Let's talk GLP1's downfall - MUSCLE LOSS

[hexagonal]

I've gotta disagree on the kettlebell thing, unfortunately. Progressive overload is the name of the game when it comes to effective resistance training, and for compound/dynamic movements like those that kettlebells are best at, most people are going to get better results with a barbell, even though it might seem scarier at first, and both have injury potential when used improperly.

You get additional stabilization from a barbell, incremental loading is easier, etc. You're much more likely to get limited by accessory muscles on kettlebell lifts, so you'll be getting the most muscle growth there, because they'll fail first - the primary muscles just aren't going to get as close to failure and as such not get as much growth stimulus.

I'd personally recommend barbells, dumbbells, cables/functional trainers, smith machines, plate/selectorized machines, etc., all as part of a routine before kettlebells.

Of course, doing what you enjoy and you personally find effective is way more important than doing what is "theoretically" best, so if kettlebells are what works for you, no hate there.

 

[Revo39564]

I lost 100 lbs in a little under 6 months and now down 142 lbs in 9 months … was 352 now 210….. lost muscle of course but don’t look like a crack head. Strength and muscle are normal for my weight … I am
Not lifting as much weight either
I had a size 52 waist ,now wear 34-36 “ …… buying large shirts instead of 4-5xl is great. The next phase is weight training to regain some muscle and see if muscle memory is real thing lol…

 

[DwightTheDelight]

I lost 100 lbs in a little under 6 months and now down 142 lbs in 9 months … was 352 now 210….. lost muscle of course but don’t look like a crack head. Strength and muscle are normal for my weight … I am
Not lifting as much weight either
I had a size 52 waist ,now wear 34-36 “ …… buying large shirts instead of 4-5xl is great. The next phase is weight training to regain some muscle and see if muscle memory is real thing lol…

Hell yeah! Good job.

I have a similar story to yours and will be entering rebuild mode here in the next couple of months.

I did do a couple DEXA scans throughout this process though. The first after the first 70lbs lost and another at 160 lbs down. Of those 90lbs lost between the scans, 1 out of every 4 lbs lost was lean mass. Probably not ideal, but I didn't think it was horrible considering I just sat at my work desk and melted for those 9 months. I'm now moving more/casually lifting and can already see a bit of muscle redeveloping. Excited for this next phase.

 

[Revo39564]

Hell yeah! Good job.

I have a similar story to yours and will be entering rebuild mode here in the next couple of months.

I did do a couple DEXA scans throughout this process though. The first after the first 70lbs lost and another at 160 lbs down. Of those 90lbs lost between the scans, 1 out of every 4 lbs lost was lean mass. Probably not ideal, but I didn't think it was horrible considering I just sat at my work desk and melted for those 9 months. I'm now moving more/ casually lifting and can already see a bit of muscle redeveloping. Excited for this next phase.

Yeah, I was thinking about getting a DEXA scan to see how much fat I have…. I was gonna lift weights for six months then have it done

 

[Revo39564]

Hell yeah! Good job.

I have a similar story to yours and will be entering rebuild mode here in the next couple of months.

I did do a couple DEXA scans throughout this process though. The first after the first 70lbs lost and another at 160 lbs down. Of those 90lbs lost between the scans, 1 out of every 4 lbs lost was lean mass. Probably not ideal, but I didn't think it was horrible considering I just sat at my work desk and melted for those 9 months. I'm now moving more/casually lifting and can already see a bit of muscle redeveloping. Excited for this next phase.

Yeah, that’s called the quarter ffm rule….. so you did perfect….

 

[nonyabizznez]

Hell yeah! Good job.

I have a similar story to yours and will be entering rebuild mode here in the next couple of months.

I did do a couple DEXA scans throughout this process though. The first after the first 70lbs lost and another at 160 lbs down. Of those 90lbs lost between the scans, 1 out of every 4 lbs lost was lean mass. Probably not ideal, but I didn't think it was horrible considering I just sat at my work desk and melted for those 9 months. I'm now moving more/casually lifting and can already see a bit of muscle redeveloping. Excited for this next phase.

Yeah but do you look like a crack head?

I was going for meth head w/o the teeth issues... Got skinny fat guy instead... I'm good with it!

