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Just posted on bookface:
QSC Retatrutide
- Thread starter ZippityDooDah
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molligirl7557
New Member
Very tempting but doing well on Tirz why change?
I have a low dose I’ve incorporated from a domestic source and so far so good. Waiting on QSC to have available so I can order
Someone I talk with in another forum (he might be here but has different u/n everywhere so idk) is using it for several months now, and is in touch with a couple others who are as well. He’s stacking with tirz, so results may be nonspecific.
Overall, he feels a stronger weight loss effect than tirz alone, a noticeable difference. The other individuals say the same. He pointed out that for him, the appetite suppression was greatest on sema, compared to tirz, or tirz + reta. But he feels this trade off is worth it because of other increased positive effects. He buys from overseas and is stocking up, as he feels the price is really going to go up, especially when more studies back it up. I’m not ready to put out the $$ because tirz is working so well for me rn. I also would like to see a COA, which his vendor doesn’t have.
Do you have a resource on Reta's dosing protocol? I'm guessing the pep calc for reconstitution; but curios to learn how the dosing goes.
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I think the trial information is what most people are using as a starting point: https://www.nejm.org/doi/full/10.1056/NEJMoa2301972
Thank you!
Pinsandneedles
New Member
I’ve been stalled since June on tirzepatide. Debating if I should give reta a try. I’m still hesitant though.
Ya'll inspired me to try some reta. Ordered this past Monday from Alisa. I stated CN if no USA reta, she charged me CN price and shipping. The next day I received a USPS email about inbound shipment from Chino, CA. Package arrived today and it is the reta.
Plan to stack with tirz.
Plan to stack with tirz.
Jovestar
New Member
Amazing turnaround! I also ordered some Reta for the 1st time on Monday, but from elsewhere, and I’m sure it will be weeks before it arrives. I’m definitely interested if you are willing to share the stack doses you’ll be researching: mg/frequency Tirz vs. Reta.
Will do. Not sure how I'll stack yet. I'm currently on 5mg tirz every five days. Food noise is fairly low. My initial thought is to start reta at 2mg about three days after my tirz dose. Alternate tirz/reta every 3 days and see how I feel...
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What you’ve described is really similar to the stacking protocols I’ve seen most ppl using. When I get mine I’ll be doing the same. Rn I’m at 7mg tirz/5 days. I may try 1mg of reta just to see how that works first. I guess I want to go slow only because of what happened with my friend I referenced..he’s been stacking reta with tirz now for more than 3 months and had been on 10mg of tirz alone prior to adding the reta. But he started with 2mg of reta with the 10mg of tirz, and after a few days he just thought he needed more reta because he didn’t notice it. So he added 2mg more. He was very sick for 2 days straight, missed work etc. He said it was a stupid mistake not taking it slowly when stacking, and not factoring in the half-life of the reta. So just thought I’d mention his experience ymmv!
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Thanks for the feedback. I agree that low, slow, and adjust as needed is the way to go. Like you, may start at 1 mg reta four days after my tirz dose and see. I plan to do a bit more research before I set my schedule; although, this is kinda unchartered territory. Will post updates.
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As an update, have taken two doses of QSC retatrutide, 2mg each about 3 days after my 5mg tirz dose. Honestly, I don't feel any additional food noise suppression or other benefit. Will continue to take and titrate.
However, I saw a reddit thread today that made me doubt the QSC retatrutide effectiveness. I know QSC had an issue with reta some time ago but this post had me doubting. Anyone else try the QSC retatrutide?
However, I saw a reddit thread today that made me doubt the QSC retatrutide effectiveness. I know QSC had an issue with reta some time ago but this post had me doubting. Anyone else try the QSC retatrutide?
You likely won't feel additional food noise suppression with Reta, at least not until you hit much higher doses, because it doesn't hit that receptor as hard. It seems to go Sema > Tirz > Reta for appetite suppression, tho it will still slow gastric emptying about the same as Tirz. I'm hungrier on Reta and at first I was suspicious about that, but... I'm still losing weight.
