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I'd be curious to see body comp results before and after tho, because my bet is that IGF-1 agonism is in there to help reduce lean mass (inc muscle) loss.

This is talking about amyloid-beta protein, not amylin -- amylin's full government name is islet amyloid polypeptide or IAPP. Amyloid-β was the OG amyloid discovered, so it got the name before they realized there were many other kinds of amyloid as well. Re BBB, quoting from PNN over on RT:

You likely won't feel additional food noise suppression with Reta, at least not until you hit much higher doses, because it doesn't hit that receptor as hard. It seems to go Sema > Tirz > Reta for appetite suppression, tho it will still slow gastric emptying about the same as Tirz. I'm hungrier...

Not just you -- I thought it was due to having less insulation... but it's a really weird feeling and kinda doesn't feel like regular being cold. I started wearing slippers because my feet are always cold now. 100% in my Grandma Tirz era now.

It likely shipped domestic, they do have some stocked in the US.

Same -- my experience has been that China Post is not fast, but QSC's packing is slow as well. I've had multiple orders from different Chinese suppliers, also places like Temu, land in the time it takes QSC to even get it into China Post's hands with active tracking. But they also just moved...

Thanks for the rec!! I really enjoyed listening. And... I completely understand where they're coming from re: reconstitution, tho I disagree (I'm special so don't need gatekeepers! Sez everyone, probably, but definitely me ;) ) but... I get it. I hear it on two fronts from the medical...

It isn't just injection-site reactions either; peptides are generally acidic and are buffered during freeze-drying. (Fun fact, humans are a bit acidic too). Anything too alkaline may denature the proteins that peptides are made up of.

It was mentioned in your thread multiple times, starting from the first report months ago. But glad you finally replied here. Spoke with a medical clinic that offers it and no, they do not need to reconstitute it with anything but saline. Definitely room for improvement, as that's pretty poor...

Multiple users now are reporting that it has a super low pH -- around 2.5, which would be like injecting vinegar. One person could barely weight-bear on their leg for a week after injecting it. This is not how it should normally be, peptides should be buffered during manufacture. If you inject...

Welcome!

Random aside: highly recommend Zotero!! Used by academics mostly -- I was spreadsheeting it and it was struggle to stay organized... went on a hyperfocus binge of Tesamorelin research and started using the standalone (non-cloud) app + browser plugin and it's fantastic. It grabs a copy of the...

Oh that's awesome. One of the things might be figuring out what is worth a factory sized order. For the Canadians, AP has been amazing as our borders are a bit sticky sometimes. Skincare might be the way to go next after weight loss. A few local and reputable clinics offer NAD+ infusions, so...

What's the dosing you're using on that subQ per kg?

Oh nice, thank you, had no idea this existed, will check it out!

Which is that colloquially known as -- Melanotan? or Melanotan 2? Iirc M2 has some safety questions around heart arrythmias, so I'm a bit cautious on that one. But bumping up BMR is interesting -- I wonder if it stays up after. If so I wonder this could be cycled for a decent result without...

Thanks for that tip about methylated vs non, that was a fun rabbit hole of reading!! I grabbed some Methylated B12 from AOR* and it seems to have helped immensely with my day-after-shot exhaustion. * AOR (Advanced Orthomolecular Research) is a Canadian company I found that supplies universities...

What's the success rate for shipments making it to Canada these days? ETA: don't seem to have perms to ask in vendor thread, not sure if that's a user level thing or what, so asking here!

I recognize so many avis from so many places, we'll all end up here eventually... 😅 welcome!

Fantastic. Looking forwars to the Phase3 results and working the Tirz for now but it's awesome to know this option is here when I'll inevitably need it! Kudos to you interpid scientists trying it out now.

I saw someone somewhere else recommend Spermidine wheat germ supplements, and from my brief glance at the research, it looks compelling. Not a peptide, but something that would compliment for sure!

It's so strange, right? I have to force myself to eat, and honestly feel a bit relieved when the hunger comes back sometimes because I'm definitely struggling to get my basic fuel in each day. But it's so nice to finally control it, vs the other way around!

No fancy freezer here, but since I'm into home improvement and have a lot of offcut insulation lying around I foamed/taped together a breadbox-sized cube that's around R10 and put my Vial Vaults boxes inside that in the freezer. Behind the ice cream for thermal mass since I can barely eat it now...

This is the half-life plotter sheet that also has some tabs for tracking orders, prices, and info! Super helpful. https://docs.google.com/spreadsheets/d/1FwCFJ3UJgckGleRGj4znAo5CKdH69V3dgIPGTwY3BVc/edit?usp=drivesdk

Thank you!! That was a good read, but I worry that this might bring a lot of attention to the industry and not in a good way.

I believe it already does, according to the latest price list--express shipping is avail for Tirz/sema/reta.

Agree that they've got SOME good reasons for keeping their culture unwelcoming, but ...law enforcement is actually pretty well aware. Heck, I'd guess 1/4 of their users are LEO or military too... There are newsletter mentions, office bulletins, and even academic papers about the existence of...

Brilliant calculator here for those who are taking more than one thing and want to reduce the number of pokes: https://peptide-blend-calculator.glitch.me/

I have 17 10mg vials and I'm currently pondering picking up another 10... just in case... maybe make it 20

Discovered Tirz a few months ago and it changed everything. Walked the maze of forums big and small, escaped Reddit somehow unbanned, landed on the wonderful testing Discord... and then ended up up here! I really like the idea of a place to talk peptides and GLP1s specifically that has a bit...

A respected local PS here in Canada is offering NAD+ through his practice. He's def not a quack, so... they do 2-3 IV infusions but I have no idea the dosage. May pick some up if I spot it from one of my usual sources -- this dosage guide was super helpful, ty!