Orforglipron: The next big thing?

[druell235]

Have any of the studies covered how Orforglipron interacts with metformin. I am still on metformin and don't want to quit when I start researching this.

 

[Calm Logic]

I doubt there are such studies yet, but it should be fine.

Obesity specialists have been adding metformin occasionally for some people already on a GLP, like when someone on sema or tirz wants a boost but can't raise the dose yet due to the dosing schedule.

 

[Calm Logic]

By the way, brand-name Jardiance is available from India.

Personally, I don't see the need for having Jardiance or metformin along with a GLP, since a GLP is much stronger. (My internist wanted me to increase the dose for tirz even weekly, if necessary.)

OTOH, metformin increases the body's natural production of GLP-1. So it may be good while on a strict dosing schedule. Like people tend to feel hungrier on day five of a weekly dose of tirz.

 

[byefatlicia]

By the way, brand-name Jardiance is available from India. But I personally don't see the need for having Jardiance or metformin along with a GLP, since a GLP is much stronger.

Have you seen anything on skyrizy?

 

[Calm Logic]

Have you seen anything on skyrizy?

Not really. The one reputuble-looking seller on IndiaMart sells it for over $1,000 USD, which is still cheap compared to the price at GoodRx. And according to Google Gemini, it is still under a patent in India.

 

[byefatlicia]

Not really. The one reputuble-looking seller on IndiaMart sells it for over $1,000.

Okay thanks🙂 the brand name goes for 19k :0

 

[Calm Logic]

Yeah, I just noticed that and included the link to GoodRx. Insane.