Who is currently or was previously above a 15mg dose?

[GimmeABreak]

I read somewhere big flower is currently testing up to 20 or 25.

I think at some point it just stops helping you lose weight. She is at 28-30mg a week but in maintenance. She said it just takes the edge off appetite and helps with food noise.

If you look at the trial data most people, regardless of dosage, stopped losing weight after about 60 weeks. What the data doesn't tell you is if you can extend this period by titrating up over a long period of time. In other words, if the people on 5mg titrated to 10mg after the weightloss stopped, would they lose weight beyond the 60 weeks?

 

[Nikki nik]

There is a women on a couple of the major Discord servers taking 28-30mg of Tirz.

I guess if it works and frequent blood test. Sounds good to me. I think I would try it. 5mg every other day?

 

[Nikki nik]

I think at some point it just stops helping you lose weight. She is at 28-30mg a week but in maintenance. She said it just takes the edge off appetite and helps with food noise.

If you look at the trial data most people, regardless of dosage, stopped losing weight after about 60 weeks. What the data doesn't tell you is if you can extend this period by titrating up over a long period of time. In other words, if the people on 5mg titrated to 10mg after the weightloss stopped, would they lose weight beyond the 60 weeks?

Hmmm I wonder too.

 

[GimmeABreak]

I guess if it works and frequent blood test. Sounds good to me. I think I would try it. 5mg every other day?

Nope, 28-30mg every 7 days.

 

[normal]

Currently at 15, will be doing 5th dose tomorrow. I'm about 3lbs from my goal weight. Started Feb. 24.
6'2" big framed, goal weight is 245.

Damn hell yeah, congrats on the major loss

 

[chmuse]

I think at some point it just stops helping you lose weight. She is at 28-30mg a week but in maintenance. She said it just takes the edge off appetite and helps with food noise.

If you look at the trial data most people, regardless of dosage, stopped losing weight after about 60 weeks. What the data doesn't tell you is if you can extend this period by titrating up over a long period of time. In other words, if the people on 5mg titrated to 10mg after the weightloss stopped, would they lose weight beyond the 60 weeks?

That's why I'm sticking with sema as long as possible. When sema stops working, I've still got tirz and reta to try. Maybe survo or maz. The options will be numerous by then.

I'm also open to stacking if sema still helps with noise but not with weight. I never want noise again. 🥲

 

[Sunflower]

Which dose of mots c?

First dose I used 10mg (1whole vial). My understanding is 10mg may be the upper ceiling of dosing, ideally once or twice per week. It seems like those using 5mg or less per dose are using it every 2nd or 3rd day for the cycle duration.

 

[bacidolci00]

I went up to 25mg the past 2 months. I started tirz Aug 1st 2023 and lost my first 30lbs on just 2.5mg and then my weight loss slowed so I started titrating up and by a year in, I had hit 60lbs down and up to 15mg but I still wanted to lose another 60lbs. I was only dropping about 1lb a month since the summer so I decided to try going up. Did 20mg for a month in November/December and then went up to 25mg. I didn't find it helped lol. Actually the thing that has seemed to help the most is moving my injection back to my thigh! I went down about 3-4lbs since doing that at the beginning of the month lol.

I personally have had VERY few side effects from tirz the whole time I've been on it. It made me sleepy in the very beginning on shot days and I have had some constipation here and there, but it's mostly only helped with satiety and less so with appetite reduction and food noise. Honestly, if I hadn't lost weight, I would think I was taking a placebo or was just a non-responder.

I've gone back down to 15mg this last shot because I was trying to get my order in with QSC before CNY and seemed to have missed them, so now I need to stretch out the rest of my supply to last until next month. I'm also going to start stacking with sema to try and get some actual appetite reduction help and hopefully start things back up again.

