Orforglipron: The next big thing?
- Thread starter Derby
- Start date
Calm Logic
GLP-1 Specialist
I doubt there are such studies yet, but it should be fine.
Obesity specialists have been adding metformin occasionally for some people already on a GLP, like when someone on sema or tirz wants a boost but can't raise the dose yet due to the dosing schedule.
Obesity specialists have been adding metformin occasionally for some people already on a GLP, like when someone on sema or tirz wants a boost but can't raise the dose yet due to the dosing schedule.
Last edited:
Calm Logic
GLP-1 Specialist
By the way, brand-name Jardiance is available from India.
Personally, I don't see the need for having Jardiance or metformin along with a GLP, since a GLP is much stronger. (My internist wanted me to increase the dose for tirz even weekly, if necessary.)
OTOH, metformin increases the body's natural production of GLP-1. So it may be good while on a strict dosing schedule. Like people tend to feel hungrier on day five of a weekly dose of tirz.
Personally, I don't see the need for having Jardiance or metformin along with a GLP, since a GLP is much stronger. (My internist wanted me to increase the dose for tirz even weekly, if necessary.)
OTOH, metformin increases the body's natural production of GLP-1. So it may be good while on a strict dosing schedule. Like people tend to feel hungrier on day five of a weekly dose of tirz.
Last edited:
byefatlicia
GLP-1 Enthusiast
Have you seen anything on skyrizy?
Calm Logic
GLP-1 Specialist
Not really. The one reputuble-looking seller on IndiaMart sells it for over $1,000 USD, which is still cheap compared to the price at GoodRx. And according to Google Gemini, it is still under a patent in India.
byefatlicia
GLP-1 Enthusiast
Okay thanks🙂 the brand name goes for 19k :0
Calm Logic
GLP-1 Specialist
Yeah, I just noticed that and included the link to GoodRx. Insane.
Calm Logic
GLP-1 Specialist
From an article on polypharmacy:
Why Do GLP-1 Drugs Stop Working, and What to Do About It?
Everybody has a set point, and every weight loss intervention eventually leads to a plateau, so it helps to have a variety of tools to support patients.
www.medscape.com
"You don't see this in the studies, which are focused on just one drug, but many of our patients are on combination therapy. They're on a GLP-1 drug plus phentermine/topiramate plus metformin, and more. They're usually on three, four, five drugs, similar to what we would see with resistant hypertension."
Last edited:
Calm Logic
GLP-1 Specialist
This is only true if 10% weight loss is considered "considerable " efficacy, I guess
Calm Logic
GLP-1 Specialist
Yes, to get good efficacy, one would ideally switch from orfo to tirz (or reta) at some point. At 12 weeks, orfo is almost similar to tirz in effect. As time goes on, the average differences become painfully obvious, according to the studies. This is similar in idea to switching from sema to tirz.
Last edited:
Thank you for sharing!!From an article on polypharmacy:
Why Do GLP-1 Drugs Stop Working, and What to Do About It?
Everybody has a set point, and every weight loss intervention eventually leads to a plateau, so it helps to have a variety of tools to support patients.
"You don't see this in the studies, which are focused on just one drug, but many of our patients are on combination therapy. They're on a GLP-1 drug plus phentermine/topiramate plus metformin, and more. They're usually on three, four, five drugs, similar to what we would see with resistant hypertension."