 

[indolent]

Doing (5mg) of Tirz, (500mcg) SLU-PP-332, along with my TRT therapy (200mgTE), down 50lbs since Christmas with minimal fat loss. It’s tough, but you must eat, & often.

Thank you for being honest about your products' effect.

 

[TetsuNW]

I've gotta disagree on the kettlebell thing, unfortunately. Progressive overload is the name of the game when it comes to effective resistance training, and for compound/dynamic movements like those that kettlebells are best at, most people are going to get better results with a barbell, even though it might seem scarier at first, and both have injury potential when used improperly.

You get additional stabilization from a barbell, incremental loading is easier, etc. You're much more likely to get limited by accessory muscles on kettlebell lifts, so you'll be getting the most muscle growth there, because they'll fail first - the primary muscles just aren't going to get as close to failure and as such not get as much growth stimulus.

I'd personally recommend barbells, dumbbells, cables/functional trainers, smith machines, plate/selectorized machines, etc., all as part of a routine before kettlebells.

Of course, doing what you enjoy and you personally find effective is way more important than doing what is "theoretically" best, so if kettlebells are what works for you, no hate there.

Well you're right about a few things. Progressive overload is the name of the game and for muscle growth specifically a barbell is superior. Where you're a bit off the mark is the progression with kettlebells, kbs are going to be mostly about volume. While you can find smaller kbs in 2kg increments micro plate options just don't work well, and magnets don't seem safe to me. It really comes down to volume, mostly increasing reps/sets/ladders or decreasing rest time. Of course you make jumps in KBs too, it's argued the larger jumps make you stronger, idk how I feel about that one though lol.

I want to also make it clear that KB training does build muscle. It's not an optimal implement if your goal is body building type muscle growth. If you want more strength and cardio mixed in, with less chance of injury as the weights are smaller, then KBs should be considered.

If you want to train in a gym you'll have an easier time finding free weights and machines. If you want to train at home in a small space then KBs. From a cost perspective a 12-16-20 or 16-20-24 set of kbs is about the same a single barbell.

Give KB training a go. I was slow to get KB training, it took until I had to move into a studio while my house was being remodeled. I trained on a single 4x6 horse mat I pulled out of storage. Even after the initial ramping up stage the pain free training, mobility, strength, easy recovery and energy I had blew all my years of barbell training out of the water.

I strongly encourage anyone reading all of this nerding out to resistance train. Added on top of the choice you already made for yourself with glp-1s, you will be giving yourself and ypur loved ones the best possible gift of your best self and a longer healthier life.

 

[Revo39564]

Yeah but do you look like a crack head?

I was going for meth head w/o the teeth issues... Got skinny fat guy instead... I'm good with it!

Skinny guy with lots of extra skin here lol

 

[ruisenor]

So you've lost an enormous amount of weight. Have you noticed how much muscle mass you've lost?
Arguably the biggest drawback to GLP-1's is the loss of muscle mass. Many in the healthcare industry are espousing an early death due to GLP-1's rapid weight loss going hand in hand with rapid muscle loss. Older GLP-1 patients losing so much muscle mass they cannot gain back and will no longer be able to support their own body weight as they age.
Let's talk about gaining this muscle mass back. We have some great tools at our disposal: CJC-1295, Ipamorelin, Tesamorelin, GH, ABS.
What are you trying and what have been the results?

Reta ate my ass. My glutes basically evaporated. 3 months in I increased protein intake and strength training and have gained some muscle mass back, but still have stretch marks on my cheeks..

 

[keangkong]

its really impossible to burn fat and gain muscle at the same time or bodybuilders would have figured it out. bodybuilders are either in gain muscle and fat mode or reduce muscle and fat mode.

you can't change the laws of physics captain.

People often do burn fat and gain muscle at the same time. Whether you can do so depends on the time of shape you're in. People regularly did so while on the TV show the Biggest Loser. Of course, the folks on the show had professional coaches and didn't have any other employment at the time. If you have gone to the gym a few times per week for lifting, losing fat while gaining muscle will be quite hard. If, on the other hand, you've been a couch potato, it becomes quite possible to gain muscle while losing weight. Also, if you start taking steroids (something I don't recommend) while you're losing weight, your ability to lose weight while gaining muscle goes up.

