Orforglipron: The next big thing?

[vewdew34]

Does anyone sell orforglipron?

Yes SSA got it on the new list.

 

[Blitziod]

Novo Nordisk is working on a pill form of Semaglutide using their "SNAC" technology. The recent news about Amycretin was also encouraging, although still in early trials. I agree that pills will be the preferred method of administration for most people. This would mean easier production, distribution and storage. Unfortunately, I am less optimistic that Novo or Evil Lilly would charge any less for the pills. We need competition from more companies, not just a different form of the medication.

If the drug costs less to make , store , transport and distribute the price will be lower. More so if there are multiple oral drugs on the market. In fact they may be able to make MORE money charging less. The vast majority of Americans aren’t able to afford the current price structure. 50% profit levels on 10 sales are a lot better than 200% profit levels on 1.


There are 104 million obese Americans. And 86 million overweight. Around 15 million are on glp 1 drugs ( legit scripts ) currently. The drug companies could sell a LOT more at a lower price point. And they are going to have to in a few years when patents expire.

 

[keangkong]

If the drug costs less to make , store , transport and distribute the price will be lower. More so if there are multiple oral drugs on the market. In fact they may be able to make MORE money charging less. The vast majority of Americans aren’t able to afford the current price structure. 50% profit levels on 10 sales are a lot better than 200% profit levels on 1.


There are 104 million obese Americans. And 86 million overweight. Around 15 million are on glp 1 drugs ( legit scripts ) currently. The drug companies could sell a LOT more at a lower price point. And they are going to have to in a few years when patents expire.

Agreed. Over time the prices will fall. Granted I’m not paying much now thanks to Chinese vendors.

 

[GLP1Pharmacist]

Refrigerator needs and transport is huge for the companies and wholesalers, oral tabs will be cheaper all around.

 

[randompersonrandom]

No thanks to a pill form of anything. I have to think about my tirz once a week for about five minutes, and then I get to just go about my business. If I could stick my thyroid medicine, my vitamins, and all my other meds into a syringe, do it once a week, and spend the whole rest of the week never trying to remember to go swallow a pill, I'd be thrilled.

 

[keangkong]

No thanks to a pill form of anything. I have to think about my tirz once a week for about five minutes, and then I get to just go about my business. If I could stick my thyroid medicine, my vitamins, and all my other meds into a syringe, do it once a week, and spend the whole rest of the week never trying to remember to go swallow a pill, I'd be thrilled.

I'm not sure I actually prefer an injection to pills, however, I don't mind injecting myself enough to tolerate worse results with pills. I do realize that large numbers of folks do have problems with injecting themselves. I though I had a problem with injecting myself too as I spent about an hour preparing to inject myself for the first time. Then I injected myself. It was actually rather funny; after all that worry, it turned out to be nothing (for me).

 

[randompersonrandom]

I though I had a problem with injecting myself too as I spent about an hour preparing to inject myself for the first time. Then I injected myself. It was actually rather funny; after all that worry, it turned out to be nothing (for me).

GIRL SAME! (or boy same) SO SAME! I thought it was gonna hurt, gonna be scary, gonna be complicated, and then "Oh. Now I'm done? for a WEEK???"

 

[mlke6]

I had nightmares about stabbing myself after my first injection. I kinda like pinning myself now. I also had nightmares when I first got contacts. I still don't really like putting those in and taking them out.

 

[geoguy78]

Yes SSA got it on the new list.

$55 a month at 12mg dose. Not too shabby honestly

 

[byefatlicia]

Yes SSA got it on the new list.

I noticed they have Tirz in pill form. Anyone have info on this? is it effective? Has anyone given it to their rats yet?

 

[geoguy78]

I noticed they have Tirz in pill form. Anyone have info on this? is it effective? Has anyone given it to their rats yet?

Oral tirz is a scam. Stomach acid destroys peptides. NN has an oral formulation of semaglutide but it requires a special formulation and very high dose to make it through the stomach intact

 

[peptideusername]

I noticed they have Tirz in pill form. Anyone have info on this? is it effective? Has anyone given it to their rats yet?

They have tirz pills... but do you know who isn't offering tirz pills?

Eli Lilly

There's a good reason why, and it's not because none of their scientists thought of it.