 

[clevesand]

I'm currently on my last 15-20lbs to lose. For the life of me I'm chicken to go up. I'm only at 7.5 started in May. I love how you say FucK it SciencE! I'm there because this is not working for me. I'm thinking going up to 10mg because nothing is happening. I've been on 2.5 most of the way. I guess after 7 months my body is not accepting low doses. I'm ready to pull that trigger for the last few lbs.

For what it's worth, I noticed no differences between 5mg-15mg in terms of side effects that got any worse. I also started in May. I always broke my stalls by eating bad for a couple days. It definitely resets something in my body. 4th of July weekend was excellent for me lol

 

[Blitziod]

There is a women on a couple of the major Discord servers taking 28-30mg of Tirz.

My goal weight is 189 pounds. My start weight was 268. I’m down to 206. I can’t imagine a woman weighing 150 and I should have the same max dose.


I started on sema in sept of 23 . Maxed out at 5 mg after almost 12 months. Got down to about 216 and stalled a bit. Took a little time off as I had 2 minor surgeries( colonoscopy and nose surgery ). They wanted 2 weeks for each off meds. Plus a month in between. I switched to tirz on the month in between. 2.5 to start. Then went to 5 after. Didn’t really have much luck. Started to feel it at 7.5 and then started losing again at 10. Now I’m at 15 and still slowly losing. I’m going to keep on 15 for a few weeks. If I don’t lose any more I may make a change. Either up the dose , try Reta or add Cagri to the tirz.

Also considering Tesamorelin as I get closer to my goal to help with some still stubborn stomach fat. I’ve heard it’s good for the last few pounds.

 

[nonyabizznez]

My goal weight is 189 pounds. My start weight was 268. I’m down to 206. I can’t imagine a woman weighing 150 and I should have the same max dose.


I started on sema in sept of 23 . Maxed out at 5 mg after almost 12 months. Got down to about 216 and stalled a bit. Took a little time off as I had 2 minor surgeries( colonoscopy and nose surgery ). They wanted 2 weeks for each off meds. Plus a month in between. I switched to tirz on the month in between. 2.5 to start. Then went to 5 after. Didn’t really have much luck. Started to feel it at 7.5 and then started losing again at 10. Now I’m at 15 and still slowly losing. I’m going to keep on 15 for a few weeks. If I don’t lose any more I may make a change. Either up the dose , try Reta or add Cagri to the tirz.

Also considering Tesamorelin as I get closer to my goal to help with some still stubborn stomach fat. I’ve heard it’s good for the last few pounds.

If you're saying you maxed out at 5mg Sema that's 2.5x the max dose of Ozempic. Proportionally be 37.5mg Tirz! Is that what you meant to say?

I think a bit of Cagri while maybe lowering your Tirz dose might be worth trying... I'd say whataya got to lose but you know. 🙄

 

[Blitziod]

If you're saying you maxed out at 5mg Sema that's 2.5x the max dose of Ozempic. Proportionally be 37.5mg Tirz! Is that what you meant to say?

I think a bit of Cagri while maybe lowering your Tirz dose might be worth trying... I'd say whataya got to lose but you know. 🙄

My bad. I meant to say 2.5 mg of sema. It has been a few months

 

[brentm]

I'm dosing 20mg Tirz stacked with 1.5mg Sema.

Nice suppression.

 

[Yankeegurl_LQJ]

I'm taking 15mg every 5-6 days, but a couple of times I've done it with just a 4 day separation between shots and experienced no major side effects. At first, I felt the incredible appetite reduction that I did when I first began taking tirz in Jan of last year, but now it just feels like every other dose. I'm happy to have it still, don't get me wrong, but I do really miss those first few months on tirz. They were magical.

Sounds like it acts the same as most other meds/drugs. Good in the beginning and then you start to build a tolerance so you have to go up and up...

 

[Blitziod]

I'm dosing 20mg Tirz stacked with 1.5mg Sema.

Nice suppression.

Do you dose all the same day ? Or what’s your schedule?

 

[brentm]

Do you dose all the same day ? Or what’s your schedule?

