Sunrise208
New Member
I am currently on Tirz but question myself if would it be better to make a move to Retatrutide or one of the others. I have lost about 20 + and have anoth 30 to go so just asking for your experience.
What's the Best GLP-1 to purchase that has the least Side effects
- Thread starter Sunrise208
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raw_oyster_eater
Senior Member
stay on triz. reta made my heart rate go to 130 at rest. semi makes me nausieous.
cagri has the brain clogging question.
cagri has the brain clogging question.
Lullabytreehugger
Registered
Try a dose of sema and see how you go. 0.5mgs should be ok if you already have experience with tirz. Most ppl get sides with sema after 1mg doses.
DwightTheDelight
Registered
Why are you wanting to switch? Are you losing super slowly, having sides, FOMO?
I've had a lot of success with tirz that I've worked up to 15mg/week over the past year, but have dabbled with Reta and Cagri just to see if it could speed things up. So far, I've been unimpressed, but it seems to be highly variable from person to person.
Recently, I've decreased the amount of days between tirz shots, and I'm satisfied again. I'm coming off of my best month in like half a year, so I may just keep doing tirz solo for the time being.
I recommend considering the same tactic as long as tirz is working.
I was having good success on tirz, but swapped to reta because of the higher reduction in fatty liver deposits (My ALT is the only "bad" item on my bloodwork) and less muscle loss.
It has increased my resting heart rate by about 12, so that's fairly significant. tirz did increase my resting heart rate as well, but only by about 5.
If you don't have specific reasons to swap, and one is working for you, I wouldn't swap.
It has increased my resting heart rate by about 12, so that's fairly significant. tirz did increase my resting heart rate as well, but only by about 5.
If you don't have specific reasons to swap, and one is working for you, I wouldn't swap.
I think Reta is a little overblown, saw some people saying it cured their adhd which seems not likely. If you’re trying to lose a decent chunk of weight with tirz expect plateaus from time to time, can go from loss everyday to stalling for 2 weeks. I would try the approach Dewayne suggested before considering Reta
I've seen a decent amount of people talking about GLP1s and ADHD in general, and on the surface, the science does seem to make sense.
Can GLP-1 Be a Target for Reward System Related Disorders? A Qualitative Synthesis and Systematic Review Analysis of Studies on Palatable Food, Drugs of Abuse, and Alcohol - PMC
The role of glucagon-like peptide 1 (GLP-1) in insulin-dependent signaling is well-known; GLP-1 enhances glucose-dependent insulin secretion and lowers blood glucose in diabetes. GLP-1 receptors (GLP-1R) are also widely expressed in the brain, and ...
pmc.ncbi.nlm.nih.gov
We know they have impact on the dopamine reward system. We also know that the dopamine reward system is considered dysfunctional in ADHD.
Evaluating Dopamine Reward Pathway in ADHD: Clinical Implications - PMC
Attention-deficit/hyperactivity disorder (ADHD)—characterized by symptoms of inattention and hyperactivity-impulsivity—is the most prevalent childhood psychiatric disorder that frequently persists into adulthood, and there is increasing evidence of ...
pmc.ncbi.nlm.nih.gov
I'm no expert here, and my understanding is that there is more to ADHD than just the dopamine stuff, but it seems feasible to my layperson understanding that GLP1s could help treat at least a portion of ADHD. If that portion is the thing that is most negatively impacting someone, it could possibly seem like a an ADHD "cure"
what's your current split for the 15mg?
I'm at 15mg every 6 days which is pretty much equal to 17.5mg every 7 days. im pushing tirz to the higher trial doses before stacking or switching anything else up first. already down 77lbs with tirz only so pushing a bit for science (lol) for these last 25ish pounds
DwightTheDelight
Registered
I'm on the exact same split. 15 every 6 days and it's crazy how much that has helped.
Congrats on your 77lbs btw!
Thank you!! How long have you been on the 15/6 split? Any plans to push it further to 15/5 or just go straight 20mg/25mg every 7?
Lullabytreehugger
Registered
How did tirz increase your heart rate when tirz has no effect on glucagon? Glucagon yes can increase your heart rate (so reta).
DwightTheDelight
Registered
I've been doing it for a month now. I'll be open to increasing the dose further if it's needed, hopefully I can hang out at 15/6 days for a while though
DwightTheDelight
Registered
This is a known effect of tirz as well. My increase was fairly substantial for the first month, but it's been back to normal for a while now.
Lullabytreehugger
Registered
It would be interesting to find out later down the track if they will trial the same thing with reta or not? Currently max weekly accepted dose is 12mg a week. I wonder if they may bum it up to like 16mg a week? In terms of strength and this is my personal opinion, reta is stronger than tirz. Sema is stronger than them both. I was not able to tolerate 1.5mgs of sema without severe sides. My max dose is 1mg even that I dont prefer. I can have 0.8 comfortably. With tirz I pushed 5 then 7.5 then 10 then even 12.5 but with no sides other than a bit of fatigue the day after injection. Reta I had racy thoughts as my main sides but pushed 2mgs then 4 then 6 then 8mgs. Still does not compare with Sema max dose my body likes of 0.8-1mg max before I start violently throwing up and non stop diarrhoea. Sema is one powerful drug man …
The Cardiovascular Effect of Tirzepatide: A Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Polypeptide Dual Agonist - PMC
Glucagon-like peptide-1 (GLP-1) receptor agonists have been used extensively in the clinic and have an established safety profile in cardiovascular disease settings. For the treatment of peptide-secreting enteroendocrine cells, most research has ...
pmc.ncbi.nlm.nih.gov
It is consistently reported in studies that tirzepatide can increase RHR.
My research on reta confirms elevated average and RHR as well.
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I’ve had really good results with Reta. I had Gastro issues with both Sema and Tirz, as well as some low energy days. Worst still I had persistent Gout outbreaks which went from 1-2 times per year to every 2 weeks.
I took a chance on Reta having read that it helped with fatty liver which I suspected was the root cause for some of my issues. 10 weeks in I am down 27 lbs, no gout, no gastrointestinal issues and good energy levels. The skin tags i had (fatty liver symptom) were gone a month in.
I took a chance on Reta having read that it helped with fatty liver which I suspected was the root cause for some of my issues. 10 weeks in I am down 27 lbs, no gout, no gastrointestinal issues and good energy levels. The skin tags i had (fatty liver symptom) were gone a month in.
DwightTheDelight
Registered
Now that you mention it, I'm just realizing all of my skin tags have vanished too.
Was all of that weight loss from Reta or did you have some initial loss from the sema and tirz?
Congrats on your progress btw!
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