Will anything ever bring the early magic back?

[mlke6]

I'm at a good weight to be goal weight now. I have noticed the same for the past maybe two months. I am starting to crave sugar like before. I get hungry and start thinking about food out of nowhere. I am eating more, more often but it seems like I still get full where before I never did.

I weigh myself every morning and there have been a few mornings where I just knew I blew it. I am maintaining my weight within 5 pounds. small fluctuations. I suppose if it continues like this and the hunger never comes like before the medicine this is actually ideal and a good place for me to learn and eat slower, with purpose, not skip meals so it comes on full force.

just my current experience

First pin April 2, 2024
sw:220
cw:157-161

 

[pepaccount]

i already take adderall so adding ephedrine isn't in the cards for me. i have taken it once or twice when i couldn't get the addys though. didn't help much for focus.

eh, sad to hear the magic is probably gone forever. hopefully it remains effective anyway even if i get hungry more often. as i type this i just finished off a small bowl of sloppy joe meat leftovers that would have filled me for hours previously and i don't even feel satisfied this time.

definitely going to 15mg tirz and upping the cag asap

You take Adderall and you're still hungry? Crazy.

 

[clayd]

You take Adderall and you're still hungry? Crazy.

Always been that way. I don't take a huge dose

 

[Laxfinity]

Also, if you don’t care about your wellness and really just don’t want to feel hungry for 12 hours at a time, you can always take a couple of bronkaid (ephedrine) tablets. Combined with tirz you definitely won’t want to eat.

Thanks for the reminder. I think I still have some of them stashed. I remember having to show my license for that purchase as they keep those behind the counter now.

 

[Laxfinity]

I don't normally post source questions but is Naltrexone available from the CN vendors or India pharma or do you need a telehealth script?

ADC.. India pharma

 

[Windingroads06]

My NP said I was in a tough spot when I complained that on the 5th-ish day I wanted to eat everything. She said it was just in my head.

Then I read the entire study on tirz and sema.
The half life is 5 days.

 

[WinterFarce]

My NP said I was in a tough spot when I complained that on the 5th-ish day I wanted to eat everything. She said it was just in my head.

Then I read the entire study on tirz and sema.
The half life is 5 days.

I pin every 5 days and I am golden the whole time. Nice smooth ride.

 

[PeptideJedi]

I read that if you did a 6week wash out you would be able to re-start at lower doses. I was at 10mg. I washed out for 6 weeks and re started at 5mg.
When I did that, I gained 8# and it took me a month to regain forward progress. 🤷‍♀️. I'm still loosing, just not as rapidly as before I think its not just the drug metabolism, but my whole metabolism had changed. Up to a point t I didn't put any effort into exercise. Ut maybe with this last 15#I might

I got to 15mg tirz still had alot to loose ..stopped everything for 6 weeks ..started back at 2.5 then 5 etc... now at 15 again
The way I see it stopping made it go alot longer then if I would had stayed at 15 .. it was a year ago I stopped..
Now at lowest weight ever

 

[clayd]

My NP said I was in a tough spot when I complained that on the 5th-ish day I wanted to eat everything. She said it was just in my head.

Then I read the entire study on tirz and sema.
The half life is 5 days.

yep, you'll find lots and lots of folks around these parts that add something else like sema or cag on day 4-5 to get them over the tirz hump, or adjust their tirz dosing to every 5 days.

 

[Sunflower]

There are at least 5400 women on Reddit who say you take 2.5mg for over a year, and it continues to work perfectly, and it is dangerous if you titrate up. I think you asked this question in a safe space lol

But yes, I started in Feb 2024 and Tirz does absolutely nothing for me besides give me some hard do doos for three days.

That is so funny how wildly different our bodies are, bc Tirz, and even moreso Reta now make me poop all day long 🫣 Before Tirz, I could go days without pooping. And I’m only on 2-4mg per week combined.

 

[Sunflower]

50mg. We'll see. The Wellbutrin was supposed to be for nicotine which didn't work but it turned out it did wonders for my mood when used with buspirone. The sema helped with the nicotine, I'm using almost none now it's mostly habit. I only just started it so I have no opinion on the nal yet, so far sema worked for alcohol by like 90%.