No, every 3.5 days... 10mg tirz and .8mg sema every 3.5ish days.

EDIT: I also know someone who is on 30mg of Tirz weekly.

 

[SassyPants]

I read somewhere big flower is currently testing up to 20 or 25.

Yeah, me too.

Also there have been users of Sema reporting that trial doses of Sema have reached 7.2mg a week and considered safe.😬 To me that seems like way too much but others have had minimal issues and much success in the STEP UP trial. https://www.appliedclinicaltrialsonline.com/view/step-up-trial-semaglutide-superior-weight-loss

 

[scarywood75]

I think we are good, by the time our tolerance would be too high, they'll patent something new

What a time to be alive

 

[adria37]

I took 15 mg every 5 days for several months and now take 15 every 6 or 7 days. The biggest issue I have had is with headaches for 2 days post injection. It doesn't matter what dose I am on it started at 2.5 mg and continues. I try to dose on Friday AM so I am off during the worst of it.

 

[AndyPanda]

I think with overfill I have definitely been above 15mg. Not intentionally though. I’m waiting for a good deal on Cagri to add that.

 

[janedoe]

I moved up to 15mg Tz in late January. Current, slow loss, almost a stall, 10 lbs from goal. Last couple weeks, no scale movement. Oddly, Heart rate appears to have increased slitely during the 15. My game plan hasn't changed. I'll stay at 15 until goal, then transition to Reta w/ Cagri stack of .125 initially.

 

[raw_oyster_eater]

No, every 3.5 days... 10mg tirz and .8mg sema every 3.5ish days.

EDIT: I also know someone who is on 30mg of Tirz weekly.

can they poop at all?

 

[brentm]

can they poop at all?

heh. I didn't ask.

Been trying to come up with a protocol for myself as that is somewhat of a problem area. Right now I'm settling in on 3-4 ducolax (actually costco generic) a day. And it seems to be the ticket for smooth audits.

 

[Yankeegurl_LQJ]

can they poop

heh. I didn't ask.

Been trying to come up with a protocol for myself as that is somewhat of a problem area. Right now I'm settling in on 3-4 ducolax (actually costco generic) a day. And it seems to be the ticket for smooth audits.

For sure! I use cherry Dulcolax before bed every 2-3 nights and it usually works soon as i wake up or within the hr. It hasn't let me down yet. Everyone is saying Mag07 but it is basically the same thing only without the H2O. Besides, Dulcolax is cheaper ($5.00 walmart). Also, it's more gentle and non-cramping. To each their own. In the end it don't matter what you use to 💩 as long as you get to 💩 😁

 

[brentm]

For sure! I use cherry Dulcolax before bed every 2-3 nights and it usually works soon as i wake up or within the hr. It hasn't let me down yet. Everyone is saying Mag07 but it is basically the same thing only without the H2O. Besides, Dulcolax is cheaper ($5.00 walmart). Also, it's more gentle and non-cramping. To each their own. In the end it don't matter what you use to 💩 as long as you get to 💩 😁

Yeah, I think of it as a safety issue.

Without anything, it's a struggle. I tried magnesium and Miralax daily which seemed to work OK. But when I was at Coscto I couldn't find the mag at the doseage I wanted and I was just unsure if it was the right choice. So in haste I bought this Docusate Sodium bottle. I don't recall the price but there is 400 gel caps in there. Easy to take. Does the trick.

One case of a death related to GLP1s that I've read about was caused from complications of a perforated bowel. I assume due to constipation.

But now with this regimen I'm extruding fine. Before that I'd use the Fleet product which seems like it should be an emergency only situation. I don't want to describe it so you'll have to look up Fleet. But it was a real hassle and no fun.

 

[d0se1]

Everyone on grey uses more or less than they think they do. I chuckle every time some says i use 3.5mg. No two vials are the same, no matter the test results. Most on higher doses have exceeded the 15mg threshold. Me included.