Teso is awesome.

peptideusername said:
This is not medical advice:

If you have GLP1 fatigue and/or anhedonia, you should read up on tesofensine. It was originally aimed at neurodegenerarive disorders such as Alzheimer’s and Parkinson’s. Some benefits include:

— Mood enhancement/improvement
— Energy increase
— Appetite suppression

Warning: do not take while on SSRI medication. This can cause serotonin syndrome.

After 8 days of ~125mcg, my own personal research reflects those beneficial outcomes. It’s been a great week and I’m looking forward to the next one!

UPDATE

Day 9 (9/15):
At 1/4 tab (~125mcg) daily for the first 8 days, RS reports that the effects were stronger at first but have “leveled out”, which is a good thing.
Starting today, I’m going to research 1/2 tab, as 250mcg was the lowest amount used for clinical trials.

Day 13 (9/19):
As previously reported, on day 9 my RS was bumped up to 1/2 tab. It was too much for my RS. That dose only lasted one day, so back down to 1/4 tab on day 10, although the effects seemed to build over the next few days.
Day 12 was not great for my RS. With the extra bump in dose for that one day, the effects seem to have built to a point that was uncomfortable for my RS by day 12. Given its 9-day half life, I will be changing my RS’s protocol to 1/4 tab every other day. RS skipped day 13 and reported feeling more evened out.
I will say that looking back, I think it would’ve been wiser to wait that full 9 days, or maybe longer, before considering an increased protocol. RS also barely ate on day 12, likely due to those effects, which just compounded the yuck.
Click to expand...
Thanks so much for the update. These “ uncomfortable effects “ can you elaborate? B/P or heart palpitations? Insomnia? Headache? Thank you again🙂
 
SassyPants said:
Thanks so much for the update. These “ uncomfortable effects “ can you elaborate? B/P or heart palpitations? Insomnia? Headache? Thank you again🙂
Click to expand...
the discomfort was having “too much” energy. It was harder to focus because my mind was darting from thing to thing. It felt like being told to clean an hoarder’s house. Theres so much to do and you don’t know where to start. That feeling was the “peak” of the negative effects. I did notice a heart rate increase but that seemed to allay along with the previously explained “too much”. Insomnia, strangely, was not a factor. No headaches either, more of a mental exhaustion, and I’m sure that helped the sleep.
 
peptideusername said:
the discomfort was having “too much” energy. It was harder to focus because my mind was darting from thing to thing. It felt like being told to clean an hoarder’s house. Theres so much to do and you don’t know where to start. That feeling was the “peak” of the negative effects. I did notice a heart rate increase but that seemed to allay along with the previously explained “too much”. Insomnia, strangely, was not a factor. No headaches either, more of a mental exhaustion, and I’m sure that helped the sleep.
Click to expand...
Thanks for explaining this. Appreciate it!
 
peptideusername said:
the discomfort was having “too much” energy. It was harder to focus because my mind was darting from thing to thing. It felt like being told to clean an hoarder’s house.
Click to expand...
Just curious, do you have ADHD? This is what my brain feels like all the time, I simply lack the physical energy to get any of it done.
peptideusername said:
Theres so much to do and you don’t know where to start. That feeling was the “peak” of the negative effects.
Click to expand...
On the other hand, when I do have the physical energy, this is my biggest obstacle. This sounds like decision paralysis which I also struggle with constantly.

Now I'm wondering if teso might not be the right option for me. The reason I asked if you have ADHD is because I know medications like Adderall can make people without ADHD feel like this, and those with ADHD experience the opposite - so I wonder if the same may be true for teso.
 
moonpies4misfits said:
Just curious, do you have ADHD? This is what my brain feels like all the time, I simply lack the physical energy to get any of it done.

On the other hand, when I do have the physical energy, this is my biggest obstacle. This sounds like decision paralysis which I also struggle with constantly.