I honestly don't know, my pharmacy just kept not filling it for like five months then when my psych sent in a 90 day script instead now that she considers me Stable and Trustworthy (tm) all of a sudden they had it. I probably should have asked why, I would have happily just paid for it cash, I had to do that last year when my insurance wouldn't cover lamotrigine in anything less than 90 day supply.

WTF, like what do they think someone’s gonna do that’s dangerous/ shady with Naltrexone 😭 But yeah, I can empathize with the challenge of having to build “trust” with your psych. I’ve met all kinds of ignorant ones, but my current one is a psychedelic ketamine psychiatrist in Vermont (teleheath) so he’s surprisingly open minded!

Please keep us posted on your Nal experience—I am thankful Tirz fixed the food addiction, but struggling with residual mental “sticky/ disempowering thought” addictions and…Reddit. It seems like you’ve overcome 90+% of the physical dependencies, which is incredible.

 

[chmuse]

WTF, like what do they think someone’s gonna do that’s dangerous/ shady with Naltrexone 😭 But yeah, I can empathize with the challenge of having to build “trust” with your psych. I’ve met all kinds of ignorant ones, but my current one is a psychedelic ketamine psychiatrist in Vermont (teleheath) so he’s surprisingly open minded!

Please keep us posted on your Nal experience—I am thankful Tirz fixed the food addiction, but struggling with residual mental “sticky/ disempowering thought” addictions and…Reddit. It seems like you’ve overcome 90+% of the physical dependencies, which is incredible.

I'm bipolar and I started seeing them because I was unmedicated and having a hypomanic episode (looking back, I think I may have been actually manic and just not well enough to see it- just poorly enough to know I wasn't feeling RIGHT) so it makes sense they wanted me seeing them every month until I was stable. Then the first one stopped taking my insurance, and the second one sent me to another new psych when I asked for antabuse because she considered me a seizure risk (I wasn't, to be clear...) then another insurance issue.... 🙃 I've finally been with one long enough to go to every three months for appointments. I saw the same woman for seven years in my early twenties and I despised her, but that continuity of care was nice, looking back. 😅🥲

I'm now on nal, sema, AND cagri. I'm doing pretty damn great, but I can't tell you which of the three to attribute that to. Drinking also stops my weight loss progress, so having a concrete goal and consequences is helping. Drinking = sema no workie = no drinkie for ChMuse. From what I've seen sema seems best for those addictive behaviors (I've actually cut down on Reddit and TikTok by miles, I've read four books so far in January.)

 

[clayd]

I'm bipolar and I started seeing them because I was unmedicated and having a hypomanic episode (looking back, I think I may have been actually manic and just not well enough to see it- just poorly enough to know I wasn't feeling RIGHT) so it makes sense they wanted me seeing them every month until I was stable. Then the first one stopped taking my insurance, and the second one sent me to another new psych when I asked for antabuse because she considered me a seizure risk (I wasn't, to be clear...) then another insurance issue.... 🙃 I've finally been with one long enough to go to every three months for appointments. I saw the same woman for seven years in my early twenties and I despised her, but that continuity of care was nice, looking back. 😅🥲

I'm now on nal, sema, AND cagri. I'm doing pretty damn great, but I can't tell you which of the three to attribute that to. Drinking also stops my weight loss progress, so having a concrete goal and consequences is helping. Drinking = sema no workie = no drinkie for ChMuse. From what I've seen sema seems best for those addictive behaviors (I've actually cut down on Reddit and TikTok by miles, I've read four books so far in January.)

Very interesting story thanks for sharing.

Everyone said tirz curbed their drinking and it didn't change mine at all, but since I started in on the cagrisema, I have cut back, now that I think about it. Maybe sema is helping some there. It would be welcome assistance.

Naltrexone never seemed to really help me much but it did make me throw up all the time. Doc said that should subside but it never seemed to.

Glad you are in a better place @chmuse

 

[chmuse]

Very interesting story thanks for sharing.

Everyone said tirz curbed their drinking and it didn't change mine at all, but since I started in on the cagrisema, I have cut back, now that I think about it. Maybe sema is helping some there. It would be welcome assistance.

Naltrexone never seemed to really help me much but it did make me throw up all the time. Doc said that should subside but it never seemed to.

