FatPanda
GLP-1 Apprentice
I am on the first month of tirz, so 2.5 mgs, and only recently learned of reta. Would it make more sense to just do reta or to stack with tirz?
Should I stack tirz and reta, or just use reta?
- Thread starter FatPanda
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Violent Nomad
Recently Joined
Stacking the two wouldn’t make much sense, they hit overlapping receptors, so you’d double up on side effects without added benefit. Better to ride Tirz through dose escalation and see how your body responds before even thinking about switching or combining.
wildcat0367
Recently Joined
I would stick with the tirz. for now and see how you respond over time. You can add reta. or switch over to it later if you stall out.This is an exiting time and if you pay attention to the details your results will be amazing. Keep it simple and use 1 at a time until you know how each effects you. Keep protein high and get your resistance training dialed in to preserve lean mass. Good luck on your journey, keep posting as you get results.
miss-sanne
GLP-1 Enthusiast
Tirz is amazing, try it out at first.
I had to go down in tirz because of feeling depressed at 10 mg, but I would have stayed otherwise.
I had to go down in tirz because of feeling depressed at 10 mg, but I would have stayed otherwise.
nonyabizznez
GLP-1 Specialist
You're on an introductory dose of the most proven effective FDA approved drug for weightloss. If you paid Lily's price for Tirz you'd be taking this more seriously and not having FOMO.
Another vote for sticking with the Tirz.
Another vote for sticking with the Tirz.
peptideusername
Moderator
This is the best take, IMO.
keangkong
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If you want to lose more than 15% of your pre-tirzepatide weight, I could see why you might want to try to retatrutide instead. Much of the bad side effects of these medicines come from their GLP-1 action. Semaglutide has stronger GLP-1 effects than tirzepatide. Tirzepatide has stronger GLP-1 effects than retatrutide. Also, eating is way more enjoyable without having that feeling that your stomach is full. On reta, I actually desire to eat less even though I enjoy eating more than when on a high dose of tirz.
For cost reasons, it might make sense to combine tirz and reta since you already own the tirz (and tirz is cheaper).
I do think that there is some advantage in terms of safety and knowing what to do with tirzepatide because the stage 3 trials have been conducted, tirzepatide has been FDA approved, and it has already been informally tested in the real world by millions of folks.
For cost reasons, it might make sense to combine tirz and reta since you already own the tirz (and tirz is cheaper).
I do think that there is some advantage in terms of safety and knowing what to do with tirzepatide because the stage 3 trials have been conducted, tirzepatide has been FDA approved, and it has already been informally tested in the real world by millions of folks.
BooneDonk
GLP-1 Enthusiast
What @keangkong said, but I haven’t used TIRZ. I’ve watched the wife on Sema for close to two years now. Brother in law and his wife on Tirz for close to a year. I’ll take my Reta over the sides I’ve watched with the others. That said, the results of Sema and Tirz for my family are AMAZING! Don’t discount that at all. My vote overall is use the Tirz, you already paid for it. Switch or stack if you stall out or sides are 💩. Listen to your body.
I just added Reta because been stalled on Tirz last couple months which I've moved up to 12.5mg and was doing 10mg Tirz every 5 days. I figured I could try Reta and see if that worked. I meant to start with .25mg dose, but forgot my calculations and did .5mg Reta to start. Probably /hoping fine since way up on Tirz. I tried adding cjc295 w/o dac but noticed nothing, maybe even up an oz or two everytime I did a shot. Maybe I need more exercise or protein when taking that. Anyway hope the hunger suppression works with not much nausea. I rarely have constipation because drinks tons of water so we shall see. I'm not sure whether to alternate/stack Reta / Tirz or not. Seems most on this thread say no.
Rockybalboa
Recently Joined
Myself have been doing that for a month now.
3-4 mg of reta and 2-3 mg tirza.
Sunday Reta and wednesday tirz.
I find that mixing them works great and i actually think that Tirz so far is the best compund for me.
desinr-gal
GLP-1 Enthusiast
Not true, if you take less of each, and dont take on the same days. I am stacking these, as have many others quite successfully. The only side effect I have gotten is sleepiness in the afternoons. My food noise is absent, so is hunger. I eat to reach goals and mostly feel great. I am dosing under both protocals.
The emphasis of Reta on the other receptors, combined with Tirz emphasis on Glp1 means they fit together like a puzzle. So far it is working well for me.
keangkong
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The tirz won't hit your glucagon receptor.
Too bad Eli Lilly couldn’t figure this out when they formulated reta. They would have had a real blockbuster on their hands.
Sandman1972
GLP-1 Novice
If Tirz is working don’t jump just yet. Let it do its thing. Switch if you stall. Just an opinion.
From my understanding the initial dosing schedule being once weekly was to give the receptors a slight break for a couple days.
Seems like splitting between reta a tirz would be more beneficial than splitting tirz into a twice a week dose. While still giving the glucagon receptor a break.
Also seems to be more beneficial than splitting a reta dose because from my understanding tirz has better anti-inflammatory benefits and food noise control. Those things considered I can see the logic in it.
