What Percentage of Body Weight Have You Lost?

[keangkong]

I was looking at the mouse study on Retatrutide and cancer. https://www.nature.com/articles/s44324-025-00054-5 The cancer implications are very interesting on its own, but that is not the purpose of this post. The other thing that caught my eye in the study is that the mice lost 40% to 41% of body weight and stabilized there. We have the Phase II data of 24.2%, but people were still losing weight after 48 weeks. There is no published data on when it plateaus. EL has extended the studies, so it looks like they are trying to find that out.

I have been stacking Tirz and Reta for 8 1/2 months. I have lost 35% of my body weight and I am still losing. I would like to get down to 40% to reach my ideal weight. My question is for people on maintenance or close to maintenance; what percentage of your body weight have you lost? Has anyone hit 40%, or more?

I lost 20 percent of my weight. However, I had to add a second weight loss drug to get there. I probably would have gotten to 20 percent on tirz alone if I could tolerated the maximum dose.

I believe the people who are posting are on the high side of what people typically lose.

 

[desinr-gal]

I feel like a little fish after reading all of your posts! I’m down 7% over 6 weeks. Trying to keep it about -1% per week or less. I don’t really know how it’s calculated though. Always from starting weight?

you'll get there!
Yes # of lbs lost divided by starting weight.

 

[Dos-Dox]

7% in 13 weeks, but I’ve only been able to run 2 weeks cycles (i.e. 1 dose per week for 2 weeks and then none for 2 weeks) at a time because of my job. I am completely fine with the slower progress as it’s still a heck of a lot faster than I was able to do it the previous 2 years. I’ll be retired soon and can research uninterrupted after that.