Glad you are in a better place @chmuse

Sorry for derailing 😅 Don't tell Yoyo.

Everything I've seen is that sema hits that receptor hardest and it seems to be the one that's helping with addictive behaviors. I think someone posted a chart saying survo and maz also work similarly? Sema is the one in active research for addiction medication, anyway. There's entire subreddits for it.

A lot of people seem to react to nal that way, which I think is part of why the Sinclair Method works.

 

[Umm.okay]

I started Tirz in July 2024 and it's been a successful ride so far. I am still losing, or not gaining, albeit slowly. Lost 45 pounds and about 15 or 20 to go.

I've stayed at 12.5mg till now, and I'm ready to go to 15mg on my next dose. But i've also been stacking cagri or cagrisema on day 5 of the tirz cycle to mitigate hunger.

The issue is that I just don't get the feels like I used to. I don't get the feeling that I'm full after a small portion, I don't get the food aversions or just absolute disinterest in snacking, and I don't get the ability to chug a protein shake for breakfast and forget about food until dinner.

I know there's a lot I could do. I can increase my dose a little, or take it more frequently. I can stack more cagri or sema or survo, I can transition to or stack reta...lots of options.

But what I really wonder is, is there any way to bring back the magic of those first couple months. I loved those days where I could just not think about food for 12 hours straight. Even when I increase my dose or stack, it doesn't seem to be the same.

Honestly it's not surprising to me that people start getting caught up in the suspicion they got a bad batch or a bad vial, or it's degraded or whatever. I don't think those things have happened to my products most likely, but I see why people think it. After some time, it just doesn't feel the same.

Is there any way to bring the magic back?

Hi there! I’m fairly new to all of this but just read a very interesting article that explains the plateaus in out weight loss journey and thought maybe it could help you.

Good luck in your journey!

file:///var/mobile/Library/SMS/Attachments/fd/13/2275B90E-AF75-4E8B-AF57-8CBE6187E294/Tirzapatide_The_Missing_Manual_v_0_95_20230901_Compressed_1.pdf

 

[Sunflower]

I'm bipolar and I started seeing them because I was unmedicated and having a hypomanic episode (looking back, I think I may have been actually manic and just not well enough to see it- just poorly enough to know I wasn't feeling RIGHT) so it makes sense they wanted me seeing them every month until I was stable. Then the first one stopped taking my insurance, and the second one sent me to another new psych when I asked for antabuse because she considered me a seizure risk (I wasn't, to be clear...) then another insurance issue.... 🙃 I've finally been with one long enough to go to every three months for appointments. I saw the same woman for seven years in my early twenties and I despised her, but that continuity of care was nice, looking back. 😅🥲

I'm now on nal, sema, AND cagri. I'm doing pretty damn great, but I can't tell you which of the three to attribute that to. Drinking also stops my weight loss progress, so having a concrete goal and consequences is helping. Drinking = sema no workie = no drinkie for ChMuse. From what I've seen sema seems best for those addictive behaviors (I've actually cut down on Reddit and TikTok by miles, I've read four books so far in January.)

Isn’t it exciting the possibilities we are seeing with the GLP1s and mental health?! Do you feel Sema has a stronger impulse control effect than Tirz?

Oh yeah, the challenges with bipolar are compounded when we are on an SSRI/ SNRI/ NDRI and then get mood shifts in mania/ hypo/ depression. It’s can be hard to distinguish what’s an actual bipolar symptom vs. medication exacerbating the mental state. And then there’s digging through (possible) childhood trauma trying to unravel how strongly that’s linked to bipolar. I wish we could all get regular brain scans while we are undergoing treatments 😆

 

[chmuse]

Isn’t it exciting the possibilities we are seeing with the GLP1s and mental health?! Do you feel Sema has a stronger impulse control effect than Tirz?

