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Nexaph usually overfills 10%. Amo/Bff is generally very close to the exact mg - at least based on tons of testing I saw around STG. That extra kick you're noticing in Nexaph could just be that 10% (unless you already accounted for it, and reconstituted for the extra mg).

The wording style doesn't necessarily match his previous one, but who knows.

All the GLP1 meds increase heart rate, it affects the vagus system if I recall correctly. For some is very subtle, for others more noticeable. I'm part of the group that struggles with this, with +10 bpm increase of resting heart rate. Reta would probably be a no go for me.

10mg tirz every Wed, with 0.25mg of sema every Saturday. So far almost a month in with this stack, and it has definitely helped with better (true) hunger cues, fullness feeling after eating, etc. I was voracious with tirz alone before adding the stack and the sprinkle of sema a few days later...

Tirz (and all GLP-1s for that matter) increase RHR. This increase might just be caused by Tirz. I was looking at my historical RHR, and I do have +20 or 30 bpms over my original pre-GLP numbers. I did have to stop my betablocker because my blood pressure went down, so that could also explain it...

I guess the key it's what is your resting HR. Mine is 80-90 range. All glps increase hr but reta is the worst apparently. Tirz got my RHR to 110 today and I'm not having any fun. Can't even imagine what reta would do to me.

You make a great point. I did both: I increased tirz (8.5 to 10 - weekly dose) and also added sema 0.25 4 days later. Sema is very strong on the GLP-1 component - and anecdotally - better at hunger management food noise suppression. Before adding sema, my tirz wasn't enough to control the...

Shotsy. The Android version.

I almost exclusively use Amo/BFF and regular pens. As nonyabizznez said, it has been tested to death, and their results are almost always very good - but NOT really a lot of overfill or very mild, not like others that have consistently over 15-20%. I never had an ISR but others did mid last...

I did two changes in the last 15 days: Increased tirzepatide from 8.5 to 10 (Wednesday shot) Added 0.25 semaglutide on Saturday So far, 2 doses of increased tirz and today I did the 2nd sema. I had some queasiness after my first sema dose, not really nausea, and the fullness feeling and food...

"All relevant postal items containing goods that are sent through the international postal network that are valued at or under $800 and that would otherwise qualify for the de minimis exemption are subject to a duty rate of either 30% of their value or $25 per item (increasing to $50 per item...

Im interested in your tirz + sema stack! I'm about to do the same. Increasing to 10mg of tirz and adding 0.25mg of sema 4 days later. I was having great results with tirz but for the past few weeks Ive been ravenous, food noise, no satiety at all. I could increase tirz even more but want to...

Bienvenido/a! 👋 Mi familia es de Perelada (Girona) pero vivo en USA. 🙂

Yes, increased RHR in tirzepatide (and all GLP1s for that matter) is a known side effect. Here's a slide from the SURMOUNT-1 3 year extension study. it gets better over time (stabilizes / decreases). Reta appears to be worse, but I don't have any hard data to share.

28 weeks of tirzepatide 49 lb lost, 27% bw lost Avg 1% body weight loss per week Very sedentary, not counting calories anymore. 24 lb to goal weight

Telegram doesn't work with Google voice. I tried. Somehow the validation never comes or your account gets poofed. I use a Google voice number for everything and I ended up having to use a real number in TG.

They're sending it to all their past customers, if you did a past purchased or engaged through email, they are letting everyone know.

This question gets asked a lot in Reddit and I always respond the same thing, with science. You can absolutely change your eating habits and ensure that you exercise, be constantly at your TDEE equilibrium to not gain weight. But it's extremely hard, because it's not only a lifestyle / habit...

is this the "dedicated shipping line" that some vendors mention? :ROFLMAO:

The official dosage of sema goes to 2.4mg which is roughly that 5mg of Tirz. Tirz is more powerful. Novo posted a press release a few days ago about a study being done with high dose sema, but we don't know much more. That one goes to 7.2mg. there's no info on how to go from 2.4mg to 7.2 so you...

Table 1 in that article, shows 30-40% of all reta groups with hypertension. Not sure what you call heart issues particularly. Table 3 I ckudes adverse effects but doesn't call out increased heart rate, so it wasn't severe I guess. Arrhythmia is very low.

I'd assume the transdermal/micro-needle could be something like what the CGM looks like in the Libre glucose monitor, maybe? But instead of measuring the glucose in interstitial fluid, they do a a release system to slowly get a GLP-1 dosage throughout the life of the patch. I could see how this...

Some ideas: Some foods are very worse than others, so look how you can tweak your diet. digestive enzymes are good option to try sometimes gas also causes pressure and indigestion, and you get burps. try simethicone pills/chewable. not sure what anti-acids you've tried, just chewable calcium...

