I just recently switched from research sema to research Tirz. I didn’t really want to because $$ & sema was working. I wanted to try Tirz to see if I’d have zero side effects. The only side effect I had on sema (besides reflux and burps occasionally) was the increased heart rate. Which is worrisome since I already have a tendency for arrhythmias. The increased heart rate also meant I couldn’t work out while on it. My heart rate with very little effort would go very high (125-150 bpm). I’m normally someone who does cardio & weights several times a week, so not being able to even walk my neighborhood was frustrating. So, I switched to tirz 2 weeks ago. So far, heart rate is closer to normal! And I’m starting to work out again. Loving it!
eta: I had never gone above .375 every 5 or 6 days on sema, so I can’t imagine what the higher doses would’ve been like.