Oh yeah, the challenges with bipolar are compounded when we are on an SSRI/ SNRI/ NDRI and then get mood shifts in mania/ hypo/ depression. It’s can be hard to distinguish what’s an actual bipolar symptom vs. medication exacerbating the mental state. And then there’s digging through (possible) childhood trauma trying to unravel how strongly that’s linked to bipolar. I wish we could all get regular brain scans while we are undergoing treatments 😆

Bipolar has been linked to blood glucose! Increased risk of type 1 and 2 diabetes, and iirc a link was found with 1.5 recently too. 😬 So a glp-1 helping makes a ton of sense to me- especially as keto had mine so well controlled until I couldn't maintain such a strict diet. No opinion on tirz, I haven't tried it yet. Sema had an immediate effect for me- within hours of the first dose, it was like a button in my brain had been pressed. Magic. I've only done sema and one dose of cagri so far (second dose tonight.) And parsing through everything is so incredibly difficult, sooooo many possible and common comorbidities, and environmental factors, etc etc.

 

[brittmiche]

I started Tirz in July 2024 and it's been a successful ride so far. I am still losing, or not gaining, albeit slowly. Lost 45 pounds and about 15 or 20 to go.

I've stayed at 12.5mg till now, and I'm ready to go to 15mg on my next dose. But i've also been stacking cagri or cagrisema on day 5 of the tirz cycle to mitigate hunger.

The issue is that I just don't get the feels like I used to. I don't get the feeling that I'm full after a small portion, I don't get the food aversions or just absolute disinterest in snacking, and I don't get the ability to chug a protein shake for breakfast and forget about food until dinner.

I know there's a lot I could do. I can increase my dose a little, or take it more frequently. I can stack more cagri or sema or survo, I can transition to or stack reta...lots of options.

But what I really wonder is, is there any way to bring back the magic of those first couple months. I loved those days where I could just not think about food for 12 hours straight. Even when I increase my dose or stack, it doesn't seem to be the same.

Honestly it's not surprising to me that people start getting caught up in the suspicion they got a bad batch or a bad vial, or it's degraded or whatever. I don't think those things have happened to my products most likely, but I see why people think it. After some time, it just doesn't feel the same.

Is there any way to bring the magic back?

This just isn't healthy. And you will thoroughly regret it by the time you reach your goal weight.

 

[sepehr]

Similar experience:

Post in thread 'Eating a lot while on 7.5mg/w tirzepatide'

Feb 1, 2025

Sprinkle in a little cheap semaglutide on it...

Or increase the Tirz dose...

I think also you'll have some days where the Tirz is effective and some days where you feel like raiding the cookie jar. Is it real hunger or is your brain telling you if you have a snack you'll feel better?

Mostly for me I'm not hungry but I eat anyway.

Couple thoughts.... For your RS. I'd probably stack a little Semaglutide on the regimen. If you do this... don't get fancy with a shot of it every other day.... follow the recommended weekly titration schedule.

Thanks for the advice.

It's not physical...

• sepehr

 

[hotdog!]

This just isn't healthy. And you will thoroughly regret it by the time you reach your goal weight.

This seems like a big assumption without giving any good reasons.

 

[clayd]

This just isn't healthy. And you will thoroughly regret it by the time you reach your goal weight.

Thanks I'm reconsidering everything now

 

[jas0441]

I have been on 15 mg. tirz since Christmas (literally) and down only 0.5# in that time. Not feeling the magic anymore BUT I am sticking with it because there are still some positive benefits I am getting like inflammation reduction and alcohol suppression.

Even though I am not getting good appetite suppression it is still helping me eat healthy and moderately, I don't crave sweets or eat fast food. I have double downed on calorie counting, reassessed my TDEE and just working harder to stay in a calorie deficit, which I am relatively successful at using tirz. So trying to appreciate some of the positive benefits I am still getting and staying the course. Its just going to take me a lot longer to lose the weight, but maybe that is a good thing?

 

[cldfront]

It seems like there is a vocal minority complaining that there's something wrong (or they got zero) with their grey peps because they're not getting the feels like they used to without any test data to back it up. I think a lot of folks want the early magic back and might have expected it to last forever... it is indeed a bummer!

 

[hotdog!]

I agree that the magic feels disappearing or being blunted is a big disappointment. I miss it myself.

 

[FrankTdog]

Bipolar has been linked to blood glucose!

That was a fun rabbit hole, thanks for the lead. As a one datum experience, my spouse is mildly bi-polar and has been much steadier since being started on sema. I never made the connection, but your comment def got me thinking.