Now I'm wondering if teso might not be the right option for me. The reason I asked if you have ADHD is because I know medications like Adderall can make people without ADHD feel like this, and those with ADHD experience the opposite - so I wonder if the same may be true for teso.
Click to expand...
I do not have ADD or ADHD, but I understand exactly what you're saying because I have some experience with those types of ADD/ADHD drugs and there is definitely some overlap in terms of what those feelings felt like.

Now that I have lowered my teso dosage protocol, things are much better and I don't feel anything like I did that day. 1/4 tab every other day might be my sweet spot.
 
moonpies4misfits said:
Just curious, do you have ADHD? This is what my brain feels like all the time, I simply lack the physical energy to get any of it done.

On the other hand, when I do have the physical energy, this is my biggest obstacle. This sounds like decision paralysis which I also struggle with constantly.

Now I'm wondering if teso might not be the right option for me. The reason I asked if you have ADHD is because I know medications like Adderall can make people without ADHD feel like this, and those with ADHD experience the opposite - so I wonder if the same may be true for teso.
Click to expand...
I can speak towards it. I took a genetic test that tells me about my COMT genetic mutation. In my case, my dopamine and norepinephrine are elevated in my prefrontal cortex, which leads to the hyperfocus, lack of stress management, etc. The COMT gene in my case metabolizes acetylecholine very slowly. Side note, exercise and weightlifting help drain the acetylcholine for a little while. Adderall helps straighten out the dopamine signaling in the prefrontal cortex so a person feels those particular benefits. Adderall however is a weak modulator of norepinephrine.

Taking an SSRI for serotonin will also elevate your levels too much. A person might have taken Welbutrin and felt kinda off...

Taking an SNRI for norepinephrine like Strattera also again raises your/my already high norepinephrine. I came across this when I was prescribed Modafinil as an alternate ADHD treatment, and noticed my sleep was tootally jacked.

Anecdotally, I developed tinnitus when I took Welbutrin and blurry eyes when I took Modafinil. Low and behold there is some connection to both of those with norepinephrine!

I started digging down the rabbit whole into what will !reduce! norepinephrine, and it turns out another ADHD medication called Guanfacine will shuttle norepinephrine out of your prefrontal cortex and create a feedback loop to lower it. Lower norepinephrine helps you have normal conversations that are less stressful. Norepinephrine is also the main culprit in rejection sensitivity, and so on. I'm hoping at my next dr visit to ask for it..

I think I came across an abstract for a research article that made a connection where chronically elevated norepinephrine forces the alpha adrenergic receptors to tell your fat cells not to allow fat release. In normal people, norepinephrine goes up and down and normally tells fat to destroy itself.

So, while I loved the idea of Tesofensine raising Seretonin, Dopamine, and Norepinephrine; it became a hard no for me.

Instead of using Tesofensine, any other nootropics, or "head" medicines, take a look into Mirabegron (as a way to burn some extra calories while you sit). I've also found benefits in using oral testosterone (to maintain muscle mass), ezetimibe (clean the liver), cardarine (also liver), and some key supplements.
 
nask0 said:
I can speak towards it. I took a genetic test that tells me about my COMT genetic mutation. In my case, my dopamine and norepinephrine are elevated in my prefrontal cortex, which leads to the hyperfocus, lack of stress management, etc. The COMT gene in my case metabolizes acetylecholine very slowly. Side note, exercise and weightlifting help drain the acetylcholine for a little while. Adderall helps straighten out the dopamine signaling in the prefrontal cortex so a person feels those particular benefits. Adderall however is a weak modulator of norepinephrine.

Taking an SSRI for serotonin will also elevate your levels too much. A person might have taken Welbutrin and felt kinda off...

Taking an SNRI for norepinephrine like Strattera also again raises your/my already high norepinephrine. I came across this when I was prescribed Modafinil as an alternate ADHD treatment, and noticed my sleep was tootally jacked.

Anecdotally, I developed tinnitus when I took Welbutrin and blurry eyes when I took Modafinil. Low and behold there is some connection to both of those with norepinephrine!