Reta works primarily by increasing metabolic rate / energy expenditure, the GLP1/GIP agonism is much lighter. So I think a large part of the folks who are dissatisfied are coming from a GLP1 inhibitor to low doses of Reta and expecting to revive the feeling they got the first month on Tirz. That just isn't what I'm experiencing at all, and that's just fine. The scale is my guide and the scale is happy.
Thanks for the information, TessaM. Good feedback. What you say makes sense, reta being different and to adjust expectations until higher doses. The scale guide for me is pointing in the right direction, too. I can't complain. So, I will continue on my path and titrate up slowly, or as needed.
Mounjamen
New Member
Yesterday, I read a study in which a professor wrote that different medications affect people differently and, especially at too high a dosage, can cause side effects such as mood swings, increased heart rate, and even arrhythmias. This led me to think of the following solution to the problem:
if 5 mg does not provide the sufficient effect, to administer a second injection of 5 mg? If this would double the effect, I would also try this with Retatrudite or Tirzepatide. Then I could order the correct dosage of 5 or 10 mg injections in the future. Is this possible?
if 5 mg does not provide the sufficient effect, to administer a second injection of 5 mg? If this would double the effect, I would also try this with Retatrudite or Tirzepatide. Then I could order the correct dosage of 5 or 10 mg injections in the future. Is this possible?
CiciZig69
GLP-1 Enthusiast
I just read elsewhere combing reta with tirz is not healthy due to muscle loss and heart palpitations to start.
Could you share your link?
dionysos
GLP-1 Specialist
petey neither of those doses are considered to be "therapeutic", and they are unlikely to suppress food noise or appetite.
For me, as an example, 7-10mg of Tirzepatide was needed to equal the supression effects of 2.5mg of Semaglutide. I've no dog in the QSC hunt but I don't think your experience at low doses is sufficient to cast doubt of their product.
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Thanks for your timely feedback, dionysos. That comment you referenced was 7 months ago, so lots have changed since then.
Since your concern appears to be more about QSC than me as a person, let me address that point. Which is that I agree with your conclusion. My 7-month old comment completely fails to cast doubt on QSC's reputation. However, bismirching QSC's reputation was not my intention back then. If it was, I'm sure I could cite a few compelling examples. Honestly, my 7-month old comment was selfish in nature, it was about me, not QSC. It was about my self doubt having just started stacking Reta with Tirz and reading a post related to QSC's Tirz. As a result, I posed the question with my comment. The summary feedback back then, which you touched upon, was that it was too early to tell due to the low initial dose I was on at the time. Made sense to me, I accepted that explanation and moved on. QSC's product quality, or lack of, did not enter my mind again. Until you bring it up 7-months later.
No dog in the QSC hunt? Not so sure about that. Just saying.
dionysos
GLP-1 Specialist
I'm sorry that my comment sounded personal, or biased. It was not intended to be either of those things.
Perhaps commenting on an old thread made it seem somehow pointed? Again, my apology; I didn't even notice the posting date.
I am actively engaged in an attempt to understand the differences in appetite suppression vs side effects vs dosage of the three primary GLP-1s and how I can best use them to meet my goals. The potency of each vendors products is relevant, of course, as is the very subjective nature of each individual's reporting. Those two factors alone make reaching conclusions a challenge for me - that, my old age, and my diminishing brainpower!
QSC is of very little consequence to me, and is of interest mainly because it is something of a known quantity in this new-to-me forum. I did impulsively buy 4 vials of the recent QSC Group Buy when offered to me. The amount of money was trivial, I got to meet two members of this forum, and it seemed like a fun learning experience - like going to the fairgrounds for lunch and betting on a horse. Bizzarely perhaps, I don't even need the Tirzepatide I bought 😄
You CAN justly accuse me of bias when it comes to AmoPeptide, which I purchased before my QSC fling. There is a very new, untried vendor that I researched, compared, and evaluated in my newbie way. Then I invested in AmoPeptide by purchasing a kit of Retatrutide, also a new and relatively untried entity.
