The tirz/semaglutide combo didn't work out for me. I had to go to the emergency room two weeks ago for severe diarrhea likely caused by food poisoning and which probably had nothing to do with GLP-1 medications. I had passed out. While at the hospital, they did a scan of abdomen and wrote that it was full of food and it looked like I might have gastroparesis. I had noticed the feeling in my stomach that the food never left. With all of that said, I am continuing to lose weight on tirzepatide. Although it's certainly possible that I won't get to my 155 pound goal, I'm losing weight at close to 2 pounds per week and am within 19 pounds of my goal. For practical purposes, if I get to 165 and then my weight stays the same, I won't be complaining. That would result in my being 4 pounds above a normal BMI. That will get my me the overwhelming majority of the benefits of having a normal BMI. While tirzepatide is no miracle drugs - at different times I deal with different side effects - it does allow me to achieve weight loss that simply would not have occurred without it.