GLP-1 medications. I had passed out. While at the hospital, they did a scan of abdomen and wrote that it was full of food and it looked like I might have gastroparesis. I had noticed the feeling in my stomach that the food never left. With all of that said, I am continuing to lose weight on tirzepatide. Although it's certainly possible that I won't get to my 155 pound goal, I'm losing weight at close to 2 pounds per week and am within 19 pounds of my goal. For practical purposes, if I get to 165 and then my weight stays the same, I won't be complaining. That would result in my being 4 pounds above a normal BMI. That will get my me the overwhelming majority of the benefits of having a normal BMI. While tirzepatide is no miracle drugs - at different times I deal with different side effects - it does allow me to achieve weight loss that simply would not have occurred without it.

 

[GimmeABreak]

This may be a stupid question, but are we talking about the same methylene blue I use as a fish medication? I had no idea people could use it too.

Yes, but is supposed to be "pharmaceutical grade".