I'm Biased and Invested in both of those things. Fire away peteyb !
Perhaps commenting on an old thread made it seem somehow pointed? Again, my apology; I didn't even notice the posting date.
I am actively engaged in an attempt to understand the differences in appetite suppression vs side effects vs dosage of the three primary GLP-1s and how I can best use them to meet my goals. The potency of each vendors products is relevant, of course, as is the very subjective nature of each individual's reporting. Those two factors alone make reaching conclusions a challenge for me - that, my old age, and my diminishing brainpower!
QSC is of very little consequence to me, and is of interest mainly because it is something of a known quantity in this new-to-me forum. I did impulsively buy 4 vials of the recent QSC Group Buy when offered to me. The amount of money was trivial, I got to meet two members of this forum, and it seemed like a fun learning experience - like going to the fairgrounds for lunch and betting on a horse. Bizzarely perhaps, I don't even need the Tirzepatide I bought 😄
You CAN justly accuse me of bias when it comes to AmoPeptide, which I purchased before my QSC fling. There is a very new, untried vendor that I researched, compared, and evaluated in my newbie way. Then I invested in AmoPeptide by purchasing a kit of Retatrutide, also a new and relatively untried entity.
I'm Biased and Invested in both of those things. Fire away peteyb !
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Hi Dionysos. No worries. Thanks for your reply and apology. I apologize if I went a bit overboard in my response. That closing comment of "just saying" seems to irk me when used, a pet peeve if you will. Especially by people of a certain generation. That comment caused me to question your age and after reading your other forum comments, I was surprised to learn that we appear to be close in age. Glad to know there are people on these forums who recall Captain Kangaroo and Mr. Green Jeans. I was also relieved that you're not a Chinese troll account, which happens here on occasion.
I have no issues with anyone having a bias, provided the person does not have an undisclosed financial interest driving that bias. I've seen AmoPeptides mentioned here and on Discord, but haven't checked them out. I'll take a look at their website though, if I can find it. I do miss ordering form XCE's website.
As for QCS, many people on Discord and Peppy's view QSC negatively. For many reasons I gather, but mostly I think due to poor customer service. Personally, I have not had any glp1 product or service issues with QSC. I do buy from QSC on occasion.
I will say that since xce ceased, I've been disappointed in speculating with new Chinese vendors, trying to find that next XCE (mainly due to non-glp product quality when tested and the resulting poor response). These disappointing experiences has led me to appreciate QSC more than in the past. QSC seems to attempt to improve by sending products to Jano, testing before releasing the product for purchase. I can't verify QSC follows that practice, but they do regularly pay for and release Jano test results on their own. As you probably know, most Chinese vendors won't to that. Also, unlike these new vendors, QSC has a historical testing track record with PTDS, similar to XCE. Not perfect, but far from consistently awful. Reminds me of the "the devil you know" euphemism.
It may be possible that I now have a QSC bias.
Although researching new vendors is exciting, I intend to rely on trusted group buys going forward, with custom batches that include testing, for my product needs. At least until more reliable vendors are found.
Not sure of your goals, but to me Tirz has been my main glp1 for weight loss for some time. I've had more success than with sema. Stacking with Reta is now starting to pay off I believe. I also have some of the other newer glp1s but I have yet to research and develop a plan to use them.
Anyway, I look forward to reading more of your posts, whether about your goals, AmoPeptide or this new vendor you've found.
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dionysos
GLP-1 Specialist
AmoPeptide certainly is starting off in a strong way. Having bought the mini-GB-QSC Tirz just after purchasing a full kit of Reta from AmoPeptide, I’ll reluctantly give their Tirz sale a miss.
Mam, I likely ALREADY HAVE enough peptides to last till this time NEXT YEAR 😳
Nada Hoarder, really, I can stop anytime, anytime!
Mam, I likely ALREADY HAVE enough peptides to last till this time NEXT YEAR 😳
Nada Hoarder, really, I can stop anytime, anytime!