I'm sure you're all aware that there's a clinical trial for high doses. Here's the link in case you haven't seen it. Still recruiting, so a long way until we officially see results. https://clinicaltrials.gov/study/NCT06037252

Insane progress, congratulations! It's not just the weight, but all the health gains. Wishing you the best for the new goals. My progress is not as dramatic, just 145 days since starting, 20% weight loss, I'm halfway ish.. 39 lb down, another 35-40 to go. Very close to getting into normal BMI...

As of 12/23/24 FDA Approves First Generic of Once-Daily GLP-1 Injection to Lower Blood Sugar in Patients with Type 2 Diabetes Today, the U.S. Food and Drug Administration approved the first generic referencing Victoza (liraglutide injection) 18 milligram/3 milliliter, a glucagon-like peptide-1...

Do you have a link to that study? I want to read more on the combination of tirz + metformin.

FYI This is the cagri sema trial that compares the two different auto injectors. It's a tiny study, 18 people for a few weeks only, so I'm unsure how thorough the findings would be in relation to the ph and oligomer/fibrils concerns. https://clinicaltrials.gov/study/NCT06716307

In Reddit you have the link to Discord In Discord, you have the link to telegram. Unfortunately, we can't point from Reddit to Telegram so we have that extra (annoying) step. And yes, delulu is a mod/admin.

Hi there, fellow Iowan here (Ankeny)! Welcome. I can't help on GLOW, I'm just focusing on tirzepatide at the moment :)

Most people don't have issues making the vials last more than 4 weeks. If you really want to split, you should make the whole thing and filter and split the amount into 2 sterile vials.

Domestic, Skye, Tydes and Nexaph but some would argue not to that last one. Overseas, there's a lot of back/forth with Amopure re: stinging but I had a great experience. ASC and QSC appear to also be widely liked.

I don't think anyone can answer that for you. There are several popular vendors around, if you look at the reviews from users you'll see what their pros/cons are. Domestic vendors are generally more expensive, most sell by vial and appear to have better reputation, certainly the experience is...

You are going to be ok. The first time it's scary. I was on your shoes a few weeks ago, also with an amopure order and it turned out just fine.

This is why I have a ton of stock in my freezer. EL can sue right and left but with the years worth of stuff, I can sleep better.

I'm curious to know what causes a "super responder" to be so successful at lower doses like 2.5. I started losing 1.5-2lb right away, not sure if I can call myself a super responder or what. It's not necessarily the starting weight, since the highest the starting weight, the faster/bigger...

Dealing with the same here. 46F and perimenopause. I don't have hot flashes and I don't suspect a huge hormonal issue (yet). I blame it on tirzepatide as a side effect at this point. Some people will tell you your blood glucose is low and you are waking up due to a cortisol spike caused by...

I got an email today that they lowered their shipping to $45.

The libre 2 app truly sucks. When you get the csv with the data dump you can see better, but you need to make all the visuals yourself. BTW, this is what my week looks like. Metformin 500mg ER + tirz 2.5. a bit less than 1000 calories daily, no exercise. It's... A flatline :ROFLMAO:

Means research subject :)

This is super cool. It's exactly what I'm seeing in mine too. No more spikes or up/down swings. A few small "hills" for sure. I'm also eating way less and very low carb anyway, so that absolutely helps. But for data nerds (I'm one of those too!) it's cool to see how it looks 😆 BTW great thought...

I wear one, Freestyle Libre 2, which is not the best out there but good enough IMO. I think it really depends on what your diagnoses are, what other meds you take and your GLP-1 dose. If you are T1D or T2D and need insulin, a CGM is a no brainer. If you are taking a high dose (10mg +) or have...

Ohh I love those cases. Do you have a link to purchase?

OMG, this is me. I count the hours to injection day. I feel like a junkie. But this stuff works so well that I can't help it. The injection itself doesn't bother, but I'm sure I'm getting a high just by thinking about injection day.

1000 mg but I'm very successful at a low dose of 2.5 so it will take me several years to go through all of this. Most likely will go bad before I can use it :ROFLMAO:

No stinging with L20 that I bought on 10/3 and received 3 days later from the US warehouse. Used new BAC, reconstituted 2 days before using. Injected cold (not leaving filled syringe to warm up). Felt it a tiny bit more than my usual compound but no burning or stinging.

No stinging with L20 that I bought on 10/3 and received 3 days later from the US warehouse. Used new BAC, reconstituted 2 days before using. Injected cold (not leaving filled syringe to warm up). Felt it a tiny bit more than my usual compound but no burning or stinging.

I'm guessing because it's a steroid? Any OTC steroid cream would do the trick, probably?

Honestly, you should not give a f#$% a^% of what others think. I get it, it's tough. I get judgement from my family too. But, this is for your health and for you, so focus on that. Get to your goal weight - with some medical guidance if you can - without worrying about what others may say, if...