What Percentage of Body Weight Have You Lost?

13% down using semaglutide for a couple months followed by a break and then retatrutide for the last month and a half, but my goal was 27% loss in total on a very slow cut so it all feels within reason. So long as I see a positive trend, feel good, and hold onto my muscle mass, I will be quite happy -- so far, so good on all accounts.
 
JuneBug1956 said:
44%. From 250 to 140 lbs. Took 2 years.
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Wow! That's fantastic, congratulations. I'm wondering if you were able lose that all on tirzepatide? Or did you transition to a new medication or stack? I'm at one year and at 27% and need to lose another 12% of my starting weight and just hope that I can get there.
 
Grogu said:
Wow! That's fantastic, congratulations. I'm wondering if you were able lose that all on tirzepatide? Or did you transition to a new medication or stack? I'm at one year and at 27% and need to lose another 12% of my starting weight and just hope that I can get there.
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I started with Tirz for about 6-8 months. Lost @ 70 lbs my first year. I then added Sema for more appetite suppression. Eventually added Tesofensine. The last addition for the win was Cagri. I am still on all of the above but working my way down in my mg dose. I have stopped the Tesofensine. Presently on Tirz 10 mg every week, Sema 2 mg weekly ( 2 days after the Tirz and then Cagri 2 mg day 5 after the Tirz and done weekly. Love them all. Constipation is my only side but handle with miralax. Cagri and Teso warm me up. Tirz and Sema keep me cold. No fatigue, more energy.
 
JuneBug1956 said:
I started with Tirz for about 6-8 months. Lost @ 70 lbs my first year. I then added Sema for more appetite suppression. Eventually added Tesofensine. The last addition for the win was Cagri. I am still on all of the above but working my way down in my mg dose. I have stopped the Tesofensine. Presently on Tirz 10 mg every week, Sema 2 mg weekly ( 2 days after the Tirz and then Cagri 2 mg day 5 after the Tirz and done weekly. Love them all. Constipation is my only side but handle with miralax. Cagri and Teso warm me up. Tirz and Sema keep me cold. No fatigue, more energy.
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Thanks for the information! Hugely helpful. I just added sema on the third day after my current 15mg weekly dose of tirzepatide and I really like the feel. I'm going to try to ride this stack as long as possible and then add a third medication.
 
Mykrodot said:
I

I have no particular study, but have read that Cagrilintide works on the homeostatic and hedonic centers of the brain. So I'm assuming it clicks that sensor for me, I was a bit of a hedonist in my younger years! I had already started reducing my pain meds, but once starting Cagri it was easy. I haven't missed it a bit. Its a miracle really. Google “Cagrilintide hedonic”, you can probably find more there.
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I just started on Cagri and will stop taking tesa as I don't think it' worth taking till I drop some more weight. I take it in conjunction with Reta and while Reta helps with the food noise, my angry sugar cravings were in overdrive. Since I started on Cagri, no more sugar crazing's and can walk past the confectionary isle at the supermarket without even so much as a look at my favourite lollies.
 
I have gone from 295 to 210 this year. So I’ve lost approximately 30% of my total weight so far. My 2026 goal is 15% body fat. I’ve never been at or below 15%, even when I was in basic training at 18 years old, so I’m pretty excited to have a 6pack for the first time in my life at age 42!
 
31% in 18 months, just on Tirz for weight loss. It's been easy so far, minimal side effects, really dialed in my nutrition early on and lean on nutrition for results more than using the tirz. Got all the way up to 15mg, but recently took a 30 day break and restarted at 5mg. Seems to be working fine on the lower dose so will stick here for a while. Im happy to lose fat slowly as long as I am building muscle and strength at the same time.
 

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I used Sema to lose 35% since 2023. But stalled and gained a little bit back after having to go on high dose Prednisone in 2025 because of PMR. The good news is that is as good as weight loss surgery. The dose of Prednisone is now down to 15mg from 30mg and the GLP-1 seems to be working better again. I appear to have started losing weight again instead of slowly gaining. I started stacking Reta on to Sema last week and hope to lose 35-40 pounds from here over the rest of the year. If I'm not successful I may have to wait until I get the prednisone dose much lower. I'm cutting 1mg a week for now and should be down to 10 mg in five weeks.
 