I started digging down the rabbit whole into what will !reduce! norepinephrine, and it turns out another ADHD medication called Guanfacine will shuttle norepinephrine out of your prefrontal cortex and create a feedback loop to lower it. Lower norepinephrine helps you have normal conversations that are less stressful. Norepinephrine is also the main culprit in rejection sensitivity, and so on. I'm hoping at my next dr visit to ask for it..

I think I came across an abstract for a research article that made a connection where chronically elevated norepinephrine forces the alpha adrenergic receptors to tell your fat cells not to allow fat release. In normal people, norepinephrine goes up and down and normally tells fat to destroy itself.

So, while I loved the idea of Tesofensine raising Seretonin, Dopamine, and Norepinephrine; it became a hard no for me.

Instead of using Tesofensine, any other nootropics, or "head" medicines, take a look into Mirabegron (as a way to burn some extra calories while you sit). I've also found benefits in using oral testosterone (to maintain muscle mass), ezetimibe (clean the liver), cardarine (also liver), and some key supplements.
Click to expand...
I don't have COMT but I do have MTHFR and MTRR gene mutations. Wellbutrin didn't do a thing for me. Not a single side effect, nothing. Adderall used to kinda work for me before my ovaries were removed. Turns out if you have no estrogen Adderall doesn't work so well 😂 I was on HRT for a but not currently. I plan on seeing an endocrinologist soon because the GYN just randomly throws hormones at me without doing any tests. I should have much better luck with the Endocrinologist. I've also noticed MOTS-C has the opposite effect on me than most others, which seems to also be related. Every time I dig down this rabbit hole, I find more rabbit holes to explore.

The worst part of my ADHD is the inattentive aspect. That paired with fatigue makes it difficult for me to get *anything* done.
 
peptideusername said:
the discomfort was having “too much” energy. It was harder to focus because my mind was darting from thing to thing. It felt like being told to clean an hoarder’s house. Theres so much to do and you don’t know where to start. That feeling was the “peak” of the negative effects. I did notice a heart rate increase but that seemed to allay along with the previously explained “too much”. Insomnia, strangely, was not a factor. No headaches either, more of a mental exhaustion, and I’m sure that helped the sleep.
Click to expand...
Ok so i haven't read all these posts..so sorry if you have already covered this...the mind darting thing to thing..
Do you have adhd? I take adhd meds that another could take and feel like they were on speed lol. Always a lovely thing when you get diagnosed in your 40s and the doctor looks at you, to the test, to you, to the test, and says " I have no idea how you have made it this long..you have the worst case i have ever seen in 30 years" 😶
So with all that being said..lol..I wonder if this would actually work like my adhd meds.
 
Just ordered a bottle. Hopefully this gives me the boost I need🤞I have upped my Tirz and the fatigue has definitely hit me.
 
peptideusername said:
If you ordered from PGB, make sure you read their announcement about the teso/BPC snafu. You may end up with BPC tabs 😒
Click to expand...
I didn't order directly through a GB but I've confirmed it's a totally different vendor that color codes their tablets. Seems like this should be a common practice imho.
 
I've been lurking for quite a while but just wanted to chime in and give something back. I took my first dose of Teso 500mg today and I feel "normal." That's the best I can describe it.

I should note that I haven't felt "normal" in 25 years since I had to stop taking Ritalin. Diagnosed with ADD in college. Went cold turkey off Ritalin after getting my first job offer and being told I'd have to be off it to be hired. Over the years I've had to make do with lots of caffeine and coping mechanisms to get by. Doctors over the years have denied new scripts since I had been off them for years and doing "fine" so I obviously didn't need them.

Any way I started Tirz in late August. Currently doing 3mg Friday PM + 2mg Monday PM. I've been dealing with sluggishness since I started. I am down 20lbs from my highest recorded weight (288). I stumbled on this thread and it sounded like it might help with the fatigue and maybe help with the ADD as well. My plan is to add the 500mg to my Saturday AM and Tuesday AM as a pick me up for the Tirz fatigue. I will evaluate how it impacts the ADD and may adjust the dosing if needed to stay feeling normal.
 
