You injected one that gelled? Did it un-gel before you made it part of your body?
Amopure stinging (here we go again)
- Thread starter Fonkymonky
- Start date
Vacation4us
GLP-1 Member
Not the best resealing vial either. I did use an 18 g needle with my BAC but I lost an entire 15 mg dose to dripping out the vial while drawing up the 3 other doses out of my T 60. Hope that doesn’t happen when I use a 25 g to reconstitute in 2 weeks. That would be 10 weeks of lost doses if it keeps happening.
Of course haha - was updating a previous post. I reconstituted it a few days prior, and a small portion gelled up on the side and took a few extra minutes to fully dissolve. If you go a few pages back I included a pic.
I use whatever amount makes the math easy when drawing out.
I am currently dosing at 10mg, so my 30mg vial gets .90 ml of Bacc water so each draw is 30 units.
I have 60mg vials on order and will probably move up to 12mg dose when they arrive, so will add 1.25 ml bacc for a 25 unit draw.
Vacation4us
GLP-1 Member
I don’t know if they are “cheaping out” on the vials. Vials leaking is not an unusual situation even with hospital vials I have used.
Pr0digalSun
GLP-1 Novice
Hi I joined this forum bc I found this thread when I googled “amopure tirz burning” and tbh I skipped pages 4-14 of the thread.
I can absolutely confirm this has nothing to do with needles dulling on stoppers, bc I use 1cc luer lock syringes with a preattached 25g to draw, then switch to a 31ga, just out of habit bc I do testosterone and HCG subQ injections EOD
RS has been on injectables almost all of the last 20 years, and out of any injection that they have ever done, including deep IM with fat 20ga needles, and trimix injections into their d*ck, the amo tirz was the most painful injection of RS’s life. Like shockingly painful. Hot burning lava during injection then lingering burn for 30 minutes.
Changing from 1/2” to 3/16” needle length, and changing from abdomen to thigh does not change the amount of burn. This is L15 diluted with 1ml bac water.
The product, however, is very effective. The vendor offered to replace with a different batch and responded within minutes of my email.
I suspect it’s related to an excipient like sodium citrate or another added preservative (but I’m just guessing). I can update here if the replacement product hurts as bad.
The most comfortable way found to inject is using 1/2” needle into a pinch of folded skin injected relatively slowly.
I can absolutely confirm this has nothing to do with needles dulling on stoppers, bc I use 1cc luer lock syringes with a preattached 25g to draw, then switch to a 31ga, just out of habit bc I do testosterone and HCG subQ injections EOD
RS has been on injectables almost all of the last 20 years, and out of any injection that they have ever done, including deep IM with fat 20ga needles, and trimix injections into their d*ck, the amo tirz was the most painful injection of RS’s life. Like shockingly painful. Hot burning lava during injection then lingering burn for 30 minutes.
Changing from 1/2” to 3/16” needle length, and changing from abdomen to thigh does not change the amount of burn. This is L15 diluted with 1ml bac water.
The product, however, is very effective. The vendor offered to replace with a different batch and responded within minutes of my email.
I suspect it’s related to an excipient like sodium citrate or another added preservative (but I’m just guessing). I can update here if the replacement product hurts as bad.
The most comfortable way found to inject is using 1/2” needle into a pinch of folded skin injected relatively slowly.
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Pr0digalSun
GLP-1 Novice
Also I wanted to add that peptides are two amino acids linked in a chain, and I don’t know who started the myth, but shaking peptides does not break their molecular structure.
Ozempic and Mounjaro are predisolved in pens and there aren’t warnings on the boxes not to drop.
My degree is in chemistry and imho there are probably three things that could cause the burning
1. Incomplete synthesis leaving unreacted precursors
2. Excipients added as preservatives (like sodium citrate) or to ph balance (like HCl or NaOH)
3. Incomplete solubility caused by clumping
Since they pass their purity tests and since I know they are effective IMHO it’s bc the powder isn’t completely dissolving, and this would kind of track with why it seems I see small inconsistencies in the viscosity in the vial after mixing.
Ozempic and Mounjaro are predisolved in pens and there aren’t warnings on the boxes not to drop.
My degree is in chemistry and imho there are probably three things that could cause the burning
1. Incomplete synthesis leaving unreacted precursors
2. Excipients added as preservatives (like sodium citrate) or to ph balance (like HCl or NaOH)
3. Incomplete solubility caused by clumping
Since they pass their purity tests and since I know they are effective IMHO it’s bc the powder isn’t completely dissolving, and this would kind of track with why it seems I see small inconsistencies in the viscosity in the vial after mixing.
Pr0digalSun
GLP-1 Novice
Don’t get me wrong, im probably gonna grit my teeth and keep using unless it starts leaving lasting or visible reactions
Pr0digalSun
GLP-1 Novice
Also, I just read that someone tried using a syringe filter, and still it burns. That means it’s definately unreacted precursors or added excipients which makes me question the meaning of life and posted lab results hahah
Pr0digalSun
GLP-1 Novice
It arrived within 4 days or so.
I wouldn’t say that it’s been horrendous, tbh the results per $ are worth it for me
Edit: oops I misread and adjusted my response
nonyabizznez
GLP-1 Specialist
We were posting simultaneously... So your product came after they claimed to "resolve" the issue.
FWIW- and I've mentioned elsewhere my glucose readings were slightly better on Amopure than actual Mounjaro or Hallandale (89 vs 92). If the Amo wasn't effective they'd be much higher so we know the sh*t works. Maybe diluting it further and letting it rest longer before injection would help. I don't think shots 2 and 3 out of my vial were as bad, but I was expecting it. I'm going to use mine as well although I moved it to the back of rotation so it'll be the first to go in the circular file if not used in a few years.