ZuZuPetals
GLP-1 Novice
I've been enjoying excellent results on Tirz alone. Started May 5, down 51.8 pounds as of today. Recommend sticking with Tirz alone to see how it goes
trinik28
Recently Joined
I started on Tirzepatide and lost 20 lbs in a month and heard about reta so I switched, I started at 2 for 2 weeks and I bumped it up to 3 last week ( so I had enough until my order came in) but I have only lost 1 lb. I hardly eat. Im definitely in a calorie deficit. My work keeps me on my feet and walking lots, and I've been doing weights in the morning before work. I havent been eating shitty. I was wondering if I should stack tirz and reta. Or just wait and ride out the reta and go up in the dose. Or switch back to tirz.
miss-sanne
GLP-1 Enthusiast
you should wait, give your brain time to adjust.
There is no point to switching or stacking, give the drug a chance and be patient.
Why did you switch when Tirz worked so well ? Tirz is an amazing drug.
good replies to your post, but i'll just reiterate, not much reason to stack any additional weight loss pep when you are so early in the tirz journey. just adding more cost, more jabs, more risk, more side effects. see how tirz goes for you first, seems like most people get great results for up to a year on tirz alone
trinik28
Recently Joined
Because I heard reta was better. One of my coworkers is on reta. And she lost petty good on it. The last time I pinned 3 mg of reta I had really bad gas and bloating. I just pinned 3 today so hoping it was the turkey dinner...lol
Rolltide61
GLP-1 Novice
I think there is a benefit to stacking the tirz and reta. Tirz is working for you which is good but reta performs nutrient partitioning which is something bodybuilders have dreamed about.
Google it. There are some that claimed that you could do it w/ diet but you can't. That is unless you ate the cleanest and well balanced diet on earth w/ animals that are pure and veggies that are pesticide free and grown in nutrient dense soil. Then there is the pollution in the air... you get my drift.
And never ever eat anything processed ever again.
Realistically, we have nothing but anecdotal reports on what happens with stacking. We don't know the long term impact and risks, if any.
Other glucagon agonist drugs (NN1177) have failed trials due to safety concerns - it's possible the ratio is important to keeping them safe.
I personally am not a fan of stacking multiple drugs in this category, but a lot of people do seem to be having short to medium term success doing so, and that might carry through to the long term. Might not.
Other glucagon agonist drugs (NN1177) have failed trials due to safety concerns - it's possible the ratio is important to keeping them safe.
I personally am not a fan of stacking multiple drugs in this category, but a lot of people do seem to be having short to medium term success doing so, and that might carry through to the long term. Might not.
Ribboncutter21
Recently Joined
Well this was an impactful thread. I am about to start my second dose 10.0 of tirz. It's been a bit of a surprising last 4 weeks for me. So, I was a sema non-responder. Food noise was much quieter, and I was not completely unhappy, but my insurance was pushing for results or cancel of coverage. I switched to to tirz and bam. Food noise was gone and so was my appetite--like I had to remind myself that food was necessary. BUT, these past few weeks I've noticed that tirz has not been as "powerful" in that area as my initial transition from sema to tirz. As mentioned in a previous introductory thread, I have found myself in the peptide world as I prep for insurance canceled coverage and/or just having more ownership over my access to GLP-1's. I have coverage with tirz until at least Feb 2026, so I was like ya know, let me dip my little toesies in. I JUST placed an order for reta after reading various reddit posts on stacking/split dosing with reta. Reading more on this forum has me me wondering if I made a mistake. Lol. Like I should have bought Cagri instead. I'm just a baby. 🫠
Well when I finally get to reta I hope it doesn't give me gas!!! I just came off a 4 year gas fest from eating cashews daily!! I didn't know that cashews were what was causing the gas!! I thought that it was happening because I was getting old LOL
keangkong
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Is there a reason that you're not waiting to see if a higher dose of tirz will work better?
Ribboncutter21
Recently Joined
Fair question. Honestly what I was reading, it sounded like that was the path I needed to go down. With so much info out there (and a lot of stacking being anecdotal) it was like taking a jump and then having second thoughts after I did. I realize at at 10mg on tirz I'm still titrating up. But I was feeling a bit let down at 7.5, so doc agreed it was time to move me up. I was nervous not feeling any difference on the first week at 10mg. With the idea that stacking reta would be no issue (then insert this thread), I thought I was making a choice that would support my current regiment, but a lot of what I am reading is that it could be counterproductive.
trinik28
Recently Joined
So every time I went to my mother-in-law’s place, we’d have sushi—and she always had a bowl of cashews out. Turns out, that combo is basically a biological weapon for me. Instant gas. Like, make-the-dog-leave-the-room level.
Trying to be polite, I’d sneak out onto her balcony for a smoke and to, uh… release some pressure. I thought I was being considerate.
What I didn’t realize is that her air conditioner intake was right there.
So I stroll back inside all relaxed, and everyone’s sniffing around, looking confused, trying to figure out what died. Meanwhile, I’m standing there pretending to be just as concerned—completely unaware I’d just fumigated the entire house through the AC.
Moral of the story: never mix sushi, cashews, and a well-placed air conditioner. 💀😂
Trying to be polite, I’d sneak out onto her balcony for a smoke and to, uh… release some pressure. I thought I was being considerate.
What I didn’t realize is that her air conditioner intake was right there.
So I stroll back inside all relaxed, and everyone’s sniffing around, looking confused, trying to figure out what died. Meanwhile, I’m standing there pretending to be just as concerned—completely unaware I’d just fumigated the entire house through the AC.
Moral of the story: never mix sushi, cashews, and a well-placed air conditioner. 💀😂
keangkong
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I don't worry about situations like that since I know that my farts smell great.