 

[chmuse]

That was a fun rabbit hole, thanks for the lead. As a one datum experience, my spouse is mildly bi-polar and has been much steadier since being started on semi. I never made the connection, but your comment def got me thinking.

Very exciting stuff. Keto has also been linked to helping bipolar, which makes sense when you consider a lot of the first line bipolar treatments are actually epilepsy medications- and keto is a diet specifically prescribed to control epilepsy! Keto can also be used to help with diabetes and blood sugar control. It's so cool how all these weird things are linked!

 

[keangkong]

I started Tirz in July 2024 and it's been a successful ride so far. I am still losing, or not gaining, albeit slowly. Lost 45 pounds and about 15 or 20 to go.

I've stayed at 12.5mg till now, and I'm ready to go to 15mg on my next dose. But i've also been stacking cagri or cagrisema on day 5 of the tirz cycle to mitigate hunger.

The issue is that I just don't get the feels like I used to. I don't get the feeling that I'm full after a small portion, I don't get the food aversions or just absolute disinterest in snacking, and I don't get the ability to chug a protein shake for breakfast and forget about food until dinner.

I know there's a lot I could do. I can increase my dose a little, or take it more frequently. I can stack more cagri or sema or survo, I can transition to or stack reta...lots of options.

But what I really wonder is, is there any way to bring back the magic of those first couple months. I loved those days where I could just not think about food for 12 hours straight. Even when I increase my dose or stack, it doesn't seem to be the same.

Honestly it's not surprising to me that people start getting caught up in the suspicion they got a bad batch or a bad vial, or it's degraded or whatever. I don't think those things have happened to my products most likely, but I see why people think it. After some time, it just doesn't feel the same.

Is there any way to bring the magic back?

You've gotten closer to your goal weight. What happened is normal. I used to get taller. It doesn't happen anymore.

 

[brittmiche]

This seems like a big assumption without giving any good reasons.

Jesus fucking Christ. Yall act like it's not important to fucking eat good healthy foods while taking this shit. Cool, have a saggy ass, thighs, arms, etc. Especially if you were "obese" upon starting. Op literally said in a round about way, they do not want to be hungry or think about food for 12hrs plus other factors I will not list, bc quite frankly the attitude here is rediculous-you are more than welcome to go back and read. Thus should be a place where we can share experiences and earn/teach others about the possible/likely outcomes of certain routines and habits with their meds.

 

[hotdog!]

Jesus fucking Christ. Yall act like it's not important to fucking eat good healthy foods while taking this shit. Cool, have a saggy ass, thighs, arms, etc. Especially if you were "obese" upon starting. Op literally said in a round about way, they do not want to be hungry or think about food for 12hrs plus other factors I will not list, bc quite frankly the attitude here is rediculous-you are more than welcome to go back and read. Thus should be a place where we can share experiences and earn/teach others about the possible/likely outcomes of certain routines and habits with their meds.

Well telling someone they will "thoroughly regret it" is a really presumptuous thing to say. Especially given we're all taking "research" grey market drugs that come with a lot of risks. The attitude you're reading is calling out your judgmental comments masquerading as helpful advice. So Jesus Fucking Christ yourself.

 

[clayd]

Jesus fucking Christ. Yall act like it's not important to fucking eat good healthy foods while taking this shit. Cool, have a saggy ass, thighs, arms, etc. Especially if you were "obese" upon starting. Op literally said in a round about way, they do not want to be hungry or think about food for 12hrs plus other factors I will not list, bc quite frankly the attitude here is rediculous-you are more than welcome to go back and read. Thus should be a place where we can share experiences and earn/teach others about the possible/likely outcomes of certain routines and habits with their meds.

I think the issue is that you're making a lot of assumptions about what I'm doing without really knowing.

Humans probably did not eat 3 square meals a day for most of history. Hunter/gatherers probably had long fasts interrupted by the occasional feast. Not eating or needing to eat for 12 hours is perfectly fine, it's not like I do it every day. And I probably never really did it much. But what was nice in the beginning was not to be driven around hour by hour by the perceived need for food. Not necessarily fasting for 12 hours, but feeling like you can live the rest of your life without thinking about eating all day long.

Trust me I still get plenty of calories. But thanks for your concern