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MrsRoper_1977
GLP-1 Specialist
Hey now, can we remain anonymous here?!😝
You’re welcome. So you bought from amopeptides but haven’t researched them yet? I’ve seen them around awhile but rarely hear them mentioned.
This GB we did will be my first experience with QSC. And I did my first overseas purchase last week for Cagri with Nantong Guangyuan’s GB. I decided to go for it since I could use Alibaba to pay. I am not interested in bitcoin.
I too have a nice stockpile. It certainly doesn’t hurt to be prepared.😃
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MrsRoper_1977
GLP-1 Specialist
If you can edit it I would appreciate it. If not, oh well.
I’m going to post again with a question about my research.
dionysos
GLP-1 Specialist
Lots of interesting things to unpack here, MrsRoper:
potential heart problems, inflammation reduction by Tirz, stacking of Sema/Tirz, stacking Reta/Tirz
First regarding potential heart problems:
NEJM June 23, 2023. Phase 2-Trial: Retatrutide fror Obesity
" The heart rate increased with retatrutide treatment in a dose-dependent manner...
the increases were similar to those reported for GLP-1 receptor agonists.33 "
"Reported cardiac arrhythmias were mild to moderate in severity with the exception of one
severe adverse event (prolonged QT syndrome) in a participant treated with ondansetron "
Ondansetron (Zofran) is known to cause prolonged QT syndrome on its own.
It seems to me the study does not suggest Retatrutide causes QT prolongation or increases its liklihood.
Further, this study points out that the temporary heart rate increases noted were similar to those found
in Semaglutide and Tirzepatide studies.
It seems to me that Retatrutide has a risk profile that is no better, and no worse than Semaglutide or Tirzepatide.
As someone with atrial fibrillation that was successfully treated with ablation surgery, drug therapy and a pacemaker
I would use this drug. I do, in fact PLAN TO USE Retatrutide.
PART TWO To Follow Later...
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MrsRoper_1977
GLP-1 Specialist
Thank you for part one. In the meantime let me provide more to unpack.😂
Oh just to clarify, I didn’t stack sema and tirz. I started the sema one week after my last dose of Mounjaro (tirz).
Now, in addition to my current stack of Reta (now 4mg) and tirz 5mg 1x week, I take 0.125mcg of tesofensine (which can also raise heart rate). I do check my rate from time to time and it’s WNL. With this stack and I do PSMF (protein sparring modified fast) 3 days a week and the weight is melting off. Thus what I’m doing is working. I’m just trying to decide if I should stop Tirz and just continue titrating Reta. Just hoping I still get the anti-inflammatory benefits.😅. If you’ve read all of this, thank you.
lagomorph
New Member
How do you like tesofensine? I was thinking of trying it in addition to Reta. I've read some people really like it but it also seems to cause insomnia for a significant amount of users. And then some people report no effects at all but IMO that is probably a vendor issue and it's not really tesofensine.
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Understanding and Managing Sleepiness with Retatrutide
Why Retatrutide Might Cause Sleepiness:- Central Nervous System Effects:Retatrutide, as a GLP-1 receptor agonist, acts on the central nervous system. This can influence neurotransmitter balance, potentially leading to feelings of drowsiness.
- Blood Sugar Levels:This medication helps lower blood sugar by increasing insulin secretion and decreasing glucagon secretion. Sometimes, these changes can lead to lower blood sugar levels, which might cause fatigue and sleepiness.
- Delayed Gastric Emptying:By delaying gastric emptying, Retatrutide can help with weight loss, but it might also cause gastrointestinal discomfort and fatigue.
- Weight Loss and Energy Balance:Rapid weight loss can cause your body to adjust its energy balance and metabolism, leading to feelings of tiredness as your body adapts.
- Specific Drug Effects:As a novel agent targeting multiple receptors (GLP-1, GIP, and glucagon), Retatrutide's multifaceted actions may contribute to sleepiness.