 

[mlke6]

I noticed they have Tirz in pill form. Anyone have info on this? is it effective? Has anyone given it to their rats yet?

I feel it would be such a silly thing to even try. Tirz is once a week and works incredibly well.

 

[byefatlicia]

I feel it would be such a silly thing to even try. Tirz is once a week and works incredibly well.

I totally agree. But I have a needlephobic friend that i'm thinking about. Orfor is only a GLP-1 while Tirz is dual with GIP was my thinking. But so far, the consensus is that a Tirz in pill form won't work.

 

[mlke6]

I totally agree. But I have a needlephobic friend that i'm thinking about. Orfor is only a GLP-1 while Tirz is dual with GIP was my thinking. But so far, the consensus is that a Tirz in pill form won't work.

If your friend is brave enough there is always being a test subject for bioglutide.

 

[pavlovs]

Kimera has it now.

 

[desinr-gal]

I thought this might be useful for discussion. Although since these are different studies with varying timelines its not exactly as it looks. The depth should be % weight lost of the time specified above each section. This I took from a sub reddit, posted by a mod who I believe is associated with Pharma.

 

[MsGizmo]

Oral tirz is a scam. Stomach acid destroys peptides. NN has an oral formulation of semaglutide but it requires a special formulation and very high dose to make it through the stomach intact

Well they could always try and make a GLP1 suppository. ROFL.

 

[desinr-gal]

I estimated where each of the leaders weight loss percentage would have gotten to, if extended to 48 wks like the reta study, and drew lines across for comparison. The only ones that come close to Reta are the Cagri-sema and the Mazdutide..

 

[nonyabizznez]

I estimated where each of the leaders fat loss percentage would have gotten to, if extended to 48 wks like the reta study, and drew lines across for comparison. The only ones that come close to Reta are the Cagri-sema and the Mazdutide..

Where's Tirz? 🤔

 

[desinr-gal]

Where's Tirz? 🤔

I asked that too, she said these are the latest compounds in studies, since Tirze and sema already have been approved, they weren't included.

 

[keangkong]

I estimated where each of the leaders fat loss percentage would have gotten to, if extended to 48 wks like the reta study, and drew lines across for comparison. The only ones that come close to Reta are the Cagri-sema and the Mazdutide..

Thanks. It seems like the best bet for next generation weight loss drugs really got now is Reta. For FDA approved stuff, tirzepatide is the clear winner for most folks. I have had to stop because I’m having liver problems. While the doctor thinks reta is probably not the cause, I have to stay off reta until my liver results come back to normal.

 

[desinr-gal]

Motors?

 

[keangkong]

Motors?

I edited my post. I don't how I would have written tirzepatide as "Motors," but I did. It's kind of like how Binh from Amo refers to tirzepatide as "L."

 

[desinr-gal]

I'm sorry to hear about that, and I'm thinking we should all get tested regularly. I havent in a year.

 

[geoguy78]

View attachment 8850
I thought this might be useful for discussion. Although since these are different studies with varying timelines its not exactly as it looks. The depth should be % weight lost of the time specified above each section. This I took from a sub reddit, posted by a mod who I believe is associated with Pharma.

Maz is in the wrong spot, it's a GLP-1 + GCG Dual RA like Survo.

 

[CherBear]

No thanks to a pill form of anything. I have to think about my tirz once a week for about five minutes, and then I get to just go about my business. If I could stick my thyroid medicine, my vitamins, and all my other meds into a syringe, do it once a week, and spend the whole rest of the week never trying to remember to go swallow a pill, I'd be thrilled.

Direct opposite here. I can easily forget to take a shot once a week and I often find myself doing exactly that. I pin sema on Saturday night, tirz on Sunday. The number of times I've been halfway to sleep and had to jump up to take my shot is pretty high. Sometimes I forget entirely and take it the next day when I remember.

On the flip side, I take my pills every day. They're a habit; I don't easily forget them. Most of my pill case is supplements I choose to take (collagen, iron, vitamins, fiber, etc) and the rest is allergy meds, so I'm pretty motivated to remember them.

I'd never choose an injectable weekly drug over a daily tablet for maintenance. Injectables are a no-brainer right now for active weight loss since they're so much stronger, but I'm looking forward to one day not needing them and letting my subcutaneous fat take a break.