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MsGizmo said:
I'm at 18% right around 44 weeks for me since I began my journey with GLP1s. Probably around 35 weeks with reta in the mix.

Started (05/04/2025) @ 334 and currently (02/17/2026) @ 273.
down 61 pounds and about 120 more to go.
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Congratulations! Awesome work.
 
30.4% down.Ten Months in. Tele-health Tirz. Hit goal. Now a new goal. Added Tesamorelin,5-Amino-1Mq.
Quit booze. Quit eating fried chicken; only eat at home. lift 3 days a week. My butt looks like it has a shark bite.
 

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So I think im over using nexpah. I really dont get suppression and it makes me very gassy and bloated. Any thoughts guys? I think i want a new vendor
 
britt1263 said:
So I think im over using nexpah. I really dont get suppression and it makes me very gassy and bloated. Any thoughts guys? I think i want a new vendor
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What are you researching and how much and how often and for how long have you been into your experiments???
 
skeptick said:
What are you researching and how much and how often and for how long have you been into your experiments???
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Research tirz! I mainly use my tele health and only use my nexpah when im low. Last week I gave my rat 5mg bc my rate has entered maintenance. My rate is down 100lbs with 98% due to the telahealth tirz. Last week my rat had a knot at injection site and no suppression also experienced alot of gas blotting and discomfort. This will be my rats 3rd attempt using nexpah. The knot is also still at injection site over a week later
 
britt1263 said:
Research tirz! I mainly use my tele health and only use my nexpah when im low. Last week I gave my rat 5mg bc my rate has entered maintenance. My rate is down 100lbs with 98% due to the telahealth tirz. Last week my rat had a knot at injection site and no suppression also experienced alot of gas blotting and discomfort. This will be my rats 3rd attempt using nexpah. The knot is also still at injection site over a week later
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Congrats to your rat for losing 100lbs... Research Rat GOD in my book. I've only just moved up to 10mg and having issues with extreme fatigue but then I've had chronic fatigue since well before startin Tirz path... Your symptoms new to me. Made me wonder about what you used for dilutant and how much you mixed with and how how much you hit your rat with??? Just the first thoughts to enter my pea brain...Hope yer able to sort it out... I'm much interested cause I got several years worth of Nexa squirreled away. (don't be tellin my S.O.) I'm still using Mounjaro and I've learnt myself how to split factory dosage into a new pen...
 
britt1263 said:
So I think im over using nexpah. I really dont get suppression and it makes me very gassy and bloated. Any thoughts guys? I think i want a new vendor
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I think...........I think that tirz is tirz is tirz no matter what vendor you get it from - it is all the same. Tele-health tirz is likely grey market relabelled. Same with Nexaph (and the rest of them).

I think...........I think that it may be possible that one of the two meds that you possess is over- or under- filled and also that there is some other process happening possibly.
 
GLP1Pharmacist said:
Keeping it off after stopping on need on going use?
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Since it has been at least 2 months since I stopped tesa, I thought I would provide an update.
Just had another dexa scan and VAT has decreased another 1.3 lbs and I have gained 6 lbs of lean muscle mass since last scan in October.

I have no way to prove this but I do believe that the tesa had a major impact on my VAT reduction - ALONG WITH - much healthier diet, super-focus on protein intake, consistent committed strength and cardio (not intense, just consistent).

I also know that - for me - it is not currently returning even without tesa and this is likely due to ongoing consistent dietary and exercise regimen.

I have not come off my 7.5mg/week tirz and 2 mg/week survo stack since November. Weight is within 1/2 lb today of what it was in November (187 lbs, goal weight down from 240 lbs in 5 months). BMI: 26.4 (and close enough since I go by Waist/Hip Ratio (0.98 currently) instead as it is more reflective of cardio/overall health than BMI). 23% decrease in body weight - almost all VAT. In the neighborhood of 75%. Waist was 46" inches July, 2025. Today, 3/10/26, it is 38.25".
 
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