- Cumulative Side Effects:Other side effects such as nausea, vomiting, and headaches may indirectly contribute to feelings of drowsiness.
- Moderate Exercise:Engage in moderate physical activity daily, such as walking or light exercises, to boost your energy levels.
- Stay Hydrated:Drink plenty of water throughout the day to prevent dehydration, which can contribute to fatigue.
Whether it's drowsiness or insomnia, I hope you can consider it carefully and be prepared to deal with it and mentally prepare yourself before you try it.
MrsRoper_1977
GLP-1 Specialist
I like it. I’ve been on it about 6 weeks but take a micro dose of 0.125 mcg. I take it early, like 5-7 am, to avoid sleeping issues.
MrsRoper_1977
GLP-1 Specialist
Update: I have decided to NOT stack tirz and Reta any longer on my RS. Just going to titrate up on Reta and continue with the Tesofensine. Actually curious to see how RS does with the Reta without the Tirz.
dionysos
GLP-1 Specialist
Thanks for the interesting and relevant update. A recent convert to Tirzepatide for my RA, I’ve acquired Retatrutide but not yet used it. My original concept was that Reta was the logical next step when Tirz ceased to provide appetite relief/weight loss; this seemed likely as it had occurred with Sema at about the one year mark.
Optionally I thought, stacking Reta with Tirz could extend my Tirz reserves and provide continued weight loss while avoiding the higher dosages/potential side effects of either one.
Where I am now: at 10mg Tirz weekly I don’t yet have appetite suppression equalling 2.5mg of Sema. I am too likely to eat the wrong things, and my weight loss is erratic as a result.
Twelve mg doses of Tirz appear to be inevitable and necessary soon for continued success. Stacking Reta on Tirz would not seem to be a solution as I originally thought. The self-reporting I’ve seen suggests that Reta is no better than Tirz in re appetite suppression, and neither is as strong as Sema in that regard.
So my current thinking is Tirz OR Reta NO stacking as they have the same ‘weakness’.
Alternatively, stack a low dosage of Sema with Tirz. This could bolster its suppression and better support my slow but RELIABLE weight loss now that my Research Alligator 🐊 has had a two-month break from Sema 🤷🏻♂️
The results you achieve, whatever they may be, are interesting and highly relevant. Please continue to include me in your updates.
Dennis dionysos
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MrsRoper_1977
GLP-1 Specialist
Good morning,
I understand the frustration of not having appetite suppression. I think you are right on the inevitable of increasing the Tirz for your research. You’ve still got 5mg of room from the current dose of 10mg. Perhaps titrate more before considering the Sema stack?? This will give you some more time before resuming the Sema (perhaps another month or so).
Sounds like you are definitely looking at it from all angles. Just my thoughts. 😃
dionysos
GLP-1 Specialist
Thanks MrsRoper for putting a second set of eyes on my research challenges.
I and my Alligator very much appreciate your comments 🐊
I and my Alligator very much appreciate your comments 🐊
lagomorph
New Member
Thank you so much. I'm think I'm going to try it. If you don't mind possibly messaging me as to where you ordered it for your research study?
lagomorph
New Member
Thank you. I've noticed less fatigue recently with my research study and it's only for the first day afterwards that the fatigue is noted. So one day is not bad at all.
lagomorph
New Member
I've been taking it every day now and I really like it too. Helps with energy so it balances out the tiredness from reta nicely. It was always a problem I was frustrated with and even though reta was a lot better than the complete and total narcolepsy I had on tirz I still had issues with feeling tired. Especially the day after the Reta shot.
CiciZig69
GLP-1 Enthusiast
I am losing weight on Reta too. My issue is locating my dosage cheat sheet for next week!!!! Blimey!
CiciZig69
GLP-1 Enthusiast
What is the next dosage on Reta? I can’t find dosage calendar anywhere. Yikes.
MrsRoper_1977
GLP-1 Specialist
I’m not sure. I’m at 5 and the max is 12. I’ve decided to increase by 1-1.5 mg as I titrate up as needed.
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