What Percentage of Body Weight Have You Lost?

[keangkong]

I was looking at the mouse study on Retatrutide and cancer. https://www.nature.com/articles/s44324-025-00054-5 The cancer implications are very interesting on its own, but that is not the purpose of this post. The other thing that caught my eye in the study is that the mice lost 40% to 41% of body weight and stabilized there. We have the Phase II data of 24.2%, but people were still losing weight after 48 weeks. There is no published data on when it plateaus. EL has extended the studies, so it looks like they are trying to find that out.

I have been stacking Tirz and Reta for 8 1/2 months. I have lost 35% of my body weight and I am still losing. I would like to get down to 40% to reach my ideal weight. My question is for people on maintenance or close to maintenance; what percentage of your body weight have you lost? Has anyone hit 40%, or more?

I lost 20 percent of my weight. However, I had to add a second weight loss drug to get there. I probably would have gotten to 20 percent on tirz alone if I could tolerated the maximum dose.

I believe the people who are posting are on the high side of what people typically lose.

 

[desinr-gal]

I feel like a little fish after reading all of your posts! I’m down 7% over 6 weeks. Trying to keep it about -1% per week or less. I don’t really know how it’s calculated though. Always from starting weight?

you'll get there!
Yes # of lbs lost divided by starting weight.

 

[Dos-Dox]

7% in 13 weeks, but I’ve only been able to run 2 weeks cycles (i.e. 1 dose per week for 2 weeks and then none for 2 weeks) at a time because of my job. I am completely fine with the slower progress as it’s still a heck of a lot faster than I was able to do it the previous 2 years. I’ll be retired soon and can research uninterrupted after that.

 

[jaypoll1977]

Since March i have dropped 33.8kgs and i am now 2.1kgs from my goal weight low dosing on reta, aod9604 and cjc1295/ipamorelin and weights 4 times a week.

 

[randompersonrandom]

18% so far. Tirz since July 29th, tiny stack of Survo since October.

 

[Mc_ppka_tp]

I started using Reta on October 15th. I am down 9.5% now. Not a huge % but I'm satisfied with it. Heck it is progress and I'm preparing for a marathon and not a sprint.

 

[GLP1Pharmacist]

My update 42.14% down!

 

[desinr-gal]

My update 42.14% down!

👏 👏 👏

 

[Not_Your_Dad]

I've been on Tirz for about 9 months -- down 54 lbs, which is bang-on 20% for me. Mrs. Not_Your_Dad has been on Tirz for about 18 months, and is down 110 lbs which is 43.3% for her.

 

[m100568]

I feel like a little fish after reading all of your posts! I’m down 7% over 6 weeks. Trying to keep it about -1% per week or less. I don’t really know how it’s calculated though. Always from starting weight?

7% in 6 weeks is amazing. Congratulations!

 

[desinr-gal]

18% 29 wks. 3mg tirz 3mg Retta; oddly close to 8mg reta trial results.

 

[Sasquatch]

15.5% in 10 months.
Titrated up to 12.5mg tirz. for 1 week so far.

 

[Rootus346]

Just a couple days past 14 months into the research, I am down 35.5%. Or put another way, 101 pounds. Six of those pounds came in the last week because I switched to reta from tirz. I'm titrating down the reta right now because the appetite suppression is too strong for me at the dose I have been taking and it's hard to get proper nutrition.

I'll most likely switch back to tirz for maintenance after another 10 pounds or so. I titrated it down a bit for a month leading up to my trip to Disneyland in October and it worked out wonderfully. Weight loss stopped, but did not reverse, and no side effects all, even minor ones. Could be happy on that dose forever.