Dee X said:
@peptideusername we demand an update on the original post, hasn't been updated since 9/19 😥
Click to expand...
Not a ton to update. Just been cruising along on 1/4 tab (125mcg) every other day for about a month now. Once I got through those few bumps in the road, things smoothed out and it’s going well.
I will reevaluate my protocol in a month or so because I am learning that my reduced body weight manifests itself in increased drug efficacy - much like my alcohol tolerance has lessened.
 
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I've been on a low dose for about a month. Don't feel any energy boost now. I'm not taking for appetite suppression more for mental clarity and focus. I think it does ok for that. When I say low dose I take about 250mcg every 2 to 3 days. If I take more than that it is hard for me to sleep. I don't plan on being on it forever and hope to taper down even more and see how I feel.
 
peptideusername said:
Not a ton to update. Just been cruising along on 1/4 tab (125mcg) every other day for about a month now. Once I got through those few bumps in the road, things smoothed out and it’s going well.
I will reevaluate my protocol in a month or so because I am learning that my reduced body weight manifests itself in increased drug efficacy - much like my alcohol tolerance.
Click to expand...
How’s your heart rate been? That’s my biggest concern in starting.
 
2nd 500mg dose for me wasn't nearly as beneficial. Had only 4hrs sleep the night before so was dead tired all day. ADD was uncontrolled. No focus no energy. Today mostly the same. Resting heart rate still sub 60bpm.
 
I was able to get about 7 hours of sleep last night. Today I felt a lot more energetic and clear headed again. So I think the lack of sleep was too much for it to overcome.
 
AndyPanda said:
Ava at +852 5134 9859 (Watsapp) has it. I don't remember what company she is with but I got the info on here. Last week she sent me a price list that had it on there. It was $60 for a 100 pill count bottle of 500mcg tablets. I am too worried about sleep interruptions to take it. I have a hard enough time as it is.

*** I just searched it, the company is Lianshui Peilun Daily Necessities
Click to expand...
I apologize for telling people about this company. I placed an order with Ava that included DSIP, 5 Amino 1mq, Oxytocin, NAD+ and LIPO-C w/B12. I received the package after waiting several weeks, and they didn’t send the LIPO-C, which was $130 alone and the most expensive item I ordered. I contacted her and at first she said they would send the missed item. Then, they tried to force me into buying something else and paying shipping again to get what I already purchased. Looks like I was taken for $130.

UPDATE* They corrected this and sent the kit. I stand corrected.
 
Last edited:
AndyPanda said:
I apologize for telling people about this company. I placed an order with Ava that included DSIP, 5 Amino 1mq, Oxytocin, NAD+ and LIPO-C w/B12. I received the package after waiting several weeks, and they didn’t send the LIPO-C, which was $130 alone and the most expensive item I ordered. I contacted her and at first she said they would send the missed item. Then, they tried to force me into buying something else and paying shipping again to get what I already purchased. Looks like I was taken for $130.
Click to expand...
You should ask Zipp to see if you can have this posted in the vendor review area.
 
IGezs said:
I've been lurking for quite a while but just wanted to chime in and give something back. I took my first dose of Teso 500mg today and I feel "normal." That's the best I can describe it.

I should note that I haven't felt "normal" in 25 years since I had to stop taking Ritalin. Diagnosed with ADD in college. Went cold turkey off Ritalin after getting my first job offer and being told I'd have to be off it to be hired. Over the years I've had to make do with lots of caffeine and coping mechanisms to get by. Doctors over the years have denied new scripts since I had been off them for years and doing "fine" so I obviously didn't need them.