What raw-oyster-eater wrote generally does apply to body builders. My understanding (and I'm not a body builder) is that body builders are always either increasing their weight or reducing their weight. They have to frequently reduce weight so they don't get too fat. While reducing, they exercise to maintain muscle. While gaining weight, muscle size will increase far more with exercise than if a person was exercising while in a calorie deficit or while eating only enough calories to make up what one burns during the day.

 

[Calm Logic]

Older GLP-1 patients losing so much muscle mass they cannot gain back and will no longer be able to support their own body weight as they age.

Oh please. They could always gain the muscle back, just like they do after the trauma of total knee replacement. These healthcare podcasters just need to say something to get attention.

According to Dr. Seed (the peptide guru who is very buff for his age), there is nothing about GLP-1s that makes us lose muscle more than just the effects of dieting. And we have known for 100+ years about muscle loss from dieting.

Dr. Seed is all about cell signaling (to the point he sounds like George in Seinfeld: “Cause it's signals, Jerry, it's signals!”). He says increasing protein intake and doing strength training helps signal to the body to eat fat, not muscle. And 80+ year olds can easily do resistance training:

 

[rkl123]

Oh please. They could always gain the muscle back, just like they do after the trauma of total knee replacement. These healthcare podcasters just need to say something to get attention.

According to Dr. Seed (the peptide guru who is very buff for his age), there is nothing about GLP-1s that makes us lose muscle more than just the effects of dieting. And we have known for 100+ years about muscle loss from dieting.

Dr. Seed is all about cell signaling (to the point he sounds like George in Seinfeld: “Cause it's signals, Jerry, it's signals!”). He says increasing protein intake and doing strength training helps signal to the body to eat fat, not muscle. And 80+ year olds can easily do resistance training:

There’s been some discussion about glucagon itself leading to lower free amino acids. Folks speculate it would make it harder to gain muscle and raise protein requirements. But we don’t really know.

 

[jasonlovespeptides]

Lost 205 lbs in 14 months. I’m sure I lost some muscle but don’t give a damn. I’m skinny AF. I look great. My bloodwork is amazing. I’m successfully maintaining my lowest weight. Benefits outweigh any muscle loss negatives. If I wanted slow and steady weightloss I would have spent less money and gone to WW to lose a few lbs a month

 

[tul9033]

Oh please. They could always gain the muscle back, just like they do after the trauma of total knee replacement. These healthcare podcasters just need to say something to get attention.

According to Dr. Seed (the peptide guru who is very buff for his age), there is nothing about GLP-1s that makes us lose muscle more than just the effects of dieting. And we have known for 100+ years about muscle loss from dieting.

Dr. Seed is all about cell signaling (to the point he sounds like George in Seinfeld: “Cause it's signals, Jerry, it's signals!”). He says increasing protein intake and doing strength training helps signal to the body to eat fat, not muscle. And 80+ year olds can easily do resistance training:

It's cause and effect. Not that the GLP-1's are directly responsible for muscle loss other than rapid weight loss and the associated muscle loss.

 

[Calm Logic]

There’s been some discussion about glucagon itself leading to lower free amino acids. Folks speculate it would make it harder to gain muscle and raise protein requirements. But we don’t really know.

And there's speculation that the GLP-1s help preserve muscle during weight loss, such as by reducing inflammation and insulin resistance.

 

[Calm Logic]

It's cause and effect. Not that the GLP-1's are directly responsible for muscle loss other than rapid weight loss and the associated muscle loss.

In that case, I say we start having virtual pizza parties

I do wonder how internalized fat stigma may contribute to people losing weight too fast (by upping the dose to accelerate reaching an arbitrary/cultural standard). But the fear of sagging skin slows me down more than anything, more so than potential muscle loss.

 

[tul9033]

In that case, I say we start having virtual pizza parties

I do wonder how internalized fat stigma may contribute to people losing weight too fast (by upping the dose to accelerate reaching an arbitrary/cultural standard). But the fear of sagging skin slows me down more than anything, more so than potential muscle loss.

Oh for sure, obesity is as much of a mental illness as anything.
Luckily, I've never really struggled with my weight. I mainly got into this for my family members. I did and do take low doses of Tirz mainly for the inflammation effects. I was about 10-15 #'s over my goal weight last year and got up to 3 mg of Tirz. It was shocking how I had to force myself to eat. Others in my family have lost over 40 #'s and the bat wing arms are real! I do notice the loss of muscle mass in the high # losers.