Pr0digalSun
GLP-1 Novice
I wouldn’t have anti-tirzepetide antibodies on my first injection ever. And Ozempic doesn’t sting, so I don’t have cross-reactivity with other GLP’s
Even if I had antibodies, that wouldn’t make the injection itself sting, the immune response would cause redness and swelling to develop minutes to hours after the injection. I don’t have any redness or swelling, just acid-like burn, gone within an hour
Even if I had antibodies, that wouldn’t make the injection itself sting, the immune response would cause redness and swelling to develop minutes to hours after the injection. I don’t have any redness or swelling, just acid-like burn, gone within an hour
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I keep seeing posts saying pain is common from tirz injections but I had never heard of anything more than a mild annoyance until the amopure reports. So I setup a poll to get some numbers on the community’s experience and the pain level
Thread 'Tirz Burning Poll'
https://glp1forum.com/threads/tirz-burning-poll.1429/
Thread 'Tirz Burning Poll'
https://glp1forum.com/threads/tirz-burning-poll.1429/
Pr0digalSun
GLP-1 Novice
100% agree lol
The results per dollar is high enough I don’t mind getting stung by a hornet
(But if I get necrotizing fasciitis I take it back)
No stinging with L20 that I bought on 10/3 and received 3 days later from the US warehouse. Used new BAC, reconstituted 2 days before using. Injected cold (not leaving filled syringe to warm up). Felt it a tiny bit more than my usual compound but no burning or stinging.
noteablequotable
GLP-1 Specialist
Is anyone who has experienced severe stinging with Amo willing to send me a vial from the same batch? Having the reconstituted vial that caused the sting would be great as well. I have an idea that I want to test.
The thing is, there are so many other sources you can get it at for less than $1/mg with no stinging and no isr.
mostlydamp
GLP-1 Enthusiast
They just need to tell people that it stings because Amo's got electrolytes, that shit will fly off the shelves even faster
funkl
Recently Joined
RS took first shot of AMO L30 just a few minutes ago (05:30 PST 10.18.2024) and can report zero stinging or burning.
Process: Sprayed work area and supplies with 70% rubbing alcohol and wiped down. Reconstituted using Hospira (3.5ml) into tiny AMO L30 vial, gently rolled the vial for five minutes (timed), extracted, and dripped into sterile 7ml vial using 4mm syringe filter on a 25g luer lock needle.
L30 ordered 09.10.2024 and delivered 09.18.2024. Placed in vial storage case and stored in freezer for three weeks prior to reconstituting. Reconstituted vial sat in fridge in (separate) vial storage case for six days before using.
Just wanted to give my two cents here.
(PS, I won't be able to reply until later today)
Process: Sprayed work area and supplies with 70% rubbing alcohol and wiped down. Reconstituted using Hospira (3.5ml) into tiny AMO L30 vial, gently rolled the vial for five minutes (timed), extracted, and dripped into sterile 7ml vial using 4mm syringe filter on a 25g luer lock needle.
L30 ordered 09.10.2024 and delivered 09.18.2024. Placed in vial storage case and stored in freezer for three weeks prior to reconstituting. Reconstituted vial sat in fridge in (separate) vial storage case for six days before using.
Just wanted to give my two cents here.
(PS, I won't be able to reply until later today)
my RS had a post injection site reaction but no initial stinging so I'm not sure if you'd be interested still. What kind of research are you planning? 🤔
I was planning to toss the rest of this vial and do a new one with bacteriostatic sodium solution to see if it helps. If that doesn't work I'm gonna take the L and toss the kit. I'm worried about it causing an allergy later on down the line.
noteablequotable
GLP-1 Specialist
Well, the research itself is a secret, but I am hoping to find out why some people experience an initial sting that seems different from a normal ISR
YMMV, but here's my experience:
Purchased L30 on 10/4. Label Created 10/5. Delivered 10/11.
Reconstituted on 10/18 with 1.2ml Hospira Bac Water.
Felt like any other injection I've had that from grey, prescription or compounded. No stinging. No site reactions.
Purchased L30 on 10/4. Label Created 10/5. Delivered 10/11.
Reconstituted on 10/18 with 1.2ml Hospira Bac Water.
Felt like any other injection I've had that from grey, prescription or compounded. No stinging. No site reactions.
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Vacation4us
GLP-1 Member
Really sounds like very few people feel the sting.
noteablequotable
GLP-1 Specialist
I think given the fact that this thread was started on October 1st and already has 16 pages it's still more common than it should be. Not to mention the fact that people are also reporting this on other forums as well.
There are too many question marks to come to any conclusions which is why I think analyzing the reports (frequently and product) as well as any excipients that are being used would be best practice.
scarywood75
Scarlett Johansson
People have the tendancy to share negative reviews more than they would for positive experiences too.
Spot on. I purchased just to see what the craze was coming off the big sale/group buy test. Reports of the stinging really took off around then.
I didn't have a reaction and will get it tested.
I probably won't order from them again. Stinging or reports of stinging isn't something I am okay with knowing that I am was willing to pay above market price for easy payment, quality, and fast shipping. And I am saying this as someone who didn't experience the stinging.
LouiseBelcher
GLP-1 Novice
I have some Amo L10 that I purchased on Aug. 13, delivered Aug. 17. I haven't used it yet because I'm still making my way through the compounded stuff in my fridge, but I'm tempted to reconstitute and see if there's any stinging.