Any way I started Tirz in late August. Currently doing 3mg Friday PM + 2mg Monday PM. I've been dealing with sluggishness since I started. I am down 20lbs from my highest recorded weight (288). I stumbled on this thread and it sounded like it might help with the fatigue and maybe help with the ADD as well. My plan is to add the 500mg to my Saturday AM and Tuesday AM as a pick me up for the Tirz fatigue. I will evaluate how it impacts the ADD and may adjust the dosing if needed to stay feeling normal.
Click to expand...
The ADD part is interesting. I notice my son has energy issues even on days he isn't working his blue collar job. Energy drinks when he is awake and sleeps a lot on weekends. Some of it might be depression, but I know he still has issues since he stopped taking Ritalin in college.
 
brittmiche said:
Wondering if teso helped with stressors of everyday adhd symptoms?
Click to expand...
Be careful. Do not take tesofensine if you are on adhd meds. It can kill you. Tesofensine is an MOAI and those react with many adhd meds. It increases your BP and can give you heart palpitations. Last Friday I tried tesofensine for the first time and I am on adderall. My BP was 153/103 and my heart was skipping a beat every 8 beats. It all subsided after 2 days and I am lucky to be alive. Tesofensine also has a half life of 220 hours. Adderall is 11-13 hours. I can't take aderall of another 2 days.
 
jwillhite6 said:
Be careful. Do not take tesofensine if you are on adhd meds. It can kill you. Tesofensine is an MOAI and those react with many adhd meds. It increases your BP and can give you heart palpitations. Last Friday I tried tesofensine for the first time and I am on adderall. My BP was 153/103 and my heart was skipping a beat every 8 beats. It all subsided after 2 days and I am lucky to be alive. Tesofensine also has a half life of 220 hours. Adderall is 11-13 hours. I can't take aderall of another 2 days.
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Damn thanks for the info. I'm sorry that happened to you. That's the thing with this route, self research. I feel that this info should be posted honestly, as a heavy portion of the earth's population is on adderall.
 
brittmiche said:
Damn thanks for the info. I'm sorry that happened to you. That's the thing with this route, self research. I feel that this info should be posted honestly, as a heavy portion of the earth's population is on adderall.
Click to expand...
It's made me alot more careful in the last week! I now research 3 times more than I did before and I was already doing alot
 
brittmiche said:
Wondering if teso helped with stressors of everyday adhd symptoms?
Click to expand...
I actually stopped taking it after a short period because I was prescribed an SARI to help with my sleep and didn't want to risk serotonin syndrome. My ADHD is still currently unmanaged but I feel some improvements with a combo of the SARI, Lipo-C (containing methylcobalamin), and starting HRT again.

My worst ADHD symptoms are of the inattentive variety and not being on HRT for a few years (I had my ovaries removed a while back) and struggling with B12 deficiency definitely exacerbated it and contributed to some cognitive decline. I'm finally starting to feel like that fog is lifting though.
 
Chizikitide-1977 said:
Haven't ordered this myself, but it looks like ASC has tablets.

Tuk Angel

Post in thread 'Price list --ASC'

Tesofensine----------$26 One tablet 0.5mg Bottle of 100 tablets
Ghk------------------$8/g
Primo-100 mg-------$33
Deca--200 mg-------$20
TestE--250 mg-------$19
  • Like
Click to expand...
I messaged Tuk about this. She says they’re reevaluating offering Teso as prices have gone up.
 
jwillhite6 said:
Still running strong! Haven't touched tesofensine since December.
Click to expand...
With the long half-life (like 9 days) you still have Teso in your system.

If you took 500mcg for >10 days it will not completely clear your system for over 80 days. This kind of shocked me when I put it into my half-life spreadsheet.

On the dosing side the amount of Teso in your body keeps increasing for like 5 weeks dosing every day. So taking a 500mcg daily dose after 5 weeks you have over 6mg in your body and then it starts to level off.
 
GimmeABreak said:
With the long half-life (like 9 days) you still have Teso in your system.

If you took 500mcg for >10 days it will not completely clear your system for over 80 days. This kind of shocked me when I put it into my half-life spreadsheet.

On the dosing side the amount of Teso in your body keeps increasing for like 5 weeks dosing every day. So taking a 500mcg daily dose after 5 weeks you have over 6mg in your body and then it starts to level off.
Click to expand...
Crikey .. this is invaluable info
 
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