FatPanda
GLP-1 Apprentice
I am on the first month of tirz, so 2.5 mgs, and only recently learned of reta. Would it make more sense to just do reta or to stack with tirz?
Should I stack tirz and reta, or just use reta?
- Thread starter FatPanda
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Violent Nomad
Recently Joined
Stacking the two wouldn’t make much sense, they hit overlapping receptors, so you’d double up on side effects without added benefit. Better to ride Tirz through dose escalation and see how your body responds before even thinking about switching or combining.
wildcat0367
Recently Joined
I would stick with the tirz. for now and see how you respond over time. You can add reta. or switch over to it later if you stall out.This is an exiting time and if you pay attention to the details your results will be amazing. Keep it simple and use 1 at a time until you know how each effects you. Keep protein high and get your resistance training dialed in to preserve lean mass. Good luck on your journey, keep posting as you get results.
miss-sanne
GLP-1 Novice
Tirz is amazing, try it out at first.
I had to go down in tirz because of feeling depressed at 10 mg, but I would have stayed otherwise.
I had to go down in tirz because of feeling depressed at 10 mg, but I would have stayed otherwise.
nonyabizznez
GLP-1 Specialist
You're on an introductory dose of the most proven effective FDA approved drug for weightloss. If you paid Lily's price for Tirz you'd be taking this more seriously and not having FOMO.
Another vote for sticking with the Tirz.
Another vote for sticking with the Tirz.
peptideusername
Moderator
This is the best take, IMO.
keangkong
GLP-1 Specialist
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If you want to lose more than 15% of your pre-tirzepatide weight, I could see why you might want to try to retatrutide instead. Much of the bad side effects of these medicines come from their GLP-1 action. Semaglutide has stronger GLP-1 effects than tirzepatide. Tirzepatide has stronger GLP-1 effects than retatrutide. Also, eating is way more enjoyable without having that feeling that your stomach is full. On reta, I actually desire to eat less even though I enjoy eating more than when on a high dose of tirz.
For cost reasons, it might make sense to combine tirz and reta since you already own the tirz (and tirz is cheaper).
I do think that there is some advantage in terms of safety and knowing what to do with tirzepatide because the stage 3 trials have been conducted, tirzepatide has been FDA approved, and it has already been informally tested in the real world by millions of folks.
For cost reasons, it might make sense to combine tirz and reta since you already own the tirz (and tirz is cheaper).
I do think that there is some advantage in terms of safety and knowing what to do with tirzepatide because the stage 3 trials have been conducted, tirzepatide has been FDA approved, and it has already been informally tested in the real world by millions of folks.
BooneDonk
GLP-1 Enthusiast
What @keangkong said, but I haven’t used TIRZ. I’ve watched the wife on Sema for close to two years now. Brother in law and his wife on Tirz for close to a year. I’ll take my Reta over the sides I’ve watched with the others. That said, the results of Sema and Tirz for my family are AMAZING! Don’t discount that at all. My vote overall is use the Tirz, you already paid for it. Switch or stack if you stall out or sides are 💩. Listen to your body.
I just added Reta because been stalled on Tirz last couple months which I've moved up to 12.5mg and was doing 10mg Tirz every 5 days. I figured I could try Reta and see if that worked. I meant to start with .25mg dose, but forgot my calculations and did .5mg Reta to start. Probably /hoping fine since way up on Tirz. I tried adding cjc295 w/o dac but noticed nothing, maybe even up an oz or two everytime I did a shot. Maybe I need more exercise or protein when taking that. Anyway hope the hunger suppression works with not much nausea. I rarely have constipation because drinks tons of water so we shall see. I'm not sure whether to alternate/stack Reta / Tirz or not. Seems most on this thread say no.
Rockybalboa
Recently Joined
Myself have been doing that for a month now.
3-4 mg of reta and 2-3 mg tirza.
Sunday Reta and wednesday tirz.
I find that mixing them works great and i actually think that Tirz so far is the best compund for me.
desinr-gal
GLP-1 Enthusiast
Not true, if you take less of each, and dont take on the same days. I am stacking these, as have many others quite successfully. The only side effect I have gotten is sleepiness in the afternoons. My food noise is absent, so is hunger. I eat to reach goals and mostly feel great. I am dosing under both protocals.
The emphasis of Reta on the other receptors, combined with Tirz emphasis on Glp1 means they fit together like a puzzle. So far it is working well for me.
keangkong
GLP-1 Specialist
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The tirz won't hit your glucagon receptor.
Too bad Eli Lilly couldn’t figure this out when they formulated reta. They would have had a real blockbuster on their hands.
Sandman1972
GLP-1 Novice
If Tirz is working don’t jump just yet. Let it do its thing. Switch if you stall. Just an opinion.
From my understanding the initial dosing schedule being once weekly was to give the receptors a slight break for a couple days.
Seems like splitting between reta a tirz would be more beneficial than splitting tirz into a twice a week dose. While still giving the glucagon receptor a break.
Also seems to be more beneficial than splitting a reta dose because from my understanding tirz has better anti-inflammatory benefits and food noise control. Those things considered I can